Deficiency of gelatinase B/MMP-9 aggravates lpr -induced lymphoproliferation and lupus-like systemic autoimmune disease

Abstract Gelatinase B/matrix metalloproteinase-9 (MMP-9) is a key enzyme involved in inflammatory, hematological, vascular and neoplastic diseases. In previous studies, we explored the intracellular substrate set or ‘degradome’ of MMP-9 and found many systemic autoantigens as novel intracellular gel...

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