Selection of HLA-B57-associated Gag A146P mutant by HLA-B∗48:01-restricted Gag140-147-specific CTLs in chronically HIV-1-infected Japanese
We previously showed the possibility that Gag A146P, which is an escape mutant from HLA-B∗57-restricted CTLs, was selected by HLA-B∗48:01-restricted Gag138–147(LI10)-specific CTLs in a Japanese cohort in which HLA-B∗57 individuals were not detected. We herein demonstrated Gag140–147(GI8) to be the o...
Gespeichert in:
| Veröffentlicht in: | Microbes and infection 2011-08, Vol.13 (8), p.766-770 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 770 |
|---|---|
| container_issue | 8 |
| container_start_page | 766 |
| container_title | Microbes and infection |
| container_volume | 13 |
| creator | Naruto, Takuya Murakoshi, Hayato Chikata, Takayuki Koyanagi, Madoka Kawashima, Yuka Gatanaga, Hiroyuki Oka, Shinichi Takiguchi, Masafumi |
| description | We previously showed the possibility that Gag A146P, which is an escape mutant from HLA-B∗57-restricted CTLs, was selected by HLA-B∗48:01-restricted Gag138–147(LI10)-specific CTLs in a Japanese cohort in which HLA-B∗57 individuals were not detected. We herein demonstrated Gag140–147(GI8) to be the optimal epitope rather than LI10 and that GI8-specific T cells failed to recognize the A146P mutant virus-infected cells. The sequence analysis of Gag146 in 261 chronically HIV-1-infected Japanese showed the accumulation of the A146P mutation in HLA-B∗48:01
+ individuals. These findings together indicate that the A146P mutant is accumulating in Japanese by selection by GI8-specific CTLs. |
| doi_str_mv | 10.1016/j.micinf.2011.03.009 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_875488669</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S128645791100092X</els_id><sourcerecordid>875488669</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3020-65255c621c41a372b45130e81d8ce1e82aaec1d9fc58b057f814b449244b2f4d3</originalsourceid><addsrcrecordid>eNp9kc1u1DAUhSNERUvhDRDKBrFy8PVP4rBAGkbQH40EEgWxs5ybG_AoP4OdQeobsGDP-_EkdZsBdqx8F985Pjony54AL4BD-WJbDB792BWCAxRcFpzX97ITqMqaVaA-30-3MCVTuqqPs4cxbjkHXZXqQXYsQFWylvwk-_mBesLZT2M-dfn5ZsVe64q5GCf0bqY2P3Nf8hWo8n0-7Gc3znlzvWC_f_xS5iUHFijOweMBBsVZcmdxR-g7j_n6ahNzP-b4NUyjR9f3yeDiEwOWwtOd7NLt3EiRHmVHnesjPT68p9nHt2-u1uds8-7sYr3aMJRccFZqoTWWAlCBk5VolAbJyUBrkICMcI4Q2rpDbRquq86AapSqhVKN6FQrT7Pni-8uTN_2Kb4dfETq-5Ri2kdrKq2MKcs6kWohMUwxBursLvjBhWsL3N7OYLd2mcHezmC5tGmGJHt6-GDfDNT-Ff3pPQHPDoCLqZIuuBF9_McpKaXQInGvFo5SHd89BRvR04jU-pC6s-3k_5_kBubqpE8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>875488669</pqid></control><display><type>article</type><title>Selection of HLA-B57-associated Gag A146P mutant by HLA-B∗48:01-restricted Gag140-147-specific CTLs in chronically HIV-1-infected Japanese</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Naruto, Takuya ; Murakoshi, Hayato ; Chikata, Takayuki ; Koyanagi, Madoka ; Kawashima, Yuka ; Gatanaga, Hiroyuki ; Oka, Shinichi ; Takiguchi, Masafumi</creator><creatorcontrib>Naruto, Takuya ; Murakoshi, Hayato ; Chikata, Takayuki ; Koyanagi, Madoka ; Kawashima, Yuka ; Gatanaga, Hiroyuki ; Oka, Shinichi ; Takiguchi, Masafumi</creatorcontrib><description>We previously showed the possibility that Gag A146P, which is an escape mutant from HLA-B∗57-restricted CTLs, was selected by HLA-B∗48:01-restricted Gag138–147(LI10)-specific CTLs in a Japanese cohort in which HLA-B∗57 individuals were not detected. We herein demonstrated Gag140–147(GI8) to be the optimal epitope rather than LI10 and that GI8-specific T cells failed to recognize the A146P mutant virus-infected cells. The sequence analysis of Gag146 in 261 chronically HIV-1-infected Japanese showed the accumulation of the A146P mutation in HLA-B∗48:01
