Biodegradable Sirolimus-loaded Poly(lactide) Nanoparticles as Drug Delivery System for the Prevention of In-Stent Restenosis in Coronary Stent Application

The administration of drugs using biodegradable polymer nanoparticles as carriers has generated immense interest due to their excellent biocompatibility and the prolonged drug release. The scope of this work was to determine the applicability of sirolimus-loaded biodegradable poly(D,L-lactide) (PDLL...

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Veröffentlicht in:	Journal of biomaterials applications 2011-05, Vol.25 (8), p.851-875
Hauptverfasser:	Luderer, Frank, Löbler, Marian, Rohm, Henning W., Gocke, Christian, Kunna, Katharina, Köck, Kathleen, Kroemer, Heyo K., Weitschies, Werner, Schmitz, Klaus-Peter, Sternberg, Katrin
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorbable Implants Biocompatibility Biodegradability Carriers Cell Line Cell Proliferation - drug effects Cell Survival - drug effects Coronary Restenosis - prevention & control Coronary Stenosis - etiology Coronary Stenosis - prevention & control Drug Carriers - chemistry Drug delivery systems Drug Delivery Systems - instrumentation Drugs Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelial Cells - ultrastructure Humans Implantation Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - ultrastructure Nanoparticles Nanoparticles - chemistry Particle Size Polyesters - chemistry Sirolimus - administration & dosage Stents - adverse effects Surgical implants
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