Haplotypes in the Interleukin 8 Gene and Their Association with Chronic Periodontitis Susceptibility
Interleukin-8 (IL-8), which is responsible for the migration and activation of neutrophils, is an important inflammatory mediator involved in the initiation and amplification of acute inflammatory reactions and chronic inflammatory processes. IL-8 plays an important role in periodontitis, an inflamm...
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| Veröffentlicht in: | Biochemical genetics 2011-06, Vol.49 (5-6), p.292-302 |
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| creator | Scarel-Caminaga, Raquel M. Kim, Yeon J. Viana, Aline C. Curtis, Karen M. C. Corbi, Sâmia C. T. Sogumo, Patrícia M. Orrico, Silvana R. P. Cirelli, Joni A. |
| description | Interleukin-8 (IL-8), which is responsible for the migration and activation of neutrophils, is an important inflammatory mediator involved in the initiation and amplification of acute inflammatory reactions and chronic inflammatory processes. IL-8 plays an important role in periodontitis, an inflammatory disease characterized by the loss of connective tissue and alveolar bone. The aim of this study was to investigate whether the SNPs rs2227307 (+396) and rs2227306 (+781), and the haplotypes they formed together with the previously investigated rs4073 (−251), were associated with chronic periodontitis susceptibility. Clinical periodontal exams were performed and DNA samples were collected from 493 individuals (223 with periodontitis and 270 controls). Associations between SNPs, haplotypes, and subject phenotypes were analyzed using the χ
2
test followed by multivariate logistic regression modeling. We conclude that the +396TT genotype and the haplotypes ATC/TTC and AGT/TGC were significantly associated with chronic periodontitis susceptibility in Brazilians. |
| doi_str_mv | 10.1007/s10528-010-9407-3 |
| format | Article |
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2
test followed by multivariate logistic regression modeling. We conclude that the +396TT genotype and the haplotypes ATC/TTC and AGT/TGC were significantly associated with chronic periodontitis susceptibility in Brazilians.</description><identifier>ISSN: 0006-2928</identifier><identifier>EISSN: 1573-4927</identifier><identifier>DOI: 10.1007/s10528-010-9407-3</identifier><identifier>PMID: 21188496</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adult ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Brazil ; Case-Control Studies ; Chronic Periodontitis - genetics ; Female ; Genetic Association Studies ; Genetic Predisposition to Disease ; Haplotypes ; Human Genetics ; Humans ; Interleukin-8 - genetics ; Male ; Medical Microbiology ; Middle Aged ; Multivariate Analysis ; Polymorphism, Single Nucleotide ; Regression Analysis ; Zoology</subject><ispartof>Biochemical genetics, 2011-06, Vol.49 (5-6), p.292-302</ispartof><rights>Springer Science+Business Media, LLC 2010</rights><rights>Springer Science+Business Media, LLC 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-ca17920301b376b6f386c18429a7aa14b9307eedaa17fcc92fcf9563de6535543</citedby><cites>FETCH-LOGICAL-c402t-ca17920301b376b6f386c18429a7aa14b9307eedaa17fcc92fcf9563de6535543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10528-010-9407-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10528-010-9407-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21188496$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Scarel-Caminaga, Raquel M.</creatorcontrib><creatorcontrib>Kim, Yeon J.</creatorcontrib><creatorcontrib>Viana, Aline C.</creatorcontrib><creatorcontrib>Curtis, Karen M. C.</creatorcontrib><creatorcontrib>Corbi, Sâmia C. T.</creatorcontrib><creatorcontrib>Sogumo, Patrícia M.</creatorcontrib><creatorcontrib>Orrico, Silvana R. P.</creatorcontrib><creatorcontrib>Cirelli, Joni A.</creatorcontrib><title>Haplotypes in the Interleukin 8 Gene and Their Association with Chronic Periodontitis Susceptibility</title><title>Biochemical genetics</title><addtitle>Biochem Genet</addtitle><addtitle>Biochem Genet</addtitle><description>Interleukin-8 (IL-8), which is responsible for the migration and activation of neutrophils, is an important inflammatory mediator involved in the initiation and amplification of acute inflammatory reactions and chronic inflammatory processes. IL-8 plays an important role in periodontitis, an inflammatory disease characterized by the loss of connective tissue and alveolar bone. The aim of this study was to investigate whether the SNPs rs2227307 (+396) and rs2227306 (+781), and the haplotypes they formed together with the previously investigated rs4073 (−251), were associated with chronic periodontitis susceptibility. Clinical periodontal exams were performed and DNA samples were collected from 493 individuals (223 with periodontitis and 270 controls). Associations between SNPs, haplotypes, and subject phenotypes were analyzed using the χ
