Binding Inhibitors of the Bacterial Sliding Clamp by Design

The bacterial replisome is a target for the development of new antibiotics to combat drug resistant strains. The β2 sliding clamp is an essential component of the replicative machinery, providing a platform for recruitment and function of other replisomal components and ensuring polymerase processiv...

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Veröffentlicht in:	Journal of medicinal chemistry 2011-07, Vol.54 (13), p.4831-4838
Hauptverfasser:	Wijffels, Gene, Johnson, Wynona M, Oakley, Aaron J, Turner, Kathleen, Epa, V. Chandana, Briscoe, Susan J, Polley, Mitchell, Liepa, Andris J, Hofmann, Albert, Buchardt, Jens, Christensen, Caspar, Prosselkov, Pavel, Dalrymple, Brian P, Alewood, Paul F, Jennings, Philip A, Dixon, Nicholas E, Winkler, David A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Binding Sites Crystallography, X-Ray DNA Polymerase III - antagonists & inhibitors DNA Polymerase III - chemistry Drug Design Hydrophobic and Hydrophilic Interactions Ligands Models, Molecular Molecular Mimicry Oligopeptides - chemical synthesis Oligopeptides - chemistry Protein Binding Protein Structure, Tertiary Structure-Activity Relationship Surface Plasmon Resonance
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