Locomotor damage and brain oxidative stress induced by lead exposure are attenuated by gallic acid treatment

We investigated the antioxidant potential of gallic acid (GA), a natural compound found in vegetal sources, on the motor and oxidative damages induced by lead. Rats exposed to lead (50 mg/kg, i.p., once a day, 5 days) were treated with GA (13.5 mg/kg, p.o.) or EDTA (110 mg/kg, i.p.) daily, for 3 day...

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Veröffentlicht in:	Toxicology letters 2011-05, Vol.203 (1), p.74-81
Hauptverfasser:	Reckziegel, Patrícia, Dias, Verônica Tironi, Benvegnú, Dalila, Boufleur, Nardeli, Silva Barcelos, Raquel Cristine, Segat, Hecson Jesser, Pase, Camila Simonetti, dos Santos, Clarissa Marques Moreira, Flores, Érico Marlon Moraes, Bürger, Marilise Escobar
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidant Antioxidants Antioxidants - pharmacology Behavior, Animal - drug effects Biological and medical sciences Brain Brain - drug effects Brain - metabolism Catalase - metabolism Chelating agent Chelating Agents - pharmacology Chemical and industrial products toxicology. Toxic occupational diseases Damage Disease Models, Animal Edetic Acid - pharmacology EDTA Exploratory Behavior - drug effects Gallic acid Gallic Acid - pharmacology Genetic algorithms Lead Lead Poisoning, Nervous System - metabolism Lead Poisoning, Nervous System - physiopathology Lead Poisoning, Nervous System - prevention & control Lead Poisoning, Nervous System - psychology Lipid Peroxidation - drug effects Lipids Male Medical sciences Metals and various inorganic compounds Motor Activity - drug effects Motors Movement damages Nitrates Operating systems Oxidative stress Oxidative Stress - drug effects Porphobilinogen Synthase - metabolism Protein Carbonylation - drug effects Rats Rats, Wistar Toxicology
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