Populationwide Investigation of Two Indel Polymorphisms at the Prion Protein Gene in Polish Holstein–Friesian Cattle
The allele, genotype, and haplotype frequencies among 837 Polish Holstein–Friesian cattle were determined at two regulatory indel polymorphisms of the PRNP gene. Allele frequencies at the 23 bp indel promoter polymorphism were 0.622 (del) and 0.378 (ins), with 0.613 and 0.387 in sires and 0.633 and...
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| Veröffentlicht in: | Biochemical genetics 2011-06, Vol.49 (5-6), p.303-312 |
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| creator | Czarnik, Urszula Strychalski, Janusz Zabolewicz, Tadeusz Pareek, Chandra S. |
| description | The allele, genotype, and haplotype frequencies among 837 Polish Holstein–Friesian cattle were determined at two regulatory indel polymorphisms of the
PRNP
gene. Allele frequencies at the 23 bp indel promoter polymorphism were 0.622 (del) and 0.378 (ins), with 0.613 and 0.387 in sires and 0.633 and 0.366 in dams. Allele frequencies at the 12 bp indel intron polymorphism were 0.527 (del) and 0.473 (ins), with 0.529 and 0.471 in sires and 0.543 and 0.456 in dams. Four haplotypes were identified in this population (23–12del, 23–12ins, 23del–12ins, and 23ins–12del). Haplotype 23–12del occurred most frequently in both sire and dam groups. Comparative analysis of Polish Holstein–Friesian and German Holstein populations revealed a similar genetic structure for the 23 bp indel polymorphism and a significantly different one for the 12 bp indel polymorphism. In allele and haplotype analysis, significant differences were observed between the Polish Holstein–Friesian population and a BSE-free German Holstein population. |
| doi_str_mv | 10.1007/s10528-010-9408-2 |
| format | Article |
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PRNP
gene. Allele frequencies at the 23 bp indel promoter polymorphism were 0.622 (del) and 0.378 (ins), with 0.613 and 0.387 in sires and 0.633 and 0.366 in dams. Allele frequencies at the 12 bp indel intron polymorphism were 0.527 (del) and 0.473 (ins), with 0.529 and 0.471 in sires and 0.543 and 0.456 in dams. Four haplotypes were identified in this population (23–12del, 23–12ins, 23del–12ins, and 23ins–12del). Haplotype 23–12del occurred most frequently in both sire and dam groups. Comparative analysis of Polish Holstein–Friesian and German Holstein populations revealed a similar genetic structure for the 23 bp indel polymorphism and a significantly different one for the 12 bp indel polymorphism. In allele and haplotype analysis, significant differences were observed between the Polish Holstein–Friesian population and a BSE-free German Holstein population.</description><identifier>ISSN: 0006-2928</identifier><identifier>EISSN: 1573-4927</identifier><identifier>DOI: 10.1007/s10528-010-9408-2</identifier><identifier>PMID: 21221760</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Animals ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Cattle ; Cattle - genetics ; Encephalopathy, Bovine Spongiform - genetics ; Female ; Gene Frequency ; Gene polymorphism ; Genetic structure ; Genetic Variation ; Haplotypes ; Human Genetics ; INDEL Mutation ; Introns ; Male ; Medical Microbiology ; Poland ; Polymorphism, Genetic ; Population genetics ; Prion protein ; Prions - genetics ; Promoter Regions, Genetic ; Sequence Analysis, DNA ; Zoology</subject><ispartof>Biochemical genetics, 2011-06, Vol.49 (5-6), p.303-312</ispartof><rights>Springer Science+Business Media, LLC 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-9a83bc8df08fba1083b366958a73653e5033171bbf0b5442fa257ad04d5a20fa3</citedby><cites>FETCH-LOGICAL-c402t-9a83bc8df08fba1083b366958a73653e5033171bbf0b5442fa257ad04d5a20fa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10528-010-9408-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10528-010-9408-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27907,27908,41471,42540,51302</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21221760$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Czarnik, Urszula</creatorcontrib><creatorcontrib>Strychalski, Janusz</creatorcontrib><creatorcontrib>Zabolewicz, Tadeusz</creatorcontrib><creatorcontrib>Pareek, Chandra S.</creatorcontrib><title>Populationwide Investigation of Two Indel Polymorphisms at the Prion Protein Gene in Polish Holstein–Friesian Cattle</title><title>Biochemical genetics</title><addtitle>Biochem Genet</addtitle><addtitle>Biochem Genet</addtitle><description>The allele, genotype, and haplotype frequencies among 837 Polish Holstein–Friesian cattle were determined at two regulatory indel polymorphisms of the
PRNP
gene. Allele frequencies at the 23 bp indel promoter polymorphism were 0.622 (del) and 0.378 (ins), with 0.613 and 0.387 in sires and 0.633 and 0.366 in dams. Allele frequencies at the 12 bp indel intron polymorphism were 0.527 (del) and 0.473 (ins), with 0.529 and 0.471 in sires and 0.543 and 0.456 in dams. Four haplotypes were identified in this population (23–12del, 23–12ins, 23del–12ins, and 23ins–12del). Haplotype 23–12del occurred most frequently in both sire and dam groups. Comparative analysis of Polish Holstein–Friesian and German Holstein populations revealed a similar genetic structure for the 23 bp indel polymorphism and a significantly different one for the 12 bp indel polymorphism. In allele and haplotype analysis, significant differences were observed between the Polish Holstein–Friesian population and a BSE-free German Holstein population.