SKLB1002, a Novel Potent Inhibitor of VEGF Receptor 2 Signaling, Inhibits Angiogenesis and Tumor Growth In Vivo

VEGF receptor 2 (VEGFR2) inhibitors, as efficient antiangiogenesis agents, have been applied in the cancer treatment. However, currently most of these anticancer drugs suffer some adverse effects. Discovery of novel VEGFR2 inhibitors as anticancer drug candidates is still needed. In this investigati...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical cancer research 2011-07, Vol.17 (13), p.4439-4450
Hauptverfasser:	Zhang, Shuang, Cao, Zhixing, Tian, Hongwei, Shen, Guobo, Ma, Yongping, Xie, Huanzhang, Liu, Yalin, Zhao, Chengjian, Deng, Senyi, Yang, Yang, Zheng, Renlin, Li, Weiwei, Zhang, Na, Liu, Shengyong, Wang, Wei, Dai, Lixia, Shi, Shuai, Cheng, Lin, Pan, Youli, Feng, Shan, Zhao, Xia, Deng, Hongxin, Yang, Shengyong, Wei, Yuquan
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - chemical synthesis Angiogenesis Inhibitors - chemistry Angiogenesis Inhibitors - pharmacology Angiogenesis Inhibitors - therapeutic use Angiogenesis Inhibitors - toxicity Animals Antineoplastic agents Apoptosis - drug effects Biological and medical sciences Cell Line Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Endothelial Cells - drug effects Female General pharmacology Hep G2 Cells Humans Medical sciences Melanoma, Experimental Mice Mice, Nude Neoplasm Invasiveness Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Neovascularization, Pathologic Neovascularization, Physiologic - drug effects Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Quinazolines - chemical synthesis Quinazolines - chemistry Quinazolines - pharmacology Quinazolines - therapeutic use Signal Transduction - drug effects Thiadiazoles - chemical synthesis Thiadiazoles - chemistry Thiadiazoles - pharmacology Thiadiazoles - therapeutic use Tumor Burden - drug effects Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-2 - metabolism Xenograft Model Antitumor Assays Zebrafish - embryology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!