Low homoarginine concentration is a novel risk factor for heart disease
BackgroundHomoarginine is an amino acid which may play a role in nitric oxide and energy metabolism. Low homoarginine concentrations have previously been linked to increased mortality, but the underlying mechanisms remain unknown.ObjectivesTo investigate whether serum homoarginine concentrations are...
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| Veröffentlicht in: | Heart (British Cardiac Society) 2011-08, Vol.97 (15), p.1222-1227 |
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| creator | Pilz, Stefan Meinitzer, Andreas Tomaschitz, Andreas Drechsler, Christiane Ritz, Eberhard Krane, Vera Wanner, Christoph Boehm, Bernhard O März, Winfried |
| description | BackgroundHomoarginine is an amino acid which may play a role in nitric oxide and energy metabolism. Low homoarginine concentrations have previously been linked to increased mortality, but the underlying mechanisms remain unknown.ObjectivesTo investigate whether serum homoarginine concentrations are associated with myocardial function, energy metabolism and fatal events.Design and patientsSerum homoarginine concentrations were measured in 3305 Caucasian patients who were referred for coronary angiography at a tertiary care centre in Germany. After baseline examinations (1997–2000), patients were followed-up with respect to specific causes of death.ResultsHomoarginine concentration correlated positively with angiographic ejection fraction and was inversely associated with N-terminal pro-B-type natriuretic peptide (p |
| doi_str_mv | 10.1136/hrt.2010.220731 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_876191356</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4020954391</sourcerecordid><originalsourceid>FETCH-LOGICAL-b463t-29f80c425a07c2df3b569724c99d7b365ee7c63ddf9cc0f3119c8d5833635d293</originalsourceid><addsrcrecordid>eNqFkElLJDEUgIMo4zZnbxLwMCBUm6WyHYdiXOhGEVSGuYRUKmWn7apoUu3y701T6mEuHh55L_neS_IBcIDRBGPKT-ZxmBCUK0KQoHgD7OCSyyJv_d3MOWWs4IiKbbCb0gIhVCrJf4BtghmTpVA74GwWXuA8dMHEe9_73kEbeuv6IZrBhx76BA3sw7NbwujTA2yNHUKEbY65M3GAjU_OJLcPtlqzTO7nx7oHbk__3FTnxezq7KL6PSvqktOhIKqVyJaEGSQsaVpaM64EKa1SjagpZ84Jy2nTtMpa1FKMlZUNk5Ryyhqi6B74Nc59jOFp5dKgO5-sWy5N78IqaSk4VvnfPJNH_5GLsIp9fpzGQiKBuZQiUycjZWNIKbpWP0bfmfimMdJrxTor1mvFelScOw4_5q7qzjVf_KfTDBQj4NPgXr_OTXzQXFDB9OVdpadcTKvq-p-eZv545Otu8e3t78_SkkE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1780716887</pqid></control><display><type>article</type><title>Low homoarginine concentration is a novel risk factor for heart disease</title><source>MEDLINE</source><source>BMJ Journals - NESLi2</source><source>PubMed Central</source><creator>Pilz, Stefan ; Meinitzer, Andreas ; Tomaschitz, Andreas ; Drechsler, Christiane ; Ritz, Eberhard ; Krane, Vera ; Wanner, Christoph ; Boehm, Bernhard O ; März, Winfried</creator><creatorcontrib>Pilz, Stefan ; Meinitzer, Andreas ; Tomaschitz, Andreas ; Drechsler, Christiane ; Ritz, Eberhard ; Krane, Vera ; Wanner, Christoph ; Boehm, Bernhard O ; März, Winfried</creatorcontrib><description>BackgroundHomoarginine is an amino acid which may play a role in nitric oxide and energy metabolism. Low homoarginine concentrations have previously been linked to increased mortality, but the underlying mechanisms remain unknown.ObjectivesTo investigate whether serum homoarginine concentrations are associated with myocardial function, energy metabolism and fatal events.Design and patientsSerum homoarginine concentrations were measured in 3305 Caucasian patients who were referred for coronary angiography at a tertiary care centre in Germany. After baseline examinations (1997–2000), patients were followed-up with respect to specific causes of death.ResultsHomoarginine concentration correlated positively with angiographic ejection fraction and was inversely associated with N-terminal pro-B-type natriuretic peptide (p<0.001 for both). Variables of energy metabolism (guanidinoacetate and creatine) were significantly associated with homoarginine concentration (p<0.001 for both). Over a median follow-up time of 9.9 years, 