</description><subject>Animals</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cattle</subject><subject>Cattle - genetics</subject><subject>Encephalopathy, Bovine Spongiform - genetics</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Gene polymorphism</subject><subject>Genetic structure</subject><subject>Genetic Variation</subject><subject>Haplotypes</subject><subject>Human Genetics</subject><subject>INDEL Mutation</subject><subject>Introns</subject><subject>Male</subject><subject>Medical Microbiology</subject><subject>Poland</subject><subject>Polymorphism, Genetic</subject><subject>Population genetics</subject><subject>Prion protein</subject><subject>Prions - genetics</subject><subject>Promoter Regions, Genetic</subject><subject>Sequence Analysis, DNA</subject><subject>Zoology</subject><issn>0006-2928</issn><issn>1573-4927</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkc9O3DAQxi1UBAvtA_RSWb30FBiPY8c5Viv-SSuxBzhbzsZhjZJ4aycgbn2HvmGfBIddQKpUcRrNN7_5RqOPkK8MThhAcRoZCFQZMMjKHFSGe2TGRMGzvMTiE5kBgMywRHVIjmK8T20JeX5ADpEhskLCjDws_WZszeB8_-hqS6_6BxsHd_eiUN_Qm0efxNq2dOnbp86HzdrFLlIz0GFt6TJM3DL4wbqeXtje0lQT6uKaXvo2Tvrf33_Og7PRmZ7OzTC09jPZb0wb7ZddPSa352c388tscX1xNf-5yFY54JCVRvFqpeoGVFMZBqnjUpZCmYJLwa0AzlnBqqqBSuQ5NgZFYWrIa2EQGsOPyY-t7yb4X2P6THcurmzbmt76MWpVSEQJUn1MynSQI8hEfv-HvPdj6NMbk10pSo4sQWwLrYKPMdhGb4LrTHjSDPQUnt6Gp1N4egpPY9r5tjMeq87WbxuvaSUAt0BMo_7OhvfL_3d9BtiUpYM</recordid><startdate>20110601</startdate><enddate>20110601</enddate><creator>Czarnik, Urszula</creator><creator>Strychalski, Janusz</creator><creator>Zabolewicz, Tadeusz</creator><creator>Pareek, Chandra S.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7SS</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>20110601</creationdate><title>Populationwide Investigation of Two Indel Polymorphisms at the Prion Protein Gene in Polish Holstein–Friesian Cattle</title><author>Czarnik, Urszula ; Strychalski, Janusz ; Zabolewicz, Tadeusz ; Pareek, Chandra S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-9a83bc8df08fba1083b366958a73653e5033171bbf0b5442fa257ad04d5a20fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cattle</topic><topic>Cattle - genetics</topic><topic>Encephalopathy, Bovine Spongiform - genetics</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Gene polymorphism</topic><topic>Genetic structure</topic><topic>Genetic Variation</topic><topic>Haplotypes</topic><topic>Human Genetics</topic><topic>INDEL Mutation</topic><topic>Introns</topic><topic>Male</topic><topic>Medical Microbiology</topic><topic>Poland</topic><topic>Polymorphism, Genetic</topic><topic>Population genetics</topic><topic>Prion protein</topic><topic>Prions - genetics</topic><topic>Promoter Regions, Genetic</topic><topic>Sequence Analysis, DNA</topic><topic>Zoology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Czarnik, Urszula</creatorcontrib><creatorcontrib>Strychalski, Janusz</creatorcontrib><creatorcontrib>Zabolewicz, Tadeusz</creatorcontrib><creatorcontrib>Pareek, Chandra S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Biochemical genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Czarnik, Urszula</au><au>Strychalski, Janusz</au><au>Zabolewicz, Tadeusz</au><au>Pareek, Chandra S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Populationwide Investigation of Two Indel Polymorphisms at the Prion Protein Gene in Polish Holstein–Friesian Cattle</atitle><jtitle>Biochemical genetics</jtitle><stitle>Biochem Genet</stitle><addtitle>Biochem Genet</addtitle><date>2011-06-01</date><risdate>2011</risdate><volume>49</volume><issue>5-6</issue><spage>303</spage><epage>312</epage><pages>303-312</pages><issn>0006-2928</issn><eissn>1573-4927</eissn><abstract>The allele, genotype, and haplotype frequencies among 837 Polish Holstein–Friesian cattle were determined at two regulatory indel polymorphisms of the
PRNP
gene. Allele frequencies at the 23 bp indel promoter polymorphism were 0.622 (del) and 0.378 (ins), with 0.613 and 0.387 in sires and 0.633 and 0.366 in dams. Allele frequencies at the 12 bp indel intron polymorphism were 0.527 (del) and 0.473 (ins), with 0.529 and 0.471 in sires and 0.543 and 0.456 in dams. Four haplotypes were identified in this population (23–12del, 23–12ins, 23del–12ins, and 23ins–12del). Haplotype 23–12del occurred most frequently in both sire and dam groups. Comparative analysis of Polish Holstein–Friesian and German Holstein populations revealed a similar genetic structure for the 23 bp indel polymorphism and a significantly different one for the 12 bp indel polymorphism. In allele and haplotype analysis, significant differences were observed between the Polish Holstein–Friesian population and a BSE-free German Holstein population.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>21221760</pmid><doi>10.1007/s10528-010-9408-2</doi><tpages>10</tpages></addata></record> |
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| subjects | Animals Biochemistry Biomedical and Life Sciences Biomedicine Cattle Cattle - genetics Encephalopathy, Bovine Spongiform - genetics Female Gene Frequency Gene polymorphism Genetic structure Genetic Variation Haplotypes Human Genetics INDEL Mutation Introns Male Medical Microbiology Poland Polymorphism, Genetic Population genetics Prion protein Prions - genetics Promoter Regions, Genetic Sequence Analysis, DNA Zoology |
| title | Populationwide Investigation of Two Indel Polymorphisms at the Prion Protein Gene in Polish Holstein–Friesian Cattle |
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