Retinal Degeneration Induced in Adult Mice by a Single Intraperitoneal Injection of N-Ethyl-N-Nitrosourea

Seven-week-old female BALB/c mice received a single intraperitoneal injection of N-ethyl-N-nitrosourea (ENU) (50, 100, 200, 400, or 600 mg/kg), and retinal damage was evaluated after 7 days. Sequential morphological features of the retina and retinal apoptosis, as determined by the TUNEL assay, were...

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Veröffentlicht in:	Toxicologic pathology 2011-06, Vol.39 (4), p.606-613
Hauptverfasser:	Yoshizawa, Katsuhiko, Kuro-Kuwata, Maki, Sasaki, Tomo, Lai, Yen-Chang Clark, Kanematsu, Sayaka, Miki, Hisanori, Kimura-Kawanaka, Ayako, Uehara, Norihisa, Yuri, Takashi, Tsubura, Airo
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Animals Apoptosis Apoptosis - drug effects Biological and medical sciences Dose-Response Relationship, Drug Ethyl nitrosourea Ethylnitrosourea - toxicity Female In Situ Nick-End Labeling - methods Injections, Intraperitoneal Medical sciences Mice Mice, Inbred BALB C Ophthalmology Photoreceptor Cells, Vertebrate - drug effects Photoreceptor Cells, Vertebrate - pathology Photoreceptors Retina Retina - drug effects retinal degeneration Retinal Degeneration - chemically induced Retinal Degeneration - pathology Retinopathies Toxicology
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