Suppression by Fucoidan of Liver Fibrogenesis via the TGF-β/Smad Pathway in Protecting against Oxidative Stress
Fucoidan, a sulfated polysaccharide extracted from various types of brown seaweed, possesses a wide range of pharmacological properties. We investigated the protective effect of fucoidan on dimethylnitrosamine-induced liver fibrogenesis in rats and its mechanism. Liver fibrosis was induced by inject...
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| Veröffentlicht in: | Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2011, Vol.75 (5), p.833-840 |
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| creator | HONG, Sang-Won JUNG, Kyung Hee LEE, Hee-Seung ZHENG, Hong-Mei CHOI, Myung-Joo LEE, Chongmu HONG, Soon-Sun |
| description | Fucoidan, a sulfated polysaccharide extracted from various types of brown seaweed, possesses a wide range of pharmacological properties. We investigated the protective effect of fucoidan on dimethylnitrosamine-induced liver fibrogenesis in rats and its mechanism. Liver fibrosis was induced by injecting DMN (10 mg/kg, 3 times per week, I.P.) for 4 weeks, and fucoidan was simultaneously administered (100 mg/kg, 3 times per week, P.O.). The anti-oxidative and anti-inflammatory effects of fucoidan were observed by relative mediators. Fucoidan improved liver fibrosis by inhibiting the expression of transforming growth factor beta 1 (TGF-β
1
)/Smad3 and the tissue inhibitor of metalloproteinase 1 (TIMP-1), and increasing the expression of metalloproteinase-9 (MMP-9). Fucoidan also significantly decreased the accumulation of the extracellular matrix (ECM) and collagen. These results suggest that fucoidan had an anti-fibrotic effect, which was exerted by inhibiting the TGF-β/Smad pathway, as well as anti-oxidative and anti-inflammatory effects. |
| doi_str_mv | 10.1271/bbb.100599 |
| format | Article |
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1
)/Smad3 and the tissue inhibitor of metalloproteinase 1 (TIMP-1), and increasing the expression of metalloproteinase-9 (MMP-9). Fucoidan also significantly decreased the accumulation of the extracellular matrix (ECM) and collagen. These results suggest that fucoidan had an anti-fibrotic effect, which was exerted by inhibiting the TGF-β/Smad pathway, as well as anti-oxidative and anti-inflammatory effects.</description><identifier>ISSN: 0916-8451</identifier><identifier>ISSN: 1347-6947</identifier><identifier>EISSN: 1347-6947</identifier><identifier>DOI: 10.1271/bbb.100599</identifier><identifier>PMID: 21597183</identifier><language>eng</language><publisher>England: Japan Society for Bioscience, Biotechnology, and Agrochemistry</publisher><subject>Animals ; anti-oxidant ; Antioxidants - metabolism ; Body Weight - drug effects ; Extracellular Matrix - drug effects ; Extracellular Matrix - metabolism ; fucoidan ; Gene Expression Regulation - drug effects ; Glutathione Peroxidase - blood ; Glutathione Peroxidase - metabolism ; inflammation ; Inflammation Mediators - metabolism ; Liver Cirrhosis - blood ; Liver Cirrhosis - drug therapy ; Liver Cirrhosis - metabolism ; Liver Cirrhosis - pathology ; liver fibrosis ; Male ; Malondialdehyde - blood ; Malondialdehyde - metabolism ; Organ Size - drug effects ; Oxidative Stress - drug effects ; Polysaccharides - pharmacology ; Polysaccharides - therapeutic use ; Rats ; Rats, Sprague-Dawley ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Signal Transduction - drug effects ; Smad Proteins - metabolism ; Superoxide Dismutase - blood ; Superoxide Dismutase - metabolism ; TGF-β/Smad ; Transforming Growth Factor beta - metabolism</subject><ispartof>Bioscience, biotechnology, and biochemistry, 2011, Vol.75 (5), p.833-840</ispartof><rights>2011 by Japan Society for Bioscience, Biotechnology, and Agrochemistry 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-5b38c0c34d30a1ba180730f14e041289a9bb04fd94fe8dbd8ffddcf92f52b9dd3</citedby><cites>FETCH-LOGICAL-c454t-5b38c0c34d30a1ba180730f14e041289a9bb04fd94fe8dbd8ffddcf92f52b9dd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4023,27922,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21597183$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HONG, Sang-Won</creatorcontrib><creatorcontrib>JUNG, Kyung Hee</creatorcontrib><creatorcontrib>LEE, Hee-Seung</creatorcontrib><creatorcontrib>ZHENG, Hong-Mei</creatorcontrib><creatorcontrib>CHOI, Myung-Joo</creatorcontrib><creatorcontrib>LEE, Chongmu</creatorcontrib><creatorcontrib>HONG, Soon-Sun</creatorcontrib><title>Suppression