Inverse associations between long-term weight change and serum concentrations of persistent organic pollutants
There is emerging evidence that persistent organic pollutants (POPs) can increase the risk of various chronic diseases. As POPs mainly bioaccumulate in adipose tissue, weight change can affect serum concentrations of POPs. However, there are few population-based studies on effects of long-term weigh...
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| Veröffentlicht in: | International Journal of Obesity 2011-05, Vol.35 (5), p.744-747 |
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| container_title | International Journal of Obesity |
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| creator | Lim, J.S Son, H.K Park, S.K Jacobs, D.R. Jr Lee, D.H |
| description | There is emerging evidence that persistent organic pollutants (POPs) can increase the risk of various chronic diseases. As POPs mainly bioaccumulate in adipose tissue, weight change can affect serum concentrations of POPs. However, there are few population-based studies on effects of long-term weight change on serum concentrations of POPs. We examined associations between self-reported weight change over 1 year and 10 years and serum concentrations of seven POPs in 1099 adults aged 40. Serum concentrations of most POPs were higher in those with long-term weight loss, whereas they were lower in those with long-term weight gain. Adjusted correlation coefficients of each POP with weight change for 10 years were -0.23 (P |
| doi_str_mv | 10.1038/ijo.2010.188 |
| format | Article |
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Jr ; Lee, D.H</creator><creatorcontrib>Lim, J.S ; Son, H.K ; Park, S.K ; Jacobs, D.R. Jr ; Lee, D.H</creatorcontrib><description><![CDATA[There is emerging evidence that persistent organic pollutants (POPs) can increase the risk of various chronic diseases. As POPs mainly bioaccumulate in adipose tissue, weight change can affect serum concentrations of POPs. However, there are few population-based studies on effects of long-term weight change on serum concentrations of POPs. We examined associations between self-reported weight change over 1 year and 10 years and serum concentrations of seven POPs in 1099 adults aged 40. Serum concentrations of most POPs were higher in those with long-term weight loss, whereas they were lower in those with long-term weight gain. Adjusted correlation coefficients of each POP with weight change for 10 years were -0.23 (P<0.01) for trans-nonachlor, -0.16 (P<0.01) for p,p′-dichlorodiphenyldichloroethylene, and -0.21 (P<0.01) for beta-hexachlorocyclohexane, -0.16 (P<0.01) for PCB169, -0.20 (P<0.01) for PCB180 and -0.17 (P<0.01) for 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin. Weight change for 1 year showed similar but weaker associations, compared with those of long-term weight changes. Although both beneficial health effects after weight loss and harmful health effects after weight gain are generally expected, changes in serum concentrations of POPs in relation to weight change may act on health in directions opposite to what we expect with weight change.]]></description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/ijo.2010.188</identifier><identifier>PMID: 20820170</identifier><language>eng</language><publisher>London: Nature Publishing Group</publisher><subject>692/699/1702/393 ; 692/700/478/174 ; Adipose tissue ; Adipose tissues ; adults ; Bioaccumulation ; blood serum ; Body fat ; Body weight ; chronic diseases ; correlation ; Correlation coefficient ; Dichlorodiphenyl Dichloroethylene - blood ; Dioxins ; Disease control ; Disease prevention ; Environmental Pollutants - blood ; Epidemiology ; Ethnicity ; Female ; Health aspects ; Health care ; Health Promotion and Disease Prevention ; Hexachlorocyclohexane ; Humans ; Hydrocarbons, Chlorinated - blood ; Internal Medicine ; Lindane - blood ; long term effects ; Male ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Nutrition ; Persistent organic pollutants ; Physiological aspects ; Pollutants ; Polychlorinated Biphenyls - blood ; Polychlorinated Dibenzodioxins - analogs & derivatives ; Polychlorinated Dibenzodioxins - blood ; Population studies ; Preventive medicine ; Public Health ; risk ; Risk Factors ; Self report ; short-communication ; Weight control ; Weight Gain ; Weight Loss ; Xenobiotics - blood</subject><ispartof>International Journal of Obesity, 2011-05, Vol.35 (5), p.744-747</ispartof><rights>Macmillan Publishers Limited 2011</rights><rights>COPYRIGHT 2011 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group May 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c572t-499e479f9c8f614c1314da749d5d2a46af60a410112f42f04a99d7237c37defd3</citedby><cites>FETCH-LOGICAL-c572t-499e479f9c8f614c1314da749d5d2a46af60a410112f42f04a99d7237c37defd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2727,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20820170$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lim, J.S</creatorcontrib><creatorcontrib>Son, H.K</creatorcontrib><creatorcontrib>Park, S.K</creatorcontrib><creatorcontrib>Jacobs, D.R. Jr</creatorcontrib><creatorcontrib>Lee, D.H</creatorcontrib><title>Inverse associations between long-term weight change and serum concentrations of persistent organic pollutants</title><title>International Journal of Obesity</title><addtitle>Int J Obes</addtitle><addtitle>Int J Obes (Lond)</addtitle><description><![CDATA[There is emerging evidence that persistent organic pollutants (POPs) can increase the risk of various chronic diseases. As POPs mainly bioaccumulate in adipose tissue, weight change can affect serum concentrations of POPs. However, there are few population-based studies on effects of long-term weight change on serum concentrations of POPs. We examined associations between self-reported weight change over 1 year and 10 years and serum concentrations of seven POPs in 1099 adults aged 40. Serum concentrations of most POPs were higher in those with long-term weight loss, whereas they were lower in those with long-term weight gain. Adjusted correlation coefficients of each POP with weight change for 10 years were -0.23 (P<0.01) for trans-nonachlor, -0.16 (P<0.01) for p,p′-dichlorodiphenyldichloroethylene, and -0.21 (P<0.01) for beta-hexachlorocyclohexane, -0.16 (P<0.01) for PCB169, -0.20 (P<0.01) for PCB180 and -0.17 (P<0.01) for 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin. Weight change for 1 year showed similar but weaker associations, compared with those of long-term weight changes. Although both beneficial health effects after weight loss and harmful health effects after weight gain are generally expected, changes in serum concentrations of POPs in relation to weight change may act on health in directions opposite to what we expect with weight change.]]></description><subject>692/699/1702/393</subject><subject>692/700/478/174</subject><subject>Adipose tissue</subject><subject>Adipose tissues</subject><subject>adults</subject><subject>Bioaccumulation</subject><subject>blood serum</subject><subject>Body fat</subject><subject>Body weight</subject><subject>chronic diseases</subject><subject>correlation</subject><subject>Correlation coefficient</subject><subject>Dichlorodiphenyl Dichloroethylene - blood</subject><subject>Dioxins</subject><subject>Disease control</subject><subject>Disease prevention</subject><subject>Environmental Pollutants - blood</subject><subject>Epidemiology</subject><subject>Ethnicity</subject><subject>Female</subject><subject>Health aspects</subject><subject>Health care</subject><subject>Health Promotion and Disease Prevention</subject><subject>Hexachlorocyclohexane</subject><subject>Humans</subject><subject>Hydrocarbons, Chlorinated - blood</subject><subject>Internal Medicine</subject><subject>Lindane - blood</subject><subject>long term effects</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Nutrition</subject><subject>Persistent organic pollutants</subject><subject>Physiological aspects</subject><subject>Pollutants</subject><subject>Polychlorinated Biphenyls - blood</subject><subject>Polychlorinated Dibenzodioxins - analogs & derivatives</subject><subject>Polychlorinated Dibenzodioxins - blood</subject><subject>Population studies</subject><subject>Preventive medicine</subject><subject>Public Health</subject><subject>risk</subject><subject>Risk Factors</subject><subject>Self