Length-dependent translation of messenger RNA by ribosomes
A simple measure for the efficiency of protein synthesis by ribosomes is provided by the steady state amount of protein per messenger RNA (mRNA), the so-called translational ratio, which is proportional to the translation rate. Taking the degradation of mRNA into account, we show theoretically that...
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| Veröffentlicht in: | Physical review. E, Statistical, nonlinear, and soft matter physics Statistical, nonlinear, and soft matter physics, 2011-04, Vol.83 (4 Pt 1), p.042903-042903, Article 042903 |
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| container_issue | 4 Pt 1 |
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| container_title | Physical review. E, Statistical, nonlinear, and soft matter physics |
| container_volume | 83 |
| creator | Valleriani, Angelo Zhang, Gong Nagar, Apoorva Ignatova, Zoya Lipowsky, Reinhard |
| description | A simple measure for the efficiency of protein synthesis by ribosomes is provided by the steady state amount of protein per messenger RNA (mRNA), the so-called translational ratio, which is proportional to the translation rate. Taking the degradation of mRNA into account, we show theoretically that both the translation rate and the translational ratio decrease with increasing mRNA length, in agreement with available experimental data for the prokaryote Escherichia coli. We also show that, compared to prokaryotes, mRNA degradation in eukaryotes leads to a less rapid decrease of the translational ratio. This finding is consistent with the fact that, compared to prokaryotes, eukaryotes tend to have longer proteins. |
| doi_str_mv | 10.1103/PhysRevE.83.042903 |
| format | Article |
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| source | MEDLINE; American Physical Society Journals |
| subjects | Computer Simulation Models, Chemical Models, Genetic Protein Biosynthesis - genetics Ribosomes - chemistry Ribosomes - genetics RNA, Messenger - chemistry RNA, Messenger - genetics |
| title | Length-dependent translation of messenger RNA by ribosomes |
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