Novel 1,2,4-triazole and Purine Acyclic Cyclopropane Nucleoside Analogues: Synthesis, Antiviral and Cytostatic Activity Evaluations

Background: Several published studies indicate that the acyclic guanine nucleoside analogues possessing bis(1,2-hydroxymethyl) substituted cyclopropane rings mimicking the sugar moiety are potent inhibitors of replication of several herpes viruses. Methods: Established synthetic methods and antivira...

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Veröffentlicht in:	Antiviral chemistry & chemotherapy 2011-08, Vol.21 (6), p.221-230
Hauptverfasser:	Benci, Krešimir, Suhina, Tomislav, Mandić, Leo, Pavelić, Sandra Kraljević, Paravić, Andrea Tomljenović, Pavelić, Krešimir, Balzarini, Jan, Wittine, Karlo, Mintas, Mladen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiretroviral drugs Antiviral Agents - chemical synthesis Antiviral Agents - chemistry Antiviral Agents - pharmacology Breast cancer Breast carcinoma Cell Line, Tumor Cells, Cultured Cytostatic Agents - chemical synthesis Cytostatic Agents - chemistry Cytostatic Agents - pharmacology Cytotoxicity DNA viruses DNA Viruses - drug effects Dogs Drug Evaluation, Preclinical Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Fibroblasts Fibroblasts - cytology Fibroblasts - drug effects Guanine Herpes simplex Herpes viruses Herpesvirus 1, Human - enzymology Herpesvirus 3, Human - enzymology Humans Magnetic Resonance Spectroscopy Mimicry Molecular Structure Nucleoside analogs Phosphorylation Purine Nucleosides - chemistry Purine Nucleosides - pharmacology RNA viruses RNA Viruses - drug effects Structure-Activity Relationship Thymidine Thymidine - metabolism Thymidine Kinase - antagonists & inhibitors Triazoles - chemistry Varicella
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