Epidemiologial profile of invasive candidiasis in intensive care units at a university hospital
Invasive candidiasis (IC) epidemiology has changed in critically ill patients and limited data are available in Chile. To describe the epidemiological and microbiological profile of IC in critically ill patients. Observational prospective study conducted from October 2001 to August 2003 in criticall...
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| Veröffentlicht in: | Revista chilena de infectología 2011-04, Vol.28 (2), p.118-122 |
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| creator | Ajenjo H, M Cristina Aquevedo S, Andrés Guzmán D, Ana María Poggi M, Helena Calvo A, Mario Castillo V, Claudia León C, Eugenia Andresen H, Max Labarca L, Jaime |
| description | Invasive candidiasis (IC) epidemiology has changed in critically ill patients and limited data are available in Chile.
To describe the epidemiological and microbiological profile of IC in critically ill patients.
Observational prospective study conducted from October 2001 to August 2003 in critically ill adults with suspected or confirmed IC.
53 patients met criteria for IC, finding 18 (33.9%) candidemias, 22 (41.5%) disseminated IC, and 13 (24.5%) local IC. We identified 8 (44.4%) C. albicans and 10 (55.6%) non-albicans Candida in candidemias. C. tropicalis was the predominant non-albicans species (27.7%). An 88.8 % of Candidas sp recovered in candidemias were fluconazole susceptible. Overall hospital mortality was 24.5%. Mortality in candidemia was significantly lower than in disseminated IC (16.6 vs 31.8%, p = 0.02).
A higher proportion of non-albicans Candida was observed in candidemias from critically ill patients. However, most of these strains were fluconazole susceptible. A lower overall mortality was observed in candidemias. |
| doi_str_mv | 10.4067/S0716-10182011000200003 |
| format | Article |
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To describe the epidemiological and microbiological profile of IC in critically ill patients.
Observational prospective study conducted from October 2001 to August 2003 in critically ill adults with suspected or confirmed IC.
53 patients met criteria for IC, finding 18 (33.9%) candidemias, 22 (41.5%) disseminated IC, and 13 (24.5%) local IC. We identified 8 (44.4%) C. albicans and 10 (55.6%) non-albicans Candida in candidemias. C. tropicalis was the predominant non-albicans species (27.7%). An 88.8 % of Candidas sp recovered in candidemias were fluconazole susceptible. Overall hospital mortality was 24.5%. Mortality in candidemia was significantly lower than in disseminated IC (16.6 vs 31.8%, p = 0.02).
A higher proportion of non-albicans Candida was observed in candidemias from critically ill patients. However, most of these strains were fluconazole susceptible. A lower overall mortality was observed in candidemias.</description><identifier>ISSN: 0716-1018</identifier><identifier>DOI: 10.4067/S0716-10182011000200003</identifier><identifier>PMID: 21720690</identifier><language>spa</language><publisher>Chile</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antifungal Agents - therapeutic use ; Candidiasis, Invasive - drug therapy ; Candidiasis, Invasive - microbiology ; Candidiasis, Invasive - mortality ; Female ; Hospital Mortality ; Hospitals, University ; Humans ; Intensive Care Units - statistics & numerical data ; Male ; Middle Aged ; Prospective Studies ; Risk Factors ; Young Adult</subject><ispartof>Revista chilena de infectología, 2011-04, Vol.28 (2), p.118-122</ispartof><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21720690$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ajenjo H, M Cristina</creatorcontrib><creatorcontrib>Aquevedo S, Andrés</creatorcontrib><creatorcontrib>Guzmán D, Ana María</creatorcontrib><creatorcontrib>Poggi M, Helena</creatorcontrib><creatorcontrib>Calvo A, Mario</creatorcontrib><creatorcontrib>Castillo V, Claudia</creatorcontrib><creatorcontrib>León C, Eugenia</creatorcontrib><creatorcontrib>Andresen H, Max</creatorcontrib><creatorcontrib>Labarca L, Jaime</creatorcontrib><title>Epidemiologial profile of invasive candidiasis in intensive care units at a university hospital</title><title>Revista chilena de infectología</title><addtitle>Rev Chilena Infectol</addtitle><description>Invasive candidiasis (IC) epidemiology has changed in critically ill patients and limited data are available in Chile.
To describe the epidemiological and microbiological profile of IC in critically ill patients.
Observational prospective study conducted from October 2001 to August 2003 in critically ill adults with suspected or confirmed IC.
53 patients met criteria for IC, finding 18 (33.9%) candidemias, 22 (41.5%) disseminated IC, and 13 (24.5%) local IC. We identified 8 (44.4%) C. albicans and 10 (55.6%) non-albicans Candida in candidemias. C. tropicalis was the predominant non-albicans species (27.7%). An 88.8 % of Candidas sp recovered in candidemias were fluconazole susceptible. Overall hospital mortality was 24.5%. Mortality in candidemia was significantly lower than in disseminated IC (16.6 vs 31.8%, p = 0.02).
