The Outcomes of First Reoperation for Locoregionally Recurrent/Persistent Papillary Thyroid Carcinoma in Patients Who Initially Underwent Total Thyroidectomy and Remnant Ablation
Context: The primary treatment of locoregionally recurrent/persistent papillary thyroid cancer (PTC) is surgical removal by reoperation. However, there had been only limited number of reports on the outcome of reoperation. Objective: This study was to evaluate the efficacy of the first reoperation f...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2011-07, Vol.96 (7), p.2049-2056 |
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| container_title | The journal of clinical endocrinology and metabolism |
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| creator | Yim, Ji Hye Kim, Won Bae Kim, Eui Young Kim, Won Gu Kim, Tae Yong Ryu, Jin-Sook Gong, Gyungyub Hong, Suck Joon Shong, Young Kee |
| description | Context:
The primary treatment of locoregionally recurrent/persistent papillary thyroid cancer (PTC) is surgical removal by reoperation. However, there had been only limited number of reports on the outcome of reoperation.
Objective:
This study was to evaluate the efficacy of the first reoperation for locoregionally recurrent/persistent papillary thyroid carcinoma and the usefulness of stimulated thyroglobulin for evaluating efficacy of reoperation.
Design and Settings:
This was a retrospective observational cohort study in a tertiary referral hospital.
Patients:
A total of 83 patients, who underwent initial total thyroidectomy and nodal dissection with radioactive iodine remnant ablation, received reoperation for locoregionally recurrent/persistent PTC and were included in this study. Stimulated thyroglobulin levels were assessed before and after reoperation.
Main Outcome Measures:
We assessed biochemical remission (stimulated thyroglobulin |
| doi_str_mv | 10.1210/jc.2010-2298 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_875719077</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>875719077</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5139-abc268f0929b0aee962c2338e078c17551df28f2cce857df39f874c08599a67a3</originalsourceid><addsrcrecordid>eNptkcFuEzEQhlcIREvhxhn5griwre3dje1jFVGoFKkVSgU3y_HOEgevHWyvorwWT8ikSeGCJcsezffPjP1X1VtGLxln9GpjLzlltOZcyWfVOVNtVwumxPPqnFLOaiX497PqVc4bSlnbds3L6oyzjkrWNufV7-UayN1UbBwhkziQG5dyIV8hbiGZ4mIgQ0xkEW1M8AND4_0e03ZKCUK5uoeUXS54Jfdm67w3aU-W632Kridzk6wLcTTEBUwXh1gm39aR3AZX3GOph9BD2h30y1iMf9KCLXHcExN6bDYGg_nrlX8c6HX1YjA-w5vTeVE93Hxazr_Ui7vPt_PrRW071qjarCyfyYEqrlbUAKgZt7xpJFAhLRNdx_qBy4FbC7IT_dCoQYrWUtkpZWbCNBfVh2PdbYq_JshFjy5bwCcGiFPWUnT4z1QIJD8eSZtizgkGvU1uxJ_QjOqDSXpj9cEkfTAJ8XenwtNqhP4v_OQKAu9PgMnW-CGZYF3-xyHS8UYh1x65XfQFjfjppx0kvQbjy1pTXO1MyBo7MyowqnGzg6w5yiD00SYXYJsgZ72JU0J_8_-n_gNGbr6i</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>875719077</pqid></control><display><type>article</type><title>The Outcomes of First Reoperation for Locoregionally Recurrent/Persistent Papillary Thyroid Carcinoma in Patients Who Initially Underwent Total Thyroidectomy and Remnant Ablation</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Journals@Ovid Complete</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Alma/SFX Local Collection</source><creator>Yim, Ji Hye ; Kim, Won Bae ; Kim, Eui Young ; Kim, Won Gu ; Kim, Tae Yong ; Ryu, Jin-Sook ; Gong, Gyungyub ; Hong, Suck Joon ; Shong, Young Kee</creator><creatorcontrib>Yim, Ji Hye ; Kim, Won Bae ; Kim, Eui Young ; Kim, Won Gu ; Kim, Tae Yong ; Ryu, Jin-Sook ; Gong, Gyungyub ; Hong, Suck Joon ; Shong, Young Kee</creatorcontrib><description>Context:
The primary treatment of locoregionally recurrent/persistent papillary thyroid cancer (PTC) is surgical removal by reoperation. However, there had been only limited number of reports on the outcome of reoperation.
