Trastuzumab and Pertuzumab Produce Changes in Morphology and Estrogen Receptor Signaling in Ovarian Cancer Xenografts Revealing New Treatment Strategies

The aim of this study was to investigate the antitumor effects of HER2-directed combination therapy in ovarian cancer xenograft models to evaluate their potential. The combinations of trastuzumab and pertuzumab, and trastuzumab and aromatase inhibitor therapy were investigated. The effects of trastu...

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Veröffentlicht in:	Clinical cancer research 2011-07, Vol.17 (13), p.4451-4461
Hauptverfasser:	FARATIAN, Dana, ZWEEMER, Annelien J. M, HARRISON, David J, LANGDON, Simon P, NAGUMO, Yoko, SIMS, Andrew H, MUIR, Morwenna, DODDS, Michael, MULLEN, Peter, UM, Inhwa, KAY, Charlene, HASMANN, Max
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma, Clear Cell - genetics Adenocarcinoma, Clear Cell - pathology Animals Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal, Humanized Antineoplastic agents Antineoplastic Agents - pharmacology Apoptosis - drug effects Aromatase Inhibitors - pharmacology Biological and medical sciences Carcinoma, Endometrioid - genetics Carcinoma, Endometrioid - pathology Cell Proliferation - drug effects Cystadenocarcinoma, Serous - genetics Cystadenocarcinoma, Serous - pathology Drug Synergism Female Female genital diseases Gene Expression Profiling Gene Expression Regulation, Neoplastic - drug effects Genetic Heterogeneity Gynecology. Andrology. Obstetrics Humans Medical sciences Mice Mice, Nude Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Pharmacology. Drug treatments Phenotype Receptor, ErbB-2 - antagonists & inhibitors Receptors, Estrogen - genetics Receptors, Estrogen - metabolism Signal Transduction - drug effects Trastuzumab Tumor Burden - drug effects Tumors Xenograft Model Antitumor Assays
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