Biodegradable Sirolimus-loaded Poly(lactide) Nanoparticles as Drug Delivery System for the Prevention of In-Stent Restenosis in Coronary Stent Application
The administration of drugs using biodegradable polymer nanoparticles as carriers has generated immense interest due to their excellent biocompatibility and the prolonged drug release. The scope of this work was to determine the applicability of sirolimus-loaded biodegradable poly(D,L-lactide) (PDLL...
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| Veröffentlicht in: | Journal of biomaterials applications 2011-05, Vol.25 (8), p.851-875 |
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| container_title | Journal of biomaterials applications |
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| creator | Luderer, Frank Löbler, Marian Rohm, Henning W. Gocke, Christian Kunna, Katharina Köck, Kathleen Kroemer, Heyo K. Weitschies, Werner Schmitz, Klaus-Peter Sternberg, Katrin |
| description | The administration of drugs using biodegradable polymer nanoparticles as carriers has generated immense interest due to their excellent biocompatibility and the prolonged drug release. The scope of this work was to determine the applicability of sirolimus-loaded biodegradable poly(D,L-lactide) (PDLLA) nanoparticles as drug carriers to prevent restenotic processes after stent implantation. The average 250 nm sized 20%(w/w) sirolimus-loaded nanoparticles were extensively characterized with regard to in vitro degradation, biocompatibility and in vitro drug release. The particles show biphasic release kinetics consisting of a short burst release of 50%(w/w) sirolimus payload, followed by a longer, slower release phase, which are desirable for the application as a drug delivery carrier. All presented results exhibit the potential of sirolimus-loaded PDLLA nanoparticles as promising local and sustained drug delivery systems administered intraluminally to reduce in-stent restenosis after stent implantation. |
| doi_str_mv | 10.1177/0885328209360696 |
| format | Article |
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The scope of this work was to determine the applicability of sirolimus-loaded biodegradable poly(D,L-lactide) (PDLLA) nanoparticles as drug carriers to prevent restenotic processes after stent implantation. The average 250 nm sized 20%(w/w) sirolimus-loaded nanoparticles were extensively characterized with regard to in vitro degradation, biocompatibility and in vitro drug release. The particles show biphasic release kinetics consisting of a short burst release of 50%(w/w) sirolimus payload, followed by a longer, slower release phase, which are desirable for the application as a drug delivery carrier. All presented results exhibit the potential of sirolimus-loaded PDLLA nanoparticles as promising local and sustained drug delivery systems administered intraluminally to reduce in-stent restenosis after stent implantation.</description><identifier>ISSN: 0885-3282</identifier><identifier>EISSN: 1530-8022</identifier><identifier>DOI: 10.1177/0885328209360696</identifier><identifier>PMID: 20237179</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Absorbable Implants ; Biocompatibility ; Biodegradability ; Carriers ; Cell Line ; Cell Proliferation - drug effects ; Cell Survival - drug effects ; Coronary Restenosis - prevention & control ; Coronary Stenosis - etiology ; Coronary Stenosis - prevention & control ; Drug Carriers - chemistry ; Drug delivery systems ; Drug Delivery Systems - instrumentation ; Drugs ; Endothelial Cells - drug effects ; Endothelial Cells - metabolism ; Endothelial Cells - ultrastructure ; Humans ; Implantation ; Myocytes, Smooth Muscle - drug effects ; Myocytes, Smooth Muscle - metabolism ; Myocytes, Smooth Muscle - ultrastructure ; Nanoparticles ; Nanoparticles - chemistry ; Particle Size ; Polyesters - chemistry ; Sirolimus - administration & dosage ; Stents - adverse effects ; Surgical implants</subject><ispartof>Journal of biomaterials applications, 2011-05, Vol.25 (8), p.851-875</ispartof><rights>The Author(s), 2010.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c401t-a43ae573d6481d1694f2fdb5582bf94a781a2df1c6921a71b42b9d765a20b7203</citedby><cites>FETCH-LOGICAL-c401t-a43ae573d6481d1694f2fdb5582bf94a781a2df1c6921a71b42b9d765a20b7203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0885328209360696$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0885328209360696$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20237179$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luderer, Frank</creatorcontrib><creatorcontrib>Löbler, Marian</creatorcontrib><creatorcontrib>Rohm, Henning W.