Objective:
This study was to evaluate the efficacy of the first reoperation for locoregionally recurrent/persistent papillary thyroid carcinoma and the usefulness of stimulated thyroglobulin for evaluating efficacy of reoperation.
Design and Settings:
This was a retrospective observational cohort study in a tertiary referral hospital.
Patients:
A total of 83 patients, who underwent initial total thyroidectomy and nodal dissection with radioactive iodine remnant ablation, received reoperation for locoregionally recurrent/persistent PTC and were included in this study. Stimulated thyroglobulin levels were assessed before and after reoperation.
Main Outcome Measures:
We assessed biochemical remission (stimulated thyroglobulin <1 ng/ml) after reoperation and evaluated second clinical recurrence-free survival rate according to stimulated thyroglobulin value.
Results:
There was a significant positive correlation between the numbers of resected malignant lymph nodes and the reduction in stimulated thyroglobulin level after reoperation. Biochemical remission was achieved in 51% of patients who underwent first reoperation. Patients with stimulated thyroglobulin level greater than 5 ng/ml after first reoperation had a greater chance of a second clinical recurrence (the estimated 5 yr clinical recurrence free survival rate, 94 ± 3 vs.74 ± 9%, log rank statistics 15.8, df = 1, P < 0.001).
Conclusion:
Surgery is an effective option for managing locally recurrent/persistent PTC. Stimulated thyroglobulin is a useful marker for evaluating efficacy of reoperation and predicting second recurrence in locoregionally recurrent/persistent PTC.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2010-2298</identifier><identifier>PMID: 21508143</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Carcinoma, Papillary - pathology ; Carcinoma, Papillary - surgery ; Disease-Free Survival ; Endocrinopathies ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Male ; Malignant tumors ; Medical sciences ; Middle Aged ; Neoplasm Recurrence, Local - pathology ; Neoplasm Recurrence, Local - surgery ; Remission Induction ; Reoperation ; Retrospective Studies ; Thyroid Neoplasms - pathology ; Thyroid Neoplasms - surgery ; Thyroid. Thyroid axis (diseases) ; Thyroidectomy ; Treatment Outcome ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vertebrates: endocrinology</subject><ispartof>The journal of clinical endocrinology and metabolism, 2011-07, Vol.96 (7), p.2049-2056</ispartof><rights>Copyright © 2011 by The Endocrine Society</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5139-abc268f0929b0aee962c2338e078c17551df28f2cce857df39f874c08599a67a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24335239$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21508143$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yim, Ji Hye</creatorcontrib><creatorcontrib>Kim, Won Bae</creatorcontrib><creatorcontrib>Kim, Eui Young</creatorcontrib><creatorcontrib>Kim, Won Gu</creatorcontrib><creatorcontrib>Kim, Tae Yong</creatorcontrib><creatorcontrib>Ryu, Jin-Sook</creatorcontrib><creatorcontrib>Gong, Gyungyub</creatorcontrib><creatorcontrib>Hong, Suck Joon</creatorcontrib><creatorcontrib>Shong, Young Kee</creatorcontrib><title>The Outcomes of First Reoperation for Locoregionally Recurrent/Persistent Papillary Thyroid Carcinoma in Patients Who Initially Underwent Total Thyroidectomy and Remnant Ablation</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Context:
The primary treatment of locoregionally recurrent/persistent papillary thyroid cancer (PTC) is surgical removal by reoperation. However, there had been only limited number of reports on the outcome of reoperation.
Objective:
This study was to evaluate the efficacy of the first reoperation for locoregionally recurrent/persistent papillary thyroid carcinoma and the usefulness of stimulated thyroglobulin for evaluating efficacy of reoperation.
Design and Settings:
This was a retrospective observational cohort study in a tertiary referral hospital.
Patients:
A total of 83 patients, who underwent initial total thyroidectomy and nodal dissection with radioactive iodine remnant ablation, received reoperation for locoregionally recurrent/persistent PTC and were included in this study. Stimulated thyroglobulin levels were assessed before and after reoperation.
