Good prognosis of localized osteosarcoma in young patients treated with limb-salvage surgery and chemotherapy
Background The objective of this report was to estimate long‐term outcome and prognostic factors in children and adolescents with osteosarcoma. A large group of osteosarcoma patients were analyzed at our national oncology center. Procedure To evaluate the efficacy of surgery and multiagent chemother...
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| Veröffentlicht in: | Pediatric blood & cancer 2011-09, Vol.57 (3), p.415-422 |
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| creator | Hegyi, Marta Semsei, Agnes F. Jakab, Zsuzsanna Antal, Imre Kiss, Janos Szendroi, Miklos Csoka, Monika Kovacs, Gabor |
| description | Background
The objective of this report was to estimate long‐term outcome and prognostic factors in children and adolescents with osteosarcoma. A large group of osteosarcoma patients were analyzed at our national oncology center.
Procedure
To evaluate the efficacy of surgery and multiagent chemotherapy for treating osteosarcoma, we reviewed 122 cases (65 male, 57 female, mean age 13.8 ± 3.6 years) treated at the Second Department of Pediatrics in Budapest between 1988 and 2006. Demographic parameters, tumor‐related and treatment‐related variables, response, overall survival (OS) and event‐free survival (EFS) were analyzed.
Results
The 5‐year OS was 68% and 5‐year EFS was 62%. OS of patients without metastasis was 79%, while OS with early metastasis was 17%. Survival of patients with amputation (n = 30) was not significantly different from patients with limb‐salvage surgery (n = 82), but all patients without radical surgery died. Gender and histological classification had no prognostic significance. Patients with localized tumors in extremities had increased survival compared to patients with axial skeleton tumors (P = 0.013). Poor histological response to neoadjuvant chemotherapy (rate of survivor tumor cells >10%) was associated with decreased survival (P = 0.018). Patients under 14 years had better EFS than patients over 14 years (P = 0.008).
Conclusions
Our results demonstrate that younger patients with localized osteosarcoma of the extremities who receive limb‐salvage surgery and chemotherapy have an excellent survival. Pediatr Blood Cancer 2011; 57: 415–422. © 2011 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/pbc.23172 |
| format | Article |
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The objective of this report was to estimate long‐term outcome and prognostic factors in children and adolescents with osteosarcoma. A large group of osteosarcoma patients were analyzed at our national oncology center.
Procedure
To evaluate the efficacy of surgery and multiagent chemotherapy for treating osteosarcoma, we reviewed 122 cases (65 male, 57 female, mean age 13.8 ± 3.6 years) treated at the Second Department of Pediatrics in Budapest between 1988 and 2006. Demographic parameters, tumor‐related and treatment‐related variables, response, overall survival (OS) and event‐free survival (EFS) were analyzed.
Results
The 5‐year OS was 68% and 5‐year EFS was 62%. OS of patients without metastasis was 79%, while OS with early metastasis was 17%. Survival of patients with amputation (n = 30) was not significantly different from patients with limb‐salvage surgery (n = 82), but all patients without radical surgery died. Gender and histological classification had no prognostic significance. Patients with localized tumors in extremities had increased survival compared to patients with axial skeleton tumors (P = 0.013). Poor histological response to neoadjuvant chemotherapy (rate of survivor tumor cells >10%) was associated with decreased survival (P = 0.018). Patients under 14 years had better EFS than patients over 14 years (P = 0.008).
