HIV-1 activates proinflammatory and interferon-inducible genes in human brain microvascular endothelial cells: putative mechanisms of blood-brain barrier dysfunction

The mechanisms underlying blood—brain barrier (BBB) dysfunction seen in human immunodeficiency virus 1 (HIV-1) infection are poorly understood; however, they are believed to be caused by interactions of human brain microvascular endothelial cells (HBMEC) with virus-infected macrophages. Using a tran...

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Veröffentlicht in:	Journal of cerebral blood flow and metabolism 2008-04, Vol.28 (4), p.697-711
Hauptverfasser:	Chaudhuri, Anathbandhu, Duan, Fenghai, Morsey, Brenda, Persidsky, Yuri, Kanmogne, Georgette D
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blood-brain barrier Blood-Brain Barrier - physiology Blood-Brain Barrier - virology Blotting, Western Brain Brain - blood supply Brain - metabolism Cell Movement - physiology Cerebral blood flow Chemokines Coculture Techniques DNA probes Endothelial cells Endothelial Cells - physiology Endothelial Cells - virology Gene Expression Gene Expression Profiling Gene Expression Regulation, Viral genomics HIV Infections - physiopathology HIV-1 - physiology Human immunodeficiency virus 1 Human viral diseases Humans Infection Infectious diseases Inflammation Inflammation - genetics Inflammation - virology intercellular adhesion molecule 1 Interferon Interferons - physiology Internet Macrophages Macrophages - virology Medical sciences Metabolism Microvasculature Monocytes Neurology Oligonucleotide Array Sequence Analysis Reverse Transcriptase Polymerase Chain Reaction Signal transduction Transcription factors Tumor necrosis factor- alpha Vascular diseases and vascular malformations of the nervous system Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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