Main Outcome Measures:
We assessed biochemical remission (stimulated thyroglobulin <1 ng/ml) after reoperation and evaluated second clinical recurrence-free survival rate according to stimulated thyroglobulin value.
Results:
There was a significant positive correlation between the numbers of resected malignant lymph nodes and the reduction in stimulated thyroglobulin level after reoperation. Biochemical remission was achieved in 51% of patients who underwent first reoperation. Patients with stimulated thyroglobulin level greater than 5 ng/ml after first reoperation had a greater chance of a second clinical recurrence (the estimated 5 yr clinical recurrence free survival rate, 94 ± 3 vs.74 ± 9%, log rank statistics 15.8, df = 1, P < 0.001).
Conclusion:
Surgery is an effective option for managing locally recurrent/persistent PTC. Stimulated thyroglobulin is a useful marker for evaluating efficacy of reoperation and predicting second recurrence in locoregionally recurrent/persistent PTC.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Papillary - pathology</subject><subject>Carcinoma, Papillary - surgery</subject><subject>Disease-Free Survival</subject><subject>Endocrinopathies</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Male</subject><subject>Malignant tumors</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasm Recurrence, Local - surgery</subject><subject>Remission Induction</subject><subject>Reoperation</subject><subject>Retrospective Studies</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Thyroid Neoplasms - surgery</subject><subject>Thyroid. Thyroid axis (diseases)</subject><subject>Thyroidectomy</subject><subject>Treatment Outcome</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vertebrates: endocrinology</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkcFuEzEQhlcIREvhxhn5griwre3dje1jFVGoFKkVSgU3y_HOEgevHWyvorwWT8ikSeGCJcsezffPjP1X1VtGLxln9GpjLzlltOZcyWfVOVNtVwumxPPqnFLOaiX497PqVc4bSlnbds3L6oyzjkrWNufV7-UayN1UbBwhkziQG5dyIV8hbiGZ4mIgQ0xkEW1M8AND4_0e03ZKCUK5uoeUXS54Jfdm67w3aU-W632Kridzk6wLcTTEBUwXh1gm39aR3AZX3GOph9BD2h30y1iMf9KCLXHcExN6bDYGg_nrlX8c6HX1YjA-w5vTeVE93Hxazr_Ui7vPt_PrRW071qjarCyfyYEqrlbUAKgZt7xpJFAhLRNdx_qBy4FbC7IT_dCoQYrWUtkpZWbCNBfVh2PdbYq_JshFjy5bwCcGiFPWUnT4z1QIJD8eSZtizgkGvU1uxJ_QjOqDSXpj9cEkfTAJ8XenwtNqhP4v_OQKAu9PgMnW-CGZYF3-xyHS8UYh1x65XfQFjfjppx0kvQbjy1pTXO1MyBo7MyowqnGzg6w5yiD00SYXYJsgZ72JU0J_8_-n_gNGbr6i</recordid><startdate>201107</startdate><enddate>201107</enddate><creator>Yim, Ji Hye</creator><creator>Kim, Won Bae</creator><creator>Kim, Eui Young</creator><creator>Kim, Won Gu</creator><creator>Kim, Tae Yong</creator><creator>Ryu, Jin-Sook</creator><creator>Gong, Gyungyub</creator><creator>Hong, Suck Joon</creator><creator>Shong, Young Kee</creator><general>Endocrine Society</general><general>Copyright by The Endocrine Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201107</creationdate><title>The Outcomes of First Reoperation for Locoregionally Recurrent/Persistent Papillary Thyroid Carcinoma in Patients Who Initially Underwent Total Thyroidectomy and Remnant Ablation</title><author>Yim, Ji Hye ; Kim, Won Bae ; Kim, Eui Young ; Kim, Won Gu ; Kim, Tae Yong ; Ryu, Jin-Sook ; Gong, Gyungyub ; Hong, Suck Joon ; Shong, Young Kee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5139-abc268f0929b0aee962c2338e078c17551df28f2cce857df39f874c08599a67a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Papillary - pathology</topic><topic>Carcinoma, Papillary - surgery</topic><topic>Disease-Free Survival</topic><topic>Endocrinopathies</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Male</topic><topic>Malignant tumors</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Neoplasm Recurrence, Local - surgery</topic><topic>Remission Induction</topic><topic>Reoperation</topic><topic>Retrospective Studies</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Thyroid Neoplasms - surgery</topic><topic>Thyroid. Thyroid axis (diseases)</topic><topic>Thyroidectomy</topic><topic>Treatment Outcome</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yim, Ji