Nanoscale topography reduces fibroblast growth, focal adhesion size and migration-related gene expression on platinum surfaces

[Display omitted] ► Cell responses to nanotextured platinum surfaces produced by glancing angle deposition (GLAD). ► Nanotopography modulates cell growth on platinum by affecting focal adhesions and cell spreading. ► Cell viability is not affected on nanotextured surfaces. ► Growth reduction is asso...

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Veröffentlicht in:	Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2011-07, Vol.85 (2), p.189-197
Hauptverfasser:	Pennisi, Cristian Pablo, Dolatshahi-Pirouz, Alireza, Foss, Morten, Chevallier, Jacques, Fink, Trine, Zachar, Vladimir, Besenbacher, Flemming, Yoshida, Ken
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Adhesion biocompatible materials Cell adhesion cell growth cell movement Cell Movement - drug effects Cell Movement - genetics Cell Proliferation - drug effects Cell Survival - drug effects cell viability Cells, Cultured Cellular colloids Cytoskeleton Cytoskeleton - drug effects Cytoskeleton - metabolism electrodes Fibroblasts Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - metabolism Focal adhesions Focal Adhesions - drug effects gene expression Gene Expression Regulation - drug effects genes Glancing angle deposition (GLAD) Humans microfilaments Microscopy, Atomic Force Nanocomposites Nanomaterials Nanostructure Nanostructures - chemistry Nanotechnology - methods Platinum Platinum - chemistry Platinum - pharmacology Surface nanotopography Surface Properties surface roughness Surgical implants tissue engineering topography
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