991 patients died, including 258 sudden cardiac deaths, 148 heart failure deaths and 105 fatal myocardial infarctions. Multivariable adjusted Cox proportional HRs (with 95% CI) for the first versus the fourth homoarginine quartile were 2.44 (1.60 to 3.73) for sudden cardiac deaths, 3.44 (1.89 to 6.24) for heart failure deaths, and 3.78 (1.77 to 8.06) for fatal myocardial infarctions.ConclusionsHomoarginine deficiency is associated with myocardial dysfunction and significantly increased risk of fatal cardiovascular events and may be related to poor energy metabolism. Further studies are warranted to explore the significance of homoarginine metabolism in risk stratification and treatment of heart diseases.</description><identifier>ISSN: 1355-6037</identifier><identifier>EISSN: 1468-201X</identifier><identifier>DOI: 10.1136/hrt.2010.220731</identifier><identifier>PMID: 21558479</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and British Cardiovascular Society</publisher><subject>amino acids ; Biomarkers - blood ; cardiovascular ; Chromatography, High Pressure Liquid ; Coronary Angiography ; Creatinine - blood ; Cross-Sectional Studies ; Energy Metabolism ; Female ; Follow-Up Studies ; Germany - epidemiology ; Glycine - analogs & derivatives ; Glycine - blood ; Health risk assessment ; Heart attacks ; Heart Diseases - blood ; Heart Diseases - diagnosis ; Heart Diseases - epidemiology ; heart failure ; Homoarginine ; Homoarginine - blood ; Humans ; Incidence ; Male ; Middle Aged ; Mortality ; Myocardium - metabolism ; Prognosis ; Proportional Hazards Models ; prospective ; Retrospective Studies ; Risk Factors ; Severity of Illness Index ; Studies ; Survival Rate - trends ; Time Factors</subject><ispartof>Heart (British Cardiac Society), 2011-08, Vol.97 (15), p.1222-1227</ispartof><rights>2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><rights>Copyright: 2011 (c) 2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b463t-29f80c425a07c2df3b569724c99d7b365ee7c63ddf9cc0f3119c8d5833635d293</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://heart.bmj.com/content/97/15/1222.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://heart.bmj.com/content/97/15/1222.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,315,782,786,3200,23580,27933,27934,77610,77641</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21558479$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pilz, Stefan</creatorcontrib><creatorcontrib>Meinitzer, Andreas</creatorcontrib><creatorcontrib>Tomaschitz, Andreas</creatorcontrib><creatorcontrib>Drechsler, Christiane</creatorcontrib><creatorcontrib>Ritz, Eberhard</creatorcontrib><creatorcontrib>Krane, Vera</creatorcontrib><creatorcontrib>Wanner, Christoph</creatorcontrib><creatorcontrib>Boehm, Bernhard O</creatorcontrib><creatorcontrib>März, Winfried</creatorcontrib><title>Low homoarginine concentration is a novel risk factor for heart disease</title><title>Heart (British Cardiac Society)</title><addtitle>Heart</addtitle><description>BackgroundHomoarginine is an amino acid which may play a role in nitric oxide and energy metabolism. Low homoarginine concentrations have previously been linked to increased mortality, but the underlying mechanisms remain unknown.ObjectivesTo investigate whether serum homoarginine concentrations are associated with myocardial function, energy metabolism and fatal events.Design and patientsSerum homoarginine concentrations were measured in 3305 Caucasian patients who were referred for coronary angiography at a tertiary care centre in Germany. After baseline examinations (1997–2000), patients were followed-up with respect to specific causes of death.ResultsHomoarginine concentration correlated positively with angiographic ejection fraction and was inversely associated with N-terminal pro-B-type natriuretic peptide (p<0.001 for both). Variables of energy metabolism (guanidinoacetate and creatine) were significantly associated with homoarginine concentration (p<0.001 for both). Over a median follow-up time of 9.9 years, 991 patients died, including 258 sudden