</creatorcontrib><creatorcontrib>Gocke, Christian</creatorcontrib><creatorcontrib>Kunna, Katharina</creatorcontrib><creatorcontrib>Köck, Kathleen</creatorcontrib><creatorcontrib>Kroemer, Heyo K.</creatorcontrib><creatorcontrib>Weitschies, Werner</creatorcontrib><creatorcontrib>Schmitz, Klaus-Peter</creatorcontrib><creatorcontrib>Sternberg, Katrin</creatorcontrib><title>Biodegradable Sirolimus-loaded Poly(lactide) Nanoparticles as Drug Delivery System for the Prevention of In-Stent Restenosis in Coronary Stent Application</title><title>Journal of biomaterials applications</title><addtitle>J Biomater Appl</addtitle><description>The administration of drugs using biodegradable polymer nanoparticles as carriers has generated immense interest due to their excellent biocompatibility and the prolonged drug release. The scope of this work was to determine the applicability of sirolimus-loaded biodegradable poly(D,L-lactide) (PDLLA) nanoparticles as drug carriers to prevent restenotic processes after stent implantation. The average 250 nm sized 20%(w/w) sirolimus-loaded nanoparticles were extensively characterized with regard to in vitro degradation, biocompatibility and in vitro drug release. The particles show biphasic release kinetics consisting of a short burst release of 50%(w/w) sirolimus payload, followed by a longer, slower release phase, which are desirable for the application as a drug delivery carrier. All presented results exhibit the potential of sirolimus-loaded PDLLA nanoparticles as promising local and sustained drug delivery systems administered intraluminally to reduce in-stent restenosis after stent implantation.</description><subject>Absorbable Implants</subject><subject>Biocompatibility</subject><subject>Biodegradability</subject><subject>Carriers</subject><subject>Cell Line</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Coronary Restenosis - prevention & control</subject><subject>Coronary Stenosis - etiology</subject><subject>Coronary Stenosis - prevention & control</subject><subject>Drug Carriers - chemistry</subject><subject>Drug delivery systems</subject><subject>Drug Delivery Systems - instrumentation</subject><subject>Drugs</subject><subject>Endothelial Cells - drug effects</subject><subject>Endothelial Cells - metabolism</subject><subject>Endothelial Cells - ultrastructure</subject><subject>Humans</subject><subject>Implantation</subject><subject>Myocytes, Smooth Muscle - drug effects</subject><subject>Myocytes, Smooth Muscle - metabolism</subject><subject>Myocytes, Smooth Muscle - ultrastructure</subject><subject>Nanoparticles</subject><subject>Nanoparticles - chemistry</subject><subject>Particle Size</subject><subject>Polyesters - chemistry</subject><subject>Sirolimus - administration & dosage</subject><subject>Stents - adverse effects</subject><subject>Surgical implants</subject><issn>0885-3282</issn><issn>1530-8022</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1DAUhS0EokNhzwp5R1kE_IofyzLlUamCioF15MQ3gysnDnZSaf4KvxaHKSyQAHlxZZ3vHF3dg9BTSl5SqtQronXNmWbEcEmkkffQhtacVJowdh9tVrla9RP0KOcbQkhthHyIThhhXFFlNuj7ax8d7JN1tg2Adz7F4IclVyFaBw5fx3A4C7abvYMX-IMd42TT7LsAGduML9KyxxcQ_C2kA94d8gwD7mPC81fA1wluYZx9HHHs8eVY7ebyxZ-gUGPMPmM_4m1McbSr-ad4Pk3Bd3Y1PUYPehsyPLmbp-jL2zeft--rq4_vLrfnV1UnCJ0rK7iFWnEnhaaOSiN61ru2rjVreyOs0tQy19NOGkatoq1grXFK1paRVjHCT9HzY-6U4relLNcMPncQgh0hLrnRSjJeHvs_KbUxQjFeyLN_klTqsp_kRhSUHNEuxZwT9M2U_FAu0lDSrC03f7ZcLM_u0pd2APfb8KvWAlRHINs9NDdxSWO54N8DfwCKaLBK</recordid><startdate>201105</startdate><enddate>201105</enddate><creator>Luderer, Frank</creator><creator>Löbler, Marian</creator><creator>Rohm, Henning W.</creator><creator>Gocke, Christian</creator><creator>Kunna, Katharina</creator><creator>Köck, Kathleen</creator><creator>Kroemer, Heyo K.</creator><creator>Weitschies, Werner</creator><creator>Schmitz, Klaus-Peter</creator><creator>Sternberg, Katrin</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><scope>7QO</scope><scope>P64</scope></search><sort><creationdate>201105</creationdate><title>Biodegradable Sirolimus-loaded Poly(lactide) Nanoparticles as Drug Delivery System for the Prevention of In-Stent Restenosis in Coronary Stent Application</title><author>Luderer, Frank ; Löbler, Marian ; Rohm, Henning W. ; Gocke, Christian ; Kunna, Katharina ; Köck, Kathleen ; Kroemer, Heyo K. ; Weitschies, Werner ; Schmitz, Klaus-Peter ; Sternberg, Katrin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c401t-a43ae573d6481d1694f2fdb5582bf94a781a2df1c6921a71b42b9d765a20b7203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Absorbable Implants</topic><topic>Biocompatibility</topic><topic>Biodegradability</topic><topic>Carriers</topic><topic>Cell