Conclusions
Our results demonstrate that younger patients with localized osteosarcoma of the extremities who receive limb‐salvage surgery and chemotherapy have an excellent survival. Pediatr Blood Cancer 2011; 57: 415–422. © 2011 Wiley‐Liss, Inc.</description><identifier>ISSN: 1545-5009</identifier><identifier>EISSN: 1545-5017</identifier><identifier>DOI: 10.1002/pbc.23172</identifier><identifier>PMID: 21563300</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Age Factors ; Amputation - mortality ; Antineoplastic Agents - therapeutic use ; chemotherapy ; Child ; Female ; Humans ; Limb Salvage - mortality ; Male ; Neoplasm Metastasis ; osteosarcoma ; Osteosarcoma - mortality ; Osteosarcoma - therapy ; outcome research ; pediatric oncology ; Prognosis ; Retrospective Studies ; Risk Factors ; Survival Analysis</subject><ispartof>Pediatric blood & cancer, 2011-09, Vol.57 (3), p.415-422</ispartof><rights>Copyright © 2011 Wiley‐Liss, Inc.</rights><rights>Copyright © 2011 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3972-93ca8c0ca9b5d372f4819894b0db203721ef4f0dbd5cbc27313dabadd113dc4f3</citedby><cites>FETCH-LOGICAL-c3972-93ca8c0ca9b5d372f4819894b0db203721ef4f0dbd5cbc27313dabadd113dc4f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpbc.23172$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpbc.23172$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21563300$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hegyi, Marta</creatorcontrib><creatorcontrib>Semsei, Agnes F.</creatorcontrib><creatorcontrib>Jakab, Zsuzsanna</creatorcontrib><creatorcontrib>Antal, Imre</creatorcontrib><creatorcontrib>Kiss, Janos</creatorcontrib><creatorcontrib>Szendroi, Miklos</creatorcontrib><creatorcontrib>Csoka, Monika</creatorcontrib><creatorcontrib>Kovacs, Gabor</creatorcontrib><title>Good prognosis of localized osteosarcoma in young patients treated with limb-salvage surgery and chemotherapy</title><title>Pediatric blood & cancer</title><addtitle>Pediatr. Blood Cancer</addtitle><description>Background
The objective of this report was to estimate long‐term outcome and prognostic factors in children and adolescents with osteosarcoma. A large group of osteosarcoma patients were analyzed at our national oncology center.
Procedure
To evaluate the efficacy of surgery and multiagent chemotherapy for treating osteosarcoma, we reviewed 122 cases (65 male, 57 female, mean age 13.8 ± 3.6 years) treated at the Second Department of Pediatrics in Budapest between 1988 and 2006. Demographic parameters, tumor‐related and treatment‐related variables, response, overall survival (OS) and event‐free survival (EFS) were analyzed.
Results
The 5‐year OS was 68% and 5‐year EFS was 62%. OS of patients without metastasis was 79%, while OS with early metastasis was 17%. Survival of patients with amputation (n = 30) was not significantly different from patients with limb‐salvage surgery (n = 82), but all patients without radical surgery died. Gender and histological classification had no prognostic significance. Patients with localized tumors in extremities had increased survival compared to patients with axial skeleton tumors (P = 0.013). Poor histological response to neoadjuvant chemotherapy (rate of survivor tumor cells >10%) was associated with decreased survival (P = 0.018). Patients under 14 years had better EFS than patients over 14 years (P = 0.008).
Conclusions
Our results demonstrate that younger patients with localized osteosarcoma of the extremities who receive limb‐salvage surgery and chemotherapy have an excellent survival. Pediatr Blood Cancer 2011; 57: 415–422. © 2011 Wiley‐Liss, Inc.</description><subject>Adolescent</subject><subject>Age Factors</subject><subject>Amputation - mortality</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>chemotherapy</subject><subject>Child</subject><subject>Female</subject><subject>Humans</subject><subject>Limb Salvage - mortality</subject><subject>Male</subject><subject>Neoplasm Metastasis</subject><subject>osteosarcoma</subject><subject>Osteosarcoma - mortality</subject><subject>Osteosarcoma - therapy</subject><subject>outcome research</subject><subject>pediatric oncology</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Survival Analysis</subject><issn>1545-5009</issn><issn>1545-5017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtKxDAUhoMo3he-gGQnLqpJ00zbpQ7OKIiKKIqbcJqkM9G2qUmr1qc3Ojo7V-fCd344H0J7lBxRQuLjtpBHMaNpvII2KU94xAlNV5c9yTfQlvfPAR0Rnq2jjZjyEWOEbKJ6aq3CrbOzxnrjsS1xZSVU5lMrbH2nrQcnbQ3YNHiwfTPDLXRGN53HndPQBezddHNcmbqIPFRvMNPY926m3YChUVjOdW27uXbQDjtorYTK693fuo3uJ2d34_Po8np6MT65jCTL0zjKmYRMEgl5wRVL4zLJaJ7lSUFUEZOwoLpMyjAoLgsZp4wyBQUoRUMjk5Jto4NFbnjstde-E7XxUlcVNNr2XmTpiOY040kgDxekdNZ7p0vROlODGwQl4luuCHLFj9zA7v-m9kWt1ZL8sxmA4wXwbio9_J8kbk7Hf5HR4sIE1R_LC3AvYpSylIuHq6m4uRvfTm6frsQj-wJEaJWJ</recordid><startdate>201109</startdate><enddate>201109</enddate><creator>Hegyi, Marta</creator><creator>Semsei, Agnes F.