Elucidating the mechanism of action of tributyltin (TBT) in zebrafish

Tributyltin (TBT), an antifouling agent, has been implicated in the masculinization of fish species worldwide, but the masculinizing mechanism is not fully understood. We have examined the actions of TBT as an endocrine disruptor in zebrafish ( Danio rerio). In HeLa cells transiently co-transfected...

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Veröffentlicht in:	Aquatic toxicology 2011-05, Vol.103 (1), p.25-31
Hauptverfasser:	McGinnis, Courtney L., Crivello, Joseph F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal, plant and microbial ecology Animals Applied ecology Aromatase Biological and medical sciences Biomarkers - metabolism Danio rerio Ecotoxicology, biological effects of pollution Endocrine Disruptors - metabolism Endocrine Disruptors - toxicity Female Freshwater Fundamental and applied biological sciences. Psychology General aspects Gonadal Steroid Hormones - metabolism HeLa Cells Humans Liver - metabolism Male Sex Ratio Trialkyltin Compounds - metabolism Trialkyltin Compounds - toxicity Tributyltin Water Pollutants, Chemical - metabolism Water Pollutants, Chemical - toxicity Xenoandrogen Xenoestrogen Zebrafish Zebrafish - metabolism Zebrafish Proteins - metabolism
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