Nucleic acid-stimulated antigen-presenting cells trigger T cells to induce disease in a rat transfer model of inflammatory arthritis

Abstract Autoimmune responses to heterogeneous nuclear ribonucleproteins (hnRNP) occur in many systemic autoimmune diseases, particularly in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus. In RA, humoral and/or cellular autoimmunity to hnRNP-A2/B1 is the most prominent anti...

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Veröffentlicht in:	Journal of autoimmunity 2011-05, Vol.36 (3), p.288-300
Hauptverfasser:	Hoffmann, Markus H, Skriner, Karl, Herman, Sonja, Baumann, Christoph, Steiner, Carl-Walter, Ospelt, Caroline, Meyer, Brigitte, Gleiss, Andreas, Pfatschbacher, Jürgen, Niederreiter, Birgit, Tuncel, Jonatan, Zanoni, Gerald, Steiner, Guenter
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antigen-Presenting Cells - immunology Arthritis Arthritis, Rheumatoid - etiology Autoantigen Damage-associated molecular pattern Heterogeneous-Nuclear Ribonucleoprotein Group A-B - immunology Humans Innate immunity Rats T-Lymphocytes - immunology Terpenes - toxicity Toll-Like Receptor 7 - physiology Toll-Like Receptor 9 - physiology Toll-like receptors
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