Ubiquitous hazardous metal lead induces TNF-α in human phagocytic THP-1 cells: Primary role of ERK 1/2

Induction of tumor necrosis factor-α (TNF-α) in response to lead (Pb) exposure has been implicated in its immunotoxicity. However, the molecular mechanism by which Pb upregulates the level of TNF-α is wagely known. An attempt was therefore made to elucidate the mechanistic aspect of TNF-α induction,...

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Veröffentlicht in:	Journal of hazardous materials 2011-05, Vol.189 (1), p.255-264
Hauptverfasser:	Khan, Mohd Imran, Islam, Najmul, Sahasrabuddhe, Amogh A., Mahdi, Abbas Ali, Siddiqui, Huma, Ashquin, Mohd, Ahmad, Iqbal
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Applied sciences Cell Line Exact sciences and technology Focusing half life Hazardous Substances - immunology Hazardous Substances - pharmacology Human Humans Immunotoxicity Inhibitors Kinases lead Lead (metal) Lead - immunology Lead - pharmacology MAPKs mitogen-activated protein kinase Mitogen-Activated Protein Kinase 3 - physiology necrosis Phagocytes - drug effects Phagocytes - metabolism Pollution protein secretion Proteins RNA Stability RNA, Messenger Stability THP-1 TNF-α transcription (genetics) Transcriptional Activation - drug effects tumor necrosis factor-alpha Tumor Necrosis Factor-alpha - genetics
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