Line</topic><topic>Cell Proliferation - drug effects</topic><topic>Cell Survival - drug effects</topic><topic>Coronary Restenosis - prevention & control</topic><topic>Coronary Stenosis - etiology</topic><topic>Coronary Stenosis - prevention & control</topic><topic>Drug Carriers - chemistry</topic><topic>Drug delivery systems</topic><topic>Drug Delivery Systems - instrumentation</topic><topic>Drugs</topic><topic>Endothelial Cells - drug effects</topic><topic>Endothelial Cells - metabolism</topic><topic>Endothelial Cells - ultrastructure</topic><topic>Humans</topic><topic>Implantation</topic><topic>Myocytes, Smooth Muscle - drug effects</topic><topic>Myocytes, Smooth Muscle - metabolism</topic><topic>Myocytes, Smooth Muscle - ultrastructure</topic><topic>Nanoparticles</topic><topic>Nanoparticles - chemistry</topic><topic>Particle Size</topic><topic>Polyesters - chemistry</topic><topic>Sirolimus - administration & dosage</topic><topic>Stents - adverse effects</topic><topic>Surgical implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luderer, Frank</creatorcontrib><creatorcontrib>Löbler, Marian</creatorcontrib><creatorcontrib>Rohm, Henning W.</creatorcontrib><creatorcontrib>Gocke, Christian</creatorcontrib><creatorcontrib>Kunna, Katharina</creatorcontrib><creatorcontrib>Köck, Kathleen</creatorcontrib><creatorcontrib>Kroemer, Heyo K.</creatorcontrib><creatorcontrib>Weitschies, Werner</creatorcontrib><creatorcontrib>Schmitz, Klaus-Peter</creatorcontrib><creatorcontrib>Sternberg, Katrin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of biomaterials applications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luderer, Frank</au><au>Löbler, Marian</au><au>Rohm, Henning W.</au><au>Gocke, Christian</au><au>Kunna, Katharina</au><au>Köck, Kathleen</au><au>Kroemer, Heyo K.</au><au>Weitschies, Werner</au><au>Schmitz, Klaus-Peter</au><au>Sternberg, Katrin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biodegradable Sirolimus-loaded Poly(lactide) Nanoparticles as Drug Delivery System for the Prevention of In-Stent Restenosis in Coronary Stent Application</atitle><jtitle>Journal of biomaterials applications</jtitle><addtitle>J Biomater Appl</addtitle><date>2011-05</date><risdate>2011</risdate><volume>25</volume><issue>8</issue><spage>851</spage><epage>875</epage><pages>851-875</pages><issn>0885-3282</issn><eissn>1530-8022</eissn><abstract>The administration of drugs using biodegradable polymer nanoparticles as carriers has generated immense interest due to their excellent biocompatibility and the prolonged drug release. The scope of this work was to determine the applicability of sirolimus-loaded biodegradable poly(D,L-lactide) (PDLLA) nanoparticles as drug carriers to prevent restenotic processes after stent implantation. The average 250 nm sized 20%(w/w) sirolimus-loaded nanoparticles were extensively characterized with regard to in vitro degradation, biocompatibility and in vitro drug release. The particles show biphasic release kinetics consisting of a short burst release of 50%(w/w) sirolimus payload, followed by a longer, slower release phase, which are desirable for the application as a drug delivery carrier. All presented results exhibit the potential of sirolimus-loaded PDLLA nanoparticles as promising local and sustained drug delivery systems administered intraluminally to reduce in-stent restenosis after stent implantation.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>20237179</pmid><doi>10.1177/0885328209360696</doi><tpages>25</tpages></addata></record> |
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| ispartof | Journal of biomaterials applications, 2011-05, Vol.25 (8), p.851-875 |
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| subjects | Absorbable Implants Biocompatibility Biodegradability Carriers Cell Line Cell Proliferation - drug effects Cell Survival - drug effects Coronary Restenosis - prevention & control Coronary Stenosis - etiology Coronary Stenosis - prevention & control Drug Carriers - chemistry Drug delivery systems Drug Delivery Systems - instrumentation Drugs Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelial Cells - ultrastructure Humans Implantation Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - ultrastructure Nanoparticles Nanoparticles - chemistry Particle Size Polyesters - chemistry Sirolimus - administration & dosage Stents - adverse effects Surgical implants |
| title | Biodegradable Sirolimus-loaded Poly(lactide) Nanoparticles as Drug Delivery System for the Prevention of In-Stent Restenosis in Coronary Stent Application |
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