Exposure to Potential CYP450 Pharmacokinetic Drug-Drug Interactions among Osteoarthritis Patients: Incremental Risk of Multiple Prescriptions

Patients taking more than one drug metabolized through the cytochrome P450 (CYP450) enzyme system experience a drug–drug exposure (DDE), which puts them at risk for a potential pharmacokinetic drug–drug interaction (DDI), defined as two or more drugs interacting in such a way that the effectiveness...

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