Methamphetamine-mediated modulation of MOR expression in the SH-SY5Y neuroblastoma cell line

Methamphetamine (METH) has been shown to induce oxidative stress in SH‐SY5Y cells, a neuroblastic, dopaminergic cell line model. In neuronal cells, oxidation of dopamine by auto‐oxidative or enzymatic mechanisms leads to the production of reactive oxygen species (ROS). Neuronal cells treated with ME...

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Veröffentlicht in:	Synapse (New York, N.Y.) N.Y.), 2011-09, Vol.65 (9), p.858-865
Hauptverfasser:	Langsdorf, Erik F., Chang, Sulie L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Cell culture Cell Line, Tumor Cell Survival - drug effects Central Nervous System Stimulants - pharmacology Chelating agents Confocal microscopy Data processing Dopamine Dopamine - metabolism Dose-Response Relationship, Drug Extracellular Fluid - drug effects Extracellular Fluid - metabolism Fluorescence Free radicals Gene Expression Regulation, Neoplastic - drug effects Humans Hydrogen peroxide Hydrogen Peroxide - pharmacology Intracellular signalling Methamphetamine Methamphetamine - pharmacology Microscopy, Confocal - methods mu-opioid receptor Neuroblastoma - metabolism Neuroblastoma - pathology Neuroblastoma cells Opioid receptors (type mu) Oxidative stress Reactive oxygen species Reactive Oxygen Species - metabolism Receptors, Opioid, mu - genetics Receptors, Opioid, mu - metabolism rhodamine Rhodamine 123 - metabolism Synapses Time Factors Vitamin A - pharmacology Vitamin E
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