report</subject><subject>short-communication</subject><subject>Weight control</subject><subject>Weight Gain</subject><subject>Weight Loss</subject><subject>Xenobiotics - blood</subject><issn>0307-0565</issn><issn>1476-5497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0s-L1DAUB_Aiijuu3jxrUdCLHfOzaY7L4o-FBQ-655BNXzoZ2mRMUhf_e1M6rq4o0kNp8nkv5PVbVU8x2mJEu7duH7YELV9dd6_aYCbahjMp7lcbRJFoEG_5SfUopT1CiHNEHlYnBHWlRKBN5S_8N4gJap1SME5nF3yqryHfAPh6DH5oMsSpvgE37HJtdtoPBfu-ThDnqTbBG_A5HguDrQ-lnUu5LNYhDto7Ux_COM5Z-5weVw-sHhM8Ob5Pq6v3776cf2wuP324OD-7bAwXJDdMSmBCWmk622JmMMWs14LJnvdEs1bbFmmGEcbEMmIR01L2glBhqOjB9vS0er32PcTwdYaU1eSSgXHUHsKcVCdaQphs-f9l2yLGqBRFvvhD7sMcfblGQZwzJgkt6OWKBj2Cct6GMhuztFRnhLeSYiqWQ7d_UeXpYXJlpGBdWb9T8Oq3gh3oMe9SKENdpn4XvlmhiSGlCFYdopt0_K4wUkteVMmLWvKiSl4Kf3a803w9QX-LfwakgGYFqWyVXx9_XfofDevVe53nCLcNC1rMSp6vxOqg9BBdUlefyyYv-RSUYk5_ABt03Nc</recordid><startdate>20110501</startdate><enddate>20110501</enddate><creator>Lim, J.S</creator><creator>Son, H.K</creator><creator>Park, S.K</creator><creator>Jacobs, D.R. 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Jr</au><au>Lee, D.H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inverse associations between long-term weight change and serum concentrations of persistent organic pollutants</atitle><jtitle>International Journal of Obesity</jtitle><stitle>Int J Obes</stitle><addtitle>Int J Obes (Lond)</addtitle><date>2011-05-01</date><risdate>2011</risdate><volume>35</volume><issue>5</issue><spage>744</spage><epage>747</epage><pages>744-747</pages><issn>0307-0565</issn><eissn>1476-5497</eissn><abstract><![CDATA[There is emerging evidence that persistent organic pollutants (POPs) can increase the risk of various chronic diseases. As POPs mainly bioaccumulate in adipose tissue, weight change can affect serum concentrations of POPs. However, there are few population-based studies on effects of long-term weight change on serum concentrations of POPs. We examined associations between self-reported weight change over 1 year and 10 years and serum concentrations of seven POPs in 1099 adults aged 40. Serum concentrations of most POPs were higher in those with long-term weight loss, whereas they were lower in those with long-term weight gain. Adjusted correlation coefficients of each POP with weight change for 10 years were -0.23 (P<0.01) for trans-nonachlor, -0.16 (P<0.01) for p,p′-dichlorodiphenyldichloroethylene, and -0.21 (P<0.01) for beta-hexachlorocyclohexane, -0.16 (P<0.01) for PCB169, -0.20 (P<0.01) for PCB180 and -0.17 (P<0.01) for 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin. Weight change for 1 year showed similar but weaker associations, compared with those of long-term weight changes. Although both beneficial health effects after weight loss and harmful health effects after weight gain are generally expected, changes in serum concentrations of POPs in relation to weight change may act on health in directions opposite to what we expect with weight change.]]></abstract><cop>London</cop><pub>Nature Publishing Group</pub><pmid>20820170</pmid><doi>10.1038/ijo.2010.188</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 692/699/1702/393 692/700/478/174 Adipose tissue Adipose tissues adults Bioaccumulation blood serum Body fat Body weight chronic diseases correlation Correlation coefficient Dichlorodiphenyl Dichloroethylene - blood Dioxins Disease control Disease prevention Environmental Pollutants - blood Epidemiology Ethnicity Female Health aspects Health care Health Promotion and Disease Prevention Hexachlorocyclohexane Humans Hydrocarbons, Chlorinated - blood Internal Medicine Lindane - blood long term effects Male Medicine Medicine & Public Health Metabolic Diseases Nutrition Persistent organic pollutants Physiological aspects Pollutants Polychlorinated Biphenyls - blood Polychlorinated Dibenzodioxins - analogs & derivatives Polychlorinated Dibenzodioxins - blood Population studies Preventive medicine Public Health risk Risk Factors Self report short-communication Weight control Weight Gain Weight Loss Xenobiotics - blood |
| title | Inverse associations between long-term weight change and serum concentrations of persistent organic pollutants |
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