Trypanosoma cruzi: Insights into naphthoquinone effects on growth and proteinase activity

► Naphthoquinones derivatives decrease in vitro growth Trypanosoma cruzi. ► Cytotoxic activities of these compounds on mammalian VERO cells are dose-dependent. ► β-Lapachone is able to inhibit the cysteine-proteinase activity of T. cruzi. ► Epoxy-α-lap is able to inhibit the serine-proteinase activi...

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Veröffentlicht in:	Experimental parasitology 2011, Vol.127 (1), p.160-166
Hauptverfasser:	Bourguignon, Saulo C., Cavalcanti, Danielle F.B., de Souza, Alessandra M.T., Castro, Helena C., Rodrigues, Carlos R., Albuquerque, Magaly G., Santos, Dilvani O., da Silva, Gabriel Gomes, da Silva, Fernando C., Ferreira, Vitor F., de Pinho, Rosa T., Alves, Carlos R.
Format:	Artikel
Sprache:	eng
Schlagworte:	active sites Animals Anti-Infective Agents - pharmacology Biological and medical sciences Cercopithecus aethiops Chagas disease cruzipain Cysteine Endopeptidases Cysteine Proteinase Inhibitors - pharmacology drugs epimastigotes Epoxy-α-lap Fundamental and applied biological sciences. Psychology Human protozoal diseases Infectious diseases Leucine - analogs & derivatives Leucine - pharmacology Life cycle. Host-agent relationship. Pathogenesis Medical sciences molecular models Naphthoquinones Naphthoquinones - pharmacology Parasitic diseases parasitology Peptide Hydrolases - drug effects Peptide Hydrolases - metabolism Protease Inhibitors - pharmacology proteinase inhibitors Proteinases Protozoa Protozoal diseases Protozoan Proteins - antagonists & inhibitors serine proteinases toxicity Trypanosoma cruzi Trypanosoma cruzi - drug effects Trypanosoma cruzi - enzymology Trypanosoma cruzi - growth & development Trypanosomiasis Vero Cells viability β-Lapachone
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