Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis

Summary Objectives To investigate the regulation of sclerostin (SOST) in osteoarthritis (OA) and its potential effects on articular cartilage degradation. Methods SOST and other Wnt-β-catenin components were immuno-localised in osteochondral sections of surgically-induced OA in knees of sheep and mi...

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Veröffentlicht in:	Osteoarthritis and cartilage 2011-07, Vol.19 (7), p.874-885
Hauptverfasser:	Chan, B.Y, Fuller, E.S, Russell, A.K, Smith, S.M, Smith, M.M, Jackson, M.T, Cake, M.A, Read, R.A, Bateman, J.F, Sambrook, P.N, Little, C.B
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAMTS Animals Bone Morphogenetic Proteins - metabolism Cartilage Cartilage, Articular - drug effects Cartilage, Articular - metabolism Cartilage, Articular - pathology Chondrocytes - drug effects Chondrocytes - metabolism Humans Interleukin-1alpha - pharmacology Intracellular Signaling Peptides and Proteins - metabolism Mice MMPs Osteoarthritis Osteoarthritis, Knee - metabolism Osteoarthritis, Knee - pathology Rheumatology RNA, Messenger - metabolism Sclerostin Sheep Tumor Necrosis Factor-alpha - pharmacology β-catenin
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