cardiac deaths, 148 heart failure deaths and 105 fatal myocardial infarctions. Multivariable adjusted Cox proportional HRs (with 95% CI) for the first versus the fourth homoarginine quartile were 2.44 (1.60 to 3.73) for sudden cardiac deaths, 3.44 (1.89 to 6.24) for heart failure deaths, and 3.78 (1.77 to 8.06) for fatal myocardial infarctions.ConclusionsHomoarginine deficiency is associated with myocardial dysfunction and significantly increased risk of fatal cardiovascular events and may be related to poor energy metabolism. Further studies are warranted to explore the significance of homoarginine metabolism in risk stratification and treatment of heart diseases.</description><subject>amino acids</subject><subject>Biomarkers - blood</subject><subject>cardiovascular</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Coronary Angiography</subject><subject>Creatinine - blood</subject><subject>Cross-Sectional Studies</subject><subject>Energy Metabolism</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Germany - epidemiology</subject><subject>Glycine - analogs & derivatives</subject><subject>Glycine - blood</subject><subject>Health risk assessment</subject><subject>Heart attacks</subject><subject>Heart Diseases - blood</subject><subject>Heart Diseases - diagnosis</subject><subject>Heart Diseases - epidemiology</subject><subject>heart failure</subject><subject>Homoarginine</subject><subject>Homoarginine - blood</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Myocardium - metabolism</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>prospective</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Studies</subject><subject>Survival Rate - trends</subject><subject>Time Factors</subject><issn>1355-6037</issn><issn>1468-201X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkElLJDEUgIMo4zZnbxLwMCBUm6WyHYdiXOhGEVSGuYRUKmWn7apoUu3y701T6mEuHh55L_neS_IBcIDRBGPKT-ZxmBCUK0KQoHgD7OCSyyJv_d3MOWWs4IiKbbCb0gIhVCrJf4BtghmTpVA74GwWXuA8dMHEe9_73kEbeuv6IZrBhx76BA3sw7NbwujTA2yNHUKEbY65M3GAjU_OJLcPtlqzTO7nx7oHbk__3FTnxezq7KL6PSvqktOhIKqVyJaEGSQsaVpaM64EKa1SjagpZ84Jy2nTtMpa1FKMlZUNk5Ryyhqi6B74Nc59jOFp5dKgO5-sWy5N78IqaSk4VvnfPJNH_5GLsIp9fpzGQiKBuZQiUycjZWNIKbpWP0bfmfimMdJrxTor1mvFelScOw4_5q7qzjVf_KfTDBQj4NPgXr_OTXzQXFDB9OVdpadcTKvq-p-eZv545Otu8e3t78_SkkE</recordid><startdate>20110801</startdate><enddate>20110801</enddate><creator>Pilz, Stefan</creator><creator>Meinitzer, Andreas</creator><creator>Tomaschitz, Andreas</creator><creator>Drechsler, Christiane</creator><creator>Ritz, Eberhard</creator><creator>Krane, Vera</creator><creator>Wanner, Christoph</creator><creator>Boehm, Bernhard O</creator><creator>März, Winfried</creator><general>BMJ Publishing Group Ltd and British Cardiovascular Society</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20110801</creationdate><title>Low homoarginine concentration is a novel risk factor for heart disease</title><author>Pilz, Stefan ; Meinitzer, Andreas ; Tomaschitz, Andreas ; Drechsler, Christiane ; Ritz, Eberhard ; Krane, Vera ; Wanner, Christoph ; Boehm, Bernhard O ; März, Winfried</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b463t-29f80c425a07c2df3b569724c99d7b365ee7c63ddf9cc0f3119c8d5833635d293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>amino acids</topic><topic>Biomarkers - blood</topic><topic>cardiovascular</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Coronary Angiography</topic><topic>Creatinine - blood</topic><topic>Cross-Sectional Studies</topic><topic>Energy Metabolism</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Germany - epidemiology</topic><topic>Glycine - analogs & derivatives</topic><topic>Glycine - blood</topic><topic>Health risk assessment</topic><topic>Heart attacks</topic><topic>Heart Diseases - blood</topic><topic>Heart Diseases - diagnosis</topic><topic>Heart Diseases - epidemiology</topic><topic>heart failure</topic><topic>Homoarginine</topic><topic>Homoarginine - blood</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Myocardium - metabolism</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>prospective</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>Studies</topic><topic>Survival