A higher proportion of non-albicans Candida was observed in candidemias from critically ill patients. However, most of these strains were fluconazole susceptible. A lower overall mortality was observed in candidemias.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antifungal Agents - therapeutic use</subject><subject>Candidiasis, Invasive - drug therapy</subject><subject>Candidiasis, Invasive - microbiology</subject><subject>Candidiasis, Invasive - mortality</subject><subject>Female</subject><subject>Hospital Mortality</subject><subject>Hospitals, University</subject><subject>Humans</subject><subject>Intensive Care Units - statistics & numerical data</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Young Adult</subject><issn>0716-1018</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UMtOwzAQ9AFES-EXwDdOgV0nsZMjqkpBqsQBOEeOvQGjvIidSv17jChIs9rHjEa7y9g1wm0GUt29gEKZIGAhABEARAxIT9jyn1iwc-8_I6Mk4hlbCFQCZAlLVm1GZ6lzQzu8O93ycRoa1xIfGu76vfZuT9zo3jrrYuPjMCJQfyQm4nPvguc6cP1T7mnyLhz4x-BHF3R7wU4b3Xq6POYVe3vYvK4fk93z9ml9v0tGzCAkRhVS5hYpI5MKSZlQcdk6L2VjlbKNgjKjRksFWKPVpjRodJFLQ7q2Uuh0xW5-feMBXzP5UHXOG2pb3dMw-6pQuUIVEZVXR-Vcd2SrcXKdng7V30_SbzagZNU</recordid><startdate>201104</startdate><enddate>201104</enddate><creator>Ajenjo H, M Cristina</creator><creator>Aquevedo S, Andrés</creator><creator>Guzmán D, Ana María</creator><creator>Poggi M, Helena</creator><creator>Calvo A, Mario</creator><creator>Castillo V, Claudia</creator><creator>León C, Eugenia</creator><creator>Andresen H, Max</creator><creator>Labarca L, Jaime</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201104</creationdate><title>Epidemiologial profile of invasive candidiasis in intensive care units at a university hospital</title><author>Ajenjo H, M Cristina ; Aquevedo S, Andrés ; Guzmán D, Ana María ; Poggi M, Helena ; Calvo A, Mario ; Castillo V, Claudia ; León C, Eugenia ; Andresen H, Max ; Labarca L, Jaime</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p140t-c78665d1e4ec326e427027b596fd77df7094efa6701b1dac9c1ca856ceabd62a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>spa</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antifungal Agents - therapeutic use</topic><topic>Candidiasis, Invasive - drug therapy</topic><topic>Candidiasis, Invasive - microbiology</topic><topic>Candidiasis, Invasive - mortality</topic><topic>Female</topic><topic>Hospital Mortality</topic><topic>Hospitals, University</topic><topic>Humans</topic><topic>Intensive Care Units - statistics & numerical data</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Young Adult</topic><toplevel>online_resources</toplevel><creatorcontrib>Ajenjo H, M Cristina</creatorcontrib><creatorcontrib>Aquevedo S, Andrés</creatorcontrib><creatorcontrib>Guzmán D, Ana María</creatorcontrib><creatorcontrib>Poggi M, Helena</creatorcontrib><creatorcontrib>Calvo A, Mario</creatorcontrib><creatorcontrib>Castillo V, Claudia</creatorcontrib><creatorcontrib>León C, Eugenia</creatorcontrib><creatorcontrib>Andresen H, Max</creatorcontrib><creatorcontrib>Labarca L, Jaime</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Revista chilena de infectología</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ajenjo H, M Cristina</au><au>Aquevedo S, Andrés</au><au>Guzmán D, Ana María</au><au>Poggi M, Helena</au><au>Calvo A, Mario</au><au>Castillo V, Claudia</au><au>León C, Eugenia</au><au>Andresen H, Max</au><au>Labarca L, Jaime</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epidemiologial profile of invasive candidiasis in intensive care units at a university hospital</atitle><jtitle>Revista chilena de infectología</jtitle><addtitle>Rev Chilena Infectol</addtitle><date>2011-04</date><risdate>2011</risdate><volume>28</volume><issue>2</issue><spage>118</spage><epage>122</epage><pages>118-122</pages><issn>0716-1018</issn><abstract>Invasive candidiasis (IC) epidemiology has changed in critically ill patients and limited data are available in Chile.
To describe the epidemiological and microbiological profile of IC in critically ill patients.
Observational prospective study conducted from October 2001 to August 2003 in critically ill adults with suspected or confirmed IC.
53 patients met criteria for IC, finding 18 (33.9%) candidemias, 22 (41.5%) disseminated IC, and 13 (24.5%) local IC. We identified 8 (44.4%) C. albicans and 10 (55.6%) non-albicans Candida in candidemias. C. tropicalis was the predominant non-albicans species (27.7%). An 88.8 % of Candidas sp recovered in candidemias were fluconazole susceptible. Overall hospital mortality was 24.5%. Mortality in candidemia was significantly lower than in disseminated IC (16.6 vs 31.8%, p = 0.02).
A higher proportion of non-albicans Candida was observed in candidemias from critically ill patients. However, most of these strains were fluconazole susceptible. A lower overall mortality was observed in candidemias.</abstract><cop>Chile</cop><pmid>21720690</pmid><doi>10.4067/S0716-10182011000200003</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Antifungal Agents - therapeutic use Candidiasis, Invasive - drug therapy Candidiasis, Invasive - microbiology Candidiasis, Invasive - mortality Female Hospital Mortality Hospitals, University Humans Intensive Care Units - statistics & numerical data Male Middle Aged Prospective Studies Risk Factors Young Adult |
| title | Epidemiologial profile of invasive candidiasis in intensive care units at a university hospital |
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