2
test followed by multivariate logistic regression modeling. We conclude that the +396TT genotype and the haplotypes ATC/TTC and AGT/TGC were significantly associated with chronic periodontitis susceptibility in Brazilians.</description><subject>Adult</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brazil</subject><subject>Case-Control Studies</subject><subject>Chronic Periodontitis - genetics</subject><subject>Female</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Haplotypes</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Interleukin-8 - genetics</subject><subject>Male</subject><subject>Medical Microbiology</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Regression Analysis</subject><subject>Zoology</subject><issn>0006-2928</issn><issn>1573-4927</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkV1rFDEUhoModq3-AG8keOPV1HxNPi7Lom2hoGC9DpnMGTd1NhmTDLL_3ixbFQriVc4hT56Tw4vQa0ouKCHqfaGkZ7ojlHRGENXxJ2hDe8U7YZh6ijaEENkxw_QZelHKfWsNEeI5OmOUai2M3KDx2i1zqocFCg4R1x3gm1ghz7B-b73GVxABuzjiux2EjC9LST64GlLEP0Pd4e0upxg8_gw5pDHFGmoo-MtaPCw1DGEO9fASPZvcXODVw3mOvn78cLe97m4_Xd1sL287LwirnXdUGUY4oQNXcpAT19JTLZhxyjkqBsOJAhhbrSbvDZv8ZHrJR5A973vBz9G7k3fJ6ccKpdp9aP-YZxchrcVqJRnr24D_k7Ipmaa8kW8fkfdpzbGtcdSZ3nBqGkRPkM-plAyTXXLYu3ywlNhjVPYUlW1R2WNU9ih-8yBehz2Mf178zqYB7ASUdhW_Qf47-d_WXwuonh4</recordid><startdate>20110601</startdate><enddate>20110601</enddate><creator>Scarel-Caminaga, Raquel M.</creator><creator>Kim, Yeon J.</creator><creator>Viana, Aline C.</creator><creator>Curtis, Karen M. 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C. ; Corbi, Sâmia C. T. ; Sogumo, Patrícia M. ; Orrico, Silvana R. 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C.</au><au>Corbi, Sâmia C. T.</au><au>Sogumo, Patrícia M.</au><au>Orrico, Silvana R. P.</au><au>Cirelli, Joni A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Haplotypes in the Interleukin 8 Gene and Their Association with Chronic Periodontitis Susceptibility</atitle><jtitle>Biochemical genetics</jtitle><stitle>Biochem Genet</stitle><addtitle>Biochem Genet</addtitle><date>2011-06-01</date><risdate>2011</risdate><volume>49</volume><issue>5-6</issue><spage>292</spage><epage>302</epage><pages>292-302</pages><issn>0006-2928</issn><eissn>1573-4927</eissn><abstract>Interleukin-8 (IL-8), which is responsible for the migration and activation of neutrophils, is an important inflammatory mediator involved in the initiation and amplification of acute inflammatory reactions and chronic inflammatory processes. IL-8 plays an important role in periodontitis, an inflammatory disease characterized by the loss of connective tissue and alveolar bone. The aim of this study was to investigate whether the SNPs rs2227307 (+396) and rs2227306 (+781), and the haplotypes they formed together with the previously investigated rs4073 (−251), were associated with chronic periodontitis susceptibility. Clinical periodontal exams were performed and DNA samples were collected from 493 individuals (223 with periodontitis and 270 controls). Associations between SNPs, haplotypes, and subject phenotypes were analyzed using the χ
2
test followed by multivariate logistic regression modeling. We conclude that the +396TT genotype and the haplotypes ATC/TTC and AGT/TGC were significantly associated with chronic periodontitis susceptibility in Brazilians.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>21188496</pmid><doi>10.1007/s10528-010-9407-3</doi><tpages>11</tpages></addata></record> |
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| subjects | Adult Biochemistry Biomedical and Life Sciences Biomedicine Brazil Case-Control Studies Chronic Periodontitis - genetics Female Genetic Association Studies Genetic Predisposition to Disease Haplotypes Human Genetics Humans Interleukin-8 - genetics Male Medical Microbiology Middle Aged Multivariate Analysis Polymorphism, Single Nucleotide Regression Analysis Zoology |
| title | Haplotypes in the Interleukin 8 Gene and Their Association with Chronic Periodontitis Susceptibility |
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