Quercetin reduces the elevated matrix metalloproteinases-9 level and improves functional outcome after cerebral focal ischemia in rats

Background Blood–brain barrier (BBB) disruption mediated by matrix metalloproteinase (MMPs) activation is a critical event during cerebral ischemia. The inhibition of MMP might be a potential approach to protect against secondary injury. The present study was designed to determine the effects of que...

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Veröffentlicht in:	Acta neurochirurgica 2011-06, Vol.153 (6), p.1321-1329
Hauptverfasser:	Lee, Jung-Kil, Kwak, Hyung-Jun, Piao, Min-Sheng, Jang, Jae-Won, Kim, Soo-Han, Kim, Hyung-Seok
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood-Brain Barrier - drug effects Brain Edema - pathology Brain Edema - physiopathology Cerebral Infarction - pathology Cerebral Infarction - physiopathology Experimental Research Immunoenzyme Techniques Interventional Radiology Male Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase Inhibitors Medicine Medicine & Public Health Minimally Invasive Surgery Neurology Neurons - drug effects Neurons - pathology Neuroradiology Neurosurgery Quercetin - pharmacology Rats Rats, Sprague-Dawley Rotarod Performance Test Surgical Orthopedics Up-Regulation - drug effects
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