Rate - trends</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pilz, Stefan</creatorcontrib><creatorcontrib>Meinitzer, Andreas</creatorcontrib><creatorcontrib>Tomaschitz, Andreas</creatorcontrib><creatorcontrib>Drechsler, Christiane</creatorcontrib><creatorcontrib>Ritz, Eberhard</creatorcontrib><creatorcontrib>Krane, Vera</creatorcontrib><creatorcontrib>Wanner, Christoph</creatorcontrib><creatorcontrib>Boehm, Bernhard O</creatorcontrib><creatorcontrib>März, Winfried</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Heart (British Cardiac Society)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pilz, Stefan</au><au>Meinitzer, Andreas</au><au>Tomaschitz, Andreas</au><au>Drechsler, Christiane</au><au>Ritz, Eberhard</au><au>Krane, Vera</au><au>Wanner, Christoph</au><au>Boehm, Bernhard O</au><au>März, Winfried</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low homoarginine concentration is a novel risk factor for heart disease</atitle><jtitle>Heart (British Cardiac Society)</jtitle><addtitle>Heart</addtitle><date>2011-08-01</date><risdate>2011</risdate><volume>97</volume><issue>15</issue><spage>1222</spage><epage>1227</epage><pages>1222-1227</pages><issn>1355-6037</issn><eissn>1468-201X</eissn><abstract>BackgroundHomoarginine is an amino acid which may play a role in nitric oxide and energy metabolism. Low homoarginine concentrations have previously been linked to increased mortality, but the underlying mechanisms remain unknown.ObjectivesTo investigate whether serum homoarginine concentrations are associated with myocardial function, energy metabolism and fatal events.Design and patientsSerum homoarginine concentrations were measured in 3305 Caucasian patients who were referred for coronary angiography at a tertiary care centre in Germany. After baseline examinations (1997–2000), patients were followed-up with respect to specific causes of death.ResultsHomoarginine concentration correlated positively with angiographic ejection fraction and was inversely associated with N-terminal pro-B-type natriuretic peptide (p<0.001 for both). Variables of energy metabolism (guanidinoacetate and creatine) were significantly associated with homoarginine concentration (p<0.001 for both). Over a median follow-up time of 9.9 years, 991 patients died, including 258 sudden cardiac deaths, 148 heart failure deaths and 105 fatal myocardial infarctions. Multivariable adjusted Cox proportional HRs (with 95% CI) for the first versus the fourth homoarginine quartile were 2.44 (1.60 to 3.73) for sudden cardiac deaths, 3.44 (1.89 to 6.24) for heart failure deaths, and 3.78 (1.77 to 8.06) for fatal myocardial infarctions.ConclusionsHomoarginine deficiency is associated with myocardial dysfunction and significantly increased risk of fatal cardiovascular events and may be related to poor energy metabolism. Further studies are warranted to explore the significance of homoarginine metabolism in risk stratification and treatment of heart diseases.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd and British Cardiovascular Society</pub><pmid>21558479</pmid><doi>10.1136/hrt.2010.220731</doi><tpages>6</tpages></addata></record> |
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| subjects | amino acids Biomarkers - blood cardiovascular Chromatography, High Pressure Liquid Coronary Angiography Creatinine - blood Cross-Sectional Studies Energy Metabolism Female Follow-Up Studies Germany - epidemiology Glycine - analogs & derivatives Glycine - blood Health risk assessment Heart attacks Heart Diseases - blood Heart Diseases - diagnosis Heart Diseases - epidemiology heart failure Homoarginine Homoarginine - blood Humans Incidence Male Middle Aged Mortality Myocardium - metabolism Prognosis Proportional Hazards Models prospective Retrospective Studies Risk Factors Severity of Illness Index Studies Survival Rate - trends Time Factors |
| title | Low homoarginine concentration is a novel risk factor for heart disease |
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