Methylation by protein arginine methyltransferase 1 increases stability of Axin, a negative regulator of Wnt signaling

Axin, a negative regulator of Wnt signaling, is a key scaffold protein for the β-catenin destruction complex. It has been previously shown that multiple post-translational modification enzymes regulate the level of Axin. Here, we provide evidence that protein arginine methyltransferase 1 (PRMT1) dir...

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Veröffentlicht in:	Oncogene 2011-05, Vol.30 (20), p.2379-2389
Hauptverfasser:	Cha, B, Kim, W, Kim, Y K, Hwang, B N, Park, S Y, Yoon, J W, Park, W S, Cho, J W, Bedford, M T, Jho, E-h
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/458/1648 631/80/86 Adaptor Proteins, Signal Transducing - metabolism Apoptosis Arginine Axin Protein beta Catenin - metabolism Biological and medical sciences Cancer Cell Biology Cell cycle Cell Line Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cellular signal transduction DNA methylation Down-regulation Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation Gene Knockdown Techniques Glycogen Glycogen synthase kinase 3 Human Genetics Humans In Vitro Techniques Internal Medicine Kinases Medicine Medicine & Public Health Methylation Methyltransferases Molecular and cellular biology Oncology original-article Physiological aspects Post-translation Protein arginine methyltransferase Protein-Arginine N-Methyltransferases - metabolism Proteins Repressor Proteins - metabolism Signal Transduction Transcription Ubiquitination Wnt protein Wnt Proteins - metabolism β-Catenin
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