Bone morphogenetic protein-2 and spinal arthrodesis: the basic science perspective on protein interaction with the nervous system

Abstract The use and “off-label” indications for recombinant human bone morphogenetic protein-2 (rhBMP-2) in spinal arthrodesis have been significantly expanded over the last decade. New surgical approaches and pathologies treated often place the exogenous protein near the spinal cord or peripheral...

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