A novel method to prepare methyl (4-trifluoromethoxy)phenylcarbamate and its analogues under mild conditions

Methyl (4-trifluoromethoxy)phenylcarbamate, the key intermediate for the synthesis of various excellent pesticides, was synthesized using two new, convenient methods with excellent yield and low cost compared to existing methods. We achieved a yield of over 95%, nearly quantitative in some cases. Our synthesis methods were also applied to other aniline derivatives to obtain the desired products with high yields. All reactions were conducted under mild conditions and very pure products were obtained. This method should be very useful in indoxacarb manufacturing, lowering the costs and avoiding excessive pollution.