Suppression by Fucoidan of Liver Fibrogenesis via the TGF-β/Smad Pathway in Protecting against Oxidative Stress

Fucoidan, a sulfated polysaccharide extracted from various types of brown seaweed, possesses a wide range of pharmacological properties. We investigated the protective effect of fucoidan on dimethylnitrosamine-induced liver fibrogenesis in rats and its mechanism. Liver fibrosis was induced by inject...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2011, Vol.75 (5), p.833-840
Hauptverfasser:	HONG, Sang-Won, JUNG, Kyung Hee, LEE, Hee-Seung, ZHENG, Hong-Mei, CHOI, Myung-Joo, LEE, Chongmu, HONG, Soon-Sun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anti-oxidant Antioxidants - metabolism Body Weight - drug effects Extracellular Matrix - drug effects Extracellular Matrix - metabolism fucoidan Gene Expression Regulation - drug effects Glutathione Peroxidase - blood Glutathione Peroxidase - metabolism inflammation Inflammation Mediators - metabolism Liver Cirrhosis - blood Liver Cirrhosis - drug therapy Liver Cirrhosis - metabolism Liver Cirrhosis - pathology liver fibrosis Male Malondialdehyde - blood Malondialdehyde - metabolism Organ Size - drug effects Oxidative Stress - drug effects Polysaccharides - pharmacology Polysaccharides - therapeutic use Rats Rats, Sprague-Dawley RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction - drug effects Smad Proteins - metabolism Superoxide Dismutase - blood Superoxide Dismutase - metabolism TGF-β/Smad Transforming Growth Factor beta - metabolism
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