Hye</creatorcontrib><creatorcontrib>Kim, Won Bae</creatorcontrib><creatorcontrib>Kim, Eui Young</creatorcontrib><creatorcontrib>Kim, Won Gu</creatorcontrib><creatorcontrib>Kim, Tae Yong</creatorcontrib><creatorcontrib>Ryu, Jin-Sook</creatorcontrib><creatorcontrib>Gong, Gyungyub</creatorcontrib><creatorcontrib>Hong, Suck Joon</creatorcontrib><creatorcontrib>Shong, Young Kee</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yim, Ji Hye</au><au>Kim, Won Bae</au><au>Kim, Eui Young</au><au>Kim, Won Gu</au><au>Kim, Tae Yong</au><au>Ryu, Jin-Sook</au><au>Gong, Gyungyub</au><au>Hong, Suck Joon</au><au>Shong, Young Kee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Outcomes of First Reoperation for Locoregionally Recurrent/Persistent Papillary Thyroid Carcinoma in Patients Who Initially Underwent Total Thyroidectomy and Remnant Ablation</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2011-07</date><risdate>2011</risdate><volume>96</volume><issue>7</issue><spage>2049</spage><epage>2056</epage><pages>2049-2056</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract>Context:
The primary treatment of locoregionally recurrent/persistent papillary thyroid cancer (PTC) is surgical removal by reoperation. However, there had been only limited number of reports on the outcome of reoperation.
Objective:
This study was to evaluate the efficacy of the first reoperation for locoregionally recurrent/persistent papillary thyroid carcinoma and the usefulness of stimulated thyroglobulin for evaluating efficacy of reoperation.
Design and Settings:
This was a retrospective observational cohort study in a tertiary referral hospital.
Patients:
A total of 83 patients, who underwent initial total thyroidectomy and nodal dissection with radioactive iodine remnant ablation, received reoperation for locoregionally recurrent/persistent PTC and were included in this study. Stimulated thyroglobulin levels were assessed before and after reoperation.
Main Outcome Measures:
We assessed biochemical remission (stimulated thyroglobulin <1 ng/ml) after reoperation and evaluated second clinical recurrence-free survival rate according to stimulated thyroglobulin value.
Results:
There was a significant positive correlation between the numbers of resected malignant lymph nodes and the reduction in stimulated thyroglobulin level after reoperation. Biochemical remission was achieved in 51% of patients who underwent first reoperation. Patients with stimulated thyroglobulin level greater than 5 ng/ml after first reoperation had a greater chance of a second clinical recurrence (the estimated 5 yr clinical recurrence free survival rate, 94 ± 3 vs.74 ± 9%, log rank statistics 15.8, df = 1, P < 0.001).
Conclusion:
Surgery is an effective option for managing locally recurrent/persistent PTC. Stimulated thyroglobulin is a useful marker for evaluating efficacy of reoperation and predicting second recurrence in locoregionally recurrent/persistent PTC.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>21508143</pmid><doi>10.1210/jc.2010-2298</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0021-972X |
| ispartof | The journal of clinical endocrinology and metabolism, 2011-07, Vol.96 (7), p.2049-2056 |
| issn | 0021-972X 1945-7197 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Biological and medical sciences Carcinoma, Papillary - pathology Carcinoma, Papillary - surgery Disease-Free Survival Endocrinopathies Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Humans Male Malignant tumors Medical sciences Middle Aged Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - surgery Remission Induction Reoperation Retrospective Studies Thyroid Neoplasms - pathology Thyroid Neoplasms - surgery Thyroid. Thyroid axis (diseases) Thyroidectomy Treatment Outcome Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology |
| title | The Outcomes of First Reoperation for Locoregionally Recurrent/Persistent Papillary Thyroid Carcinoma in Patients Who Initially Underwent Total Thyroidectomy and Remnant Ablation |
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