by Fucoidan of Liver Fibrogenesis via the TGF-β/Smad Pathway in Protecting against Oxidative Stress</title><title>Bioscience, biotechnology, and biochemistry</title><addtitle>Biosci Biotechnol Biochem</addtitle><description>Fucoidan, a sulfated polysaccharide extracted from various types of brown seaweed, possesses a wide range of pharmacological properties. We investigated the protective effect of fucoidan on dimethylnitrosamine-induced liver fibrogenesis in rats and its mechanism. Liver fibrosis was induced by injecting DMN (10 mg/kg, 3 times per week, I.P.) for 4 weeks, and fucoidan was simultaneously administered (100 mg/kg, 3 times per week, P.O.). The anti-oxidative and anti-inflammatory effects of fucoidan were observed by relative mediators. Fucoidan improved liver fibrosis by inhibiting the expression of transforming growth factor beta 1 (TGF-β
1
)/Smad3 and the tissue inhibitor of metalloproteinase 1 (TIMP-1), and increasing the expression of metalloproteinase-9 (MMP-9). Fucoidan also significantly decreased the accumulation of the extracellular matrix (ECM) and collagen. These results suggest that fucoidan had an anti-fibrotic effect, which was exerted by inhibiting the TGF-β/Smad pathway, as well as anti-oxidative and anti-inflammatory effects.</description><subject>Animals</subject><subject>anti-oxidant</subject><subject>Antioxidants - metabolism</subject><subject>Body Weight - drug effects</subject><subject>Extracellular Matrix - drug effects</subject><subject>Extracellular Matrix - metabolism</subject><subject>fucoidan</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Glutathione Peroxidase - blood</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>inflammation</subject><subject>Inflammation Mediators - metabolism</subject><subject>Liver Cirrhosis - blood</subject><subject>Liver Cirrhosis - drug therapy</subject><subject>Liver Cirrhosis - metabolism</subject><subject>Liver Cirrhosis - pathology</subject><subject>liver fibrosis</subject><subject>Male</subject><subject>Malondialdehyde - blood</subject><subject>Malondialdehyde - metabolism</subject><subject>Organ Size - drug effects</subject><subject>Oxidative Stress - drug effects</subject><subject>Polysaccharides - pharmacology</subject><subject>Polysaccharides - therapeutic use</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Signal Transduction - drug effects</subject><subject>Smad Proteins - metabolism</subject><subject>Superoxide Dismutase - blood</subject><subject>Superoxide Dismutase - metabolism</subject><subject>TGF-β/Smad</subject><subject>Transforming Growth Factor beta - metabolism</subject><issn>0916-8451</issn><issn>1347-6947</issn><issn>1347-6947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkd1KIzEUgIO4aHW98QEkd8LC2GQm00wuRawKBYV2r0N-a2QmGZNMta-1D-IzOdK6Vwt7deDw8R04HwDnGF3hkuKplPIKI1QzdgAmuCK0mDFCD8EEMTwrGlLjY3CS0gtC46LGR-C4xDWjuKkmoF8OfR9NSi54KLdwPqjgtPAwWLhwGxPh3MkY1sab5BLcOAHzs4Gru3nx8We67ISGTyI_v4ktdB4-xZCNys6voVgL51OGj--jLo8muMxfd36CH1a0yZzt5yn4Pb9d3dwXi8e7h5vrRaFITXJRy6pRSFVEV0hgKXCDaIUsJgYRXDZMMCkRsZoRaxotdWOt1sqy0talZFpXp-By5-1jeB1MyrxzSZm2Fd6EIfGGzsqSUVr-n5wxyvbkrx2pYkgpGsv76DoRtxwj_pWCjyn4LsUIX-y1g-yM_ot-_34E6h3gvA2xE28htppnsW1DtFF45RKv_iH-BAEumFA</recordid><startdate>2011</startdate><enddate>2011</enddate><creator>HONG, Sang-Won</creator><creator>JUNG, Kyung Hee</creator><creator>LEE, Hee-Seung</creator><creator>ZHENG, Hong-Mei</creator><creator>CHOI, Myung-Joo</creator><creator>LEE, Chongmu</creator><creator>HONG, Soon-Sun</creator><general>Japan Society for Bioscience, Biotechnology, and Agrochemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>2011</creationdate><title>Suppression by Fucoidan of Liver Fibrogenesis via the TGF-β/Smad Pathway in Protecting against Oxidative Stress</title><author>HONG, Sang-Won ; JUNG, Kyung Hee ; LEE, Hee-Seung ; ZHENG, Hong-Mei ; CHOI, Myung-Joo ; LEE, Chongmu ; HONG, Soon-Sun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-5b38c0c34d30a1ba180730f14e041289a9bb04fd94fe8dbd8ffddcf92f52b9dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>anti-oxidant</topic><topic>Antioxidants - metabolism</topic><topic>Body Weight - drug effects</topic><topic>Extracellular Matrix - drug effects</topic><topic>Extracellular Matrix - metabolism</topic><topic>fucoidan</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Glutathione Peroxidase - blood</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>inflammation</topic><topic>Inflammation Mediators - metabolism</topic><topic>Liver Cirrhosis - blood</topic><topic>Liver Cirrhosis - drug therapy</topic><topic>Liver Cirrhosis - metabolism</topic><topic>Liver Cirrhosis - pathology</topic><topic>liver fibrosis</topic><topic>Male</topic><topic>Malondialdehyde - blood</topic><topic>Malondialdehyde - metabolism</topic><topic>Organ Size - drug effects</topic><topic>Oxidative Stress - drug effects</topic><topic>Polysaccharides - pharmacology</topic><topic>Polysaccharides - therapeutic use</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Signal Transduction - drug effects</topic><topic>Smad Proteins - metabolism</topic><topic>Superoxide Dismutase - blood</topic><topic>Superoxide Dismutase - metabolism</topic><topic>TGF-β/Smad</topic><topic>Transforming Growth Factor beta - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HONG, Sang-Won</creatorcontrib><creatorcontrib>JUNG, Kyung Hee</creatorcontrib><creatorcontrib>LEE, Hee-Seung</creatorcontrib><creatorcontrib>ZHENG, Hong-Mei</creatorcontrib><creatorcontrib>CHOI, Myung-Joo</creatorcontrib><creatorcontrib>LEE, Chongmu</creatorcontrib><creatorcontrib>HONG, Soon-Sun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Bioscience, biotechnology, and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HONG, Sang-Won</au><au>JUNG, Kyung Hee</au><au>LEE, Hee-Seung</au><au>ZHENG, Hong-Mei</au><au>CHOI, Myung-Joo</au><au>LEE, Chongmu</au><au>HONG, Soon-Sun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Suppression by Fucoidan of Liver Fibrogenesis via the TGF-β/Smad Pathway in Protecting against Oxidative Stress</atitle><jtitle>Bioscience, biotechnology, and biochemistry</jtitle><addtitle>Biosci Biotechnol Biochem</addtitle><date>2011</date><risdate>2011</risdate><volume>75</volume><issue>5</issue><spage>833</spage><epage>840</epage><pages>833-840</pages><issn>0916-8451</issn><issn>1347-6947</issn><eissn>1347-6947</eissn><abstract>Fucoidan, a sulfated polysaccharide extracted from various types of brown seaweed, possesses a wide range of pharmacological properties. We investigated the protective effect of fucoidan on dimethylnitrosamine-induced liver fibrogenesis in rats and its mechanism. Liver fibrosis was induced by injecting DMN (10 mg/kg, 3 times per week, I.P.) for 4 weeks, and fucoidan was simultaneously administered (100 mg/kg, 3 times per week, P.O.). The anti-oxidative and anti-inflammatory effects of fucoidan were observed by relative mediators. Fucoidan improved liver fibrosis by inhibiting the expression of transforming growth factor beta 1 (TGF-β
1
)/Smad3 and the tissue inhibitor of metalloproteinase 1 (TIMP-1), and increasing the expression of metalloproteinase-9 (MMP-9). Fucoidan also significantly decreased the accumulation of the extracellular matrix (ECM) and collagen. These results suggest that fucoidan had an anti-fibrotic effect, which was exerted by inhibiting the TGF-β/Smad pathway, as well as anti-oxidative and anti-inflammatory effects.</abstract><cop>England</cop><pub>Japan Society for Bioscience, Biotechnology, and Agrochemistry</pub><pmid>21597183</pmid><doi>10.1271/bbb.100599</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0916-8451 |
| ispartof | Bioscience, biotechnology, and biochemistry, 2011, Vol.75 (5), p.833-840 |
| issn | 0916-8451 1347-6947 1347-6947 |
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| source | J-STAGE Free; MEDLINE; Oxford University Press Journals All Titles (1996-Current); Freely Accessible Japanese Titles; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Animals anti-oxidant Antioxidants - metabolism Body Weight - drug effects Extracellular Matrix - drug effects Extracellular Matrix - metabolism fucoidan Gene Expression Regulation - drug effects Glutathione Peroxidase - blood Glutathione Peroxidase - metabolism inflammation Inflammation Mediators - metabolism Liver Cirrhosis - blood Liver Cirrhosis - drug therapy Liver Cirrhosis - metabolism Liver Cirrhosis - pathology liver fibrosis Male Malondialdehyde - blood Malondialdehyde - metabolism Organ Size - drug effects Oxidative Stress - drug effects Polysaccharides - pharmacology Polysaccharides - therapeutic use Rats Rats, Sprague-Dawley RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction - drug effects Smad Proteins - metabolism Superoxide Dismutase - blood Superoxide Dismutase - metabolism TGF-β/Smad Transforming Growth Factor beta - metabolism |
| title | Suppression by Fucoidan of Liver Fibrogenesis via the TGF-β/Smad Pathway in Protecting against Oxidative Stress |
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