</creator><creator>Jakab, Zsuzsanna</creator><creator>Antal, Imre</creator><creator>Kiss, Janos</creator><creator>Szendroi, Miklos</creator><creator>Csoka, Monika</creator><creator>Kovacs, Gabor</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201109</creationdate><title>Good prognosis of localized osteosarcoma in young patients treated with limb-salvage surgery and chemotherapy</title><author>Hegyi, Marta ; Semsei, Agnes F. ; Jakab, Zsuzsanna ; Antal, Imre ; Kiss, Janos ; Szendroi, Miklos ; Csoka, Monika ; Kovacs, Gabor</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3972-93ca8c0ca9b5d372f4819894b0db203721ef4f0dbd5cbc27313dabadd113dc4f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Age Factors</topic><topic>Amputation - mortality</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>chemotherapy</topic><topic>Child</topic><topic>Female</topic><topic>Humans</topic><topic>Limb Salvage - mortality</topic><topic>Male</topic><topic>Neoplasm Metastasis</topic><topic>osteosarcoma</topic><topic>Osteosarcoma - mortality</topic><topic>Osteosarcoma - therapy</topic><topic>outcome research</topic><topic>pediatric oncology</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Survival Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hegyi, Marta</creatorcontrib><creatorcontrib>Semsei, Agnes F.</creatorcontrib><creatorcontrib>Jakab, Zsuzsanna</creatorcontrib><creatorcontrib>Antal, Imre</creatorcontrib><creatorcontrib>Kiss, Janos</creatorcontrib><creatorcontrib>Szendroi, Miklos</creatorcontrib><creatorcontrib>Csoka, Monika</creatorcontrib><creatorcontrib>Kovacs, Gabor</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric blood & cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hegyi, Marta</au><au>Semsei, Agnes F.</au><au>Jakab, Zsuzsanna</au><au>Antal, Imre</au><au>Kiss, Janos</au><au>Szendroi, Miklos</au><au>Csoka, Monika</au><au>Kovacs, Gabor</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Good prognosis of localized osteosarcoma in young patients treated with limb-salvage surgery and chemotherapy</atitle><jtitle>Pediatric blood & cancer</jtitle><addtitle>Pediatr. Blood Cancer</addtitle><date>2011-09</date><risdate>2011</risdate><volume>57</volume><issue>3</issue><spage>415</spage><epage>422</epage><pages>415-422</pages><issn>1545-5009</issn><eissn>1545-5017</eissn><abstract>Background
The objective of this report was to estimate long‐term outcome and prognostic factors in children and adolescents with osteosarcoma. A large group of osteosarcoma patients were analyzed at our national oncology center.
Procedure
To evaluate the efficacy of surgery and multiagent chemotherapy for treating osteosarcoma, we reviewed 122 cases (65 male, 57 female, mean age 13.8 ± 3.6 years) treated at the Second Department of Pediatrics in Budapest between 1988 and 2006. Demographic parameters, tumor‐related and treatment‐related variables, response, overall survival (OS) and event‐free survival (EFS) were analyzed.
Results
The 5‐year OS was 68% and 5‐year EFS was 62%. OS of patients without metastasis was 79%, while OS with early metastasis was 17%. Survival of patients with amputation (n = 30) was not significantly different from patients with limb‐salvage surgery (n = 82), but all patients without radical surgery died. Gender and histological classification had no prognostic significance. Patients with localized tumors in extremities had increased survival compared to patients with axial skeleton tumors (P = 0.013). Poor histological response to neoadjuvant chemotherapy (rate of survivor tumor cells >10%) was associated with decreased survival (P = 0.018). Patients under 14 years had better EFS than patients over 14 years (P = 0.008).
Conclusions
Our results demonstrate that younger patients with localized osteosarcoma of the extremities who receive limb‐salvage surgery and chemotherapy have an excellent survival. Pediatr Blood Cancer 2011; 57: 415–422. © 2011 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>21563300</pmid><doi>10.1002/pbc.23172</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley-Blackwell Journals; MEDLINE |
| subjects | Adolescent Age Factors Amputation - mortality Antineoplastic Agents - therapeutic use chemotherapy Child Female Humans Limb Salvage - mortality Male Neoplasm Metastasis osteosarcoma Osteosarcoma - mortality Osteosarcoma - therapy outcome research pediatric oncology Prognosis Retrospective Studies Risk Factors Survival Analysis |
| title | Good prognosis of localized osteosarcoma in young patients treated with limb-salvage surgery and chemotherapy |
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