+ individuals. These findings together indicate that the A146P mutant is accumulating in Japanese by selection by GI8-specific CTLs.</description><identifier>ISSN: 1286-4579</identifier><identifier>EISSN: 1769-714X</identifier><identifier>DOI: 10.1016/j.micinf.2011.03.009</identifier><identifier>PMID: 21473930</identifier><language>eng</language><publisher>Kidlington: Elsevier SAS</publisher><subject>Biological and medical sciences ; Cohort Studies ; CTL ; Escape ; Fundamental and applied biological sciences. Psychology ; gag Gene Products, Human Immunodeficiency Virus - genetics ; gag Gene Products, Human Immunodeficiency Virus - immunology ; HIV-1 ; HIV-1 - genetics ; HIV-1 - immunology ; HLA-B Antigens - genetics ; HLA-B Antigens - immunology ; HLA-B Antigens - metabolism ; HLA-B∗48:01 ; HLA-B∗57 ; Host-Pathogen Interactions - immunology ; Human viral diseases ; Humans ; Infectious diseases ; Japan ; Medical sciences ; Microbiology ; Miscellaneous ; Mutation ; Peptides ; RNA, Viral - blood ; RNA, Viral - genetics ; Sequence Analysis, RNA ; Statistics, Nonparametric ; T-Lymphocytes, Cytotoxic - immunology ; T-Lymphocytes, Cytotoxic - metabolism ; T-Lymphocytes, Cytotoxic - virology ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Virology</subject><ispartof>Microbes and infection, 2011-08, Vol.13 (8), p.766-770</ispartof><rights>2011 Institut Pasteur</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Institut Pasteur. Published by Elsevier SAS. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3020-65255c621c41a372b45130e81d8ce1e82aaec1d9fc58b057f814b449244b2f4d3</citedby><cites>FETCH-LOGICAL-c3020-65255c621c41a372b45130e81d8ce1e82aaec1d9fc58b057f814b449244b2f4d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S128645791100092X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24333252$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21473930$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Naruto, Takuya</creatorcontrib><creatorcontrib>Murakoshi, Hayato</creatorcontrib><creatorcontrib>Chikata, Takayuki</creatorcontrib><creatorcontrib>Koyanagi, Madoka</creatorcontrib><creatorcontrib>Kawashima, Yuka</creatorcontrib><creatorcontrib>Gatanaga, Hiroyuki</creatorcontrib><creatorcontrib>Oka, Shinichi</creatorcontrib><creatorcontrib>Takiguchi, Masafumi</creatorcontrib><title>Selection of HLA-B57-associated Gag A146P mutant by HLA-B∗48:01-restricted Gag140-147-specific CTLs in chronically HIV-1-infected Japanese</title><title>Microbes and infection</title><addtitle>Microbes Infect</addtitle><description>We previously showed the possibility that Gag A146P, which is an escape mutant from HLA-B∗57-restricted CTLs, was selected by HLA-B∗48:01-restricted Gag138–147(LI10)-specific CTLs in a Japanese cohort in which HLA-B∗57 individuals were not detected. We herein demonstrated Gag140–147(GI8) to be the optimal epitope rather than LI10 and that GI8-specific T cells failed to recognize the A146P mutant virus-infected cells. The sequence analysis of Gag146 in 261 chronically HIV-1-infected Japanese showed the accumulation of the A146P mutation in HLA-B∗48:01
+ individuals. These findings together indicate that the A146P mutant is accumulating in Japanese by selection by GI8-specific CTLs.</description><subject>Biological and medical sciences</subject><subject>Cohort Studies</subject><subject>CTL</subject><subject>Escape</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>gag Gene Products, Human Immunodeficiency Virus - genetics</subject><subject>gag Gene Products, Human Immunodeficiency Virus - immunology</subject><subject>HIV-1</subject><subject>HIV-1 - genetics</subject><subject>HIV-1 - immunology</subject><subject>HLA-B Antigens - genetics</subject><subject>HLA-B Antigens - immunology</subject><subject>HLA-B Antigens - metabolism</subject><subject>HLA-B∗48:01</subject><subject>HLA-B∗57</subject><subject>Host-Pathogen Interactions - immunology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Japan</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Mutation</subject><subject>Peptides</subject><subject>RNA, Viral - blood</subject><subject>RNA, Viral - genetics</subject><subject>Sequence Analysis, RNA</subject><subject>Statistics, Nonparametric</subject><subject>T-Lymphocytes, Cytotoxic - immunology</subject><subject>T-Lymphocytes, Cytotoxic - metabolism</subject><subject>T-Lymphocytes, Cytotoxic - virology</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><subject>Virology</subject><issn>1286-4579</issn><issn>1769-714X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhSNERUvhDRDKBrFy8PVP4rBAGkbQH40EEgWxs5ybG_AoP4OdQeobsGDP-_EkdZsBdqx8F985Pjony54AL4BD-WJbDB792BWCAxRcFpzX97ITqMqaVaA-30-3MCVTuqqPs4cxbjkHXZXqQXYsQFWylvwk-_mBesLZT2M-dfn5ZsVe64q5GCf0bqY2P3Nf8hWo8n0-7Gc3znlzvWC_f_xS5iUHFijOweMBBsVZcmdxR-g7j_n6ahNzP-b4NUyjR9f3yeDiEwOWwtOd7NLt3EiRHmVHnesjPT68p9nHt2-u1uds8-7sYr3aMJRccFZqoTWWAlCBk5VolAbJyUBrkICMcI4Q2rpDbRquq86AapSqhVKN6FQrT7Pni-8uTN_2Kb4dfETq-5Ri2kdrKq2MKcs6kWohMUwxBursLvjBhWsL3N7OYLd2mcHezmC5tGmGJHt6-GDfDNT-Ff3pPQHPDoCLqZIuuBF9_McpKaXQInGvFo5SHd89BRvR04jU-pC6s-3k_5_kBubqpE8</recordid><startdate>201108</startdate><enddate>201108</enddate><creator>Naruto, Takuya</creator><creator>Murakoshi, Hayato</creator><creator>Chikata, Takayuki</creator><creator>Koyanagi, Madoka</creator><creator>Kawashima, Yuka</creator><creator>Gatanaga, Hiroyuki</creator><creator>Oka, Shinichi</creator><creator>Takiguchi, Masafumi</creator><general>Elsevier SAS</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201108</creationdate><title>Selection of HLA-B57-associated Gag A146P mutant by HLA-B∗48:01-restricted Gag140-147-specific CTLs in chronically HIV-1-infected Japanese</title><author>Naruto, Takuya ; Murakoshi, Hayato ; Chikata, Takayuki ; Koyanagi, Madoka ; Kawashima, Yuka ; Gatanaga, Hiroyuki ; Oka, Shinichi ; Takiguchi, Masafumi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3020-65255c621c41a372b45130e81d8ce1e82aaec1d9fc58b057f814b449244b2f4d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Biological and medical sciences</topic><topic>Cohort Studies</topic><topic>CTL</topic><topic>Escape</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>gag Gene Products, Human Immunodeficiency Virus - genetics</topic><topic>gag Gene Products, Human Immunodeficiency Virus - immunology</topic><topic>HIV-1</topic><topic>HIV-1 - genetics</topic><topic>HIV-1 - immunology</topic><topic>HLA-B Antigens - genetics</topic><topic>HLA-B Antigens - immunology</topic><topic>HLA-B Antigens - metabolism</topic><topic>HLA-B∗48:01</topic><topic>HLA-B∗57</topic><topic>Host-Pathogen Interactions - immunology</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Japan</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Mutation</topic><topic>Peptides</topic><topic>RNA, Viral - blood</topic><topic>RNA, Viral - genetics</topic><topic>Sequence Analysis, RNA</topic><topic>Statistics, Nonparametric</topic><topic>T-Lymphocytes, Cytotoxic - immunology</topic><topic>T-Lymphocytes, Cytotoxic - metabolism</topic><topic>T-Lymphocytes, Cytotoxic - virology</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Naruto, Takuya</creatorcontrib><creatorcontrib>Murakoshi, Hayato</creatorcontrib><creatorcontrib>Chikata, Takayuki</creatorcontrib><creatorcontrib>Koyanagi, Madoka</creatorcontrib><creatorcontrib>Kawashima, Yuka</creatorcontrib><creatorcontrib>Gatanaga, Hiroyuki</creatorcontrib><creatorcontrib>Oka, Shinichi</creatorcontrib><creatorcontrib>Takiguchi, Masafumi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Microbes and infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Naruto, Takuya</au><au>Murakoshi, Hayato</au><au>Chikata, Takayuki</au><au>Koyanagi, Madoka</au><au>Kawashima, Yuka</au><au>Gatanaga, Hiroyuki</au><au>Oka, Shinichi</au><au>Takiguchi, Masafumi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Selection of HLA-B57-associated Gag A146P mutant by HLA-B∗48:01-restricted Gag140-147-specific CTLs in chronically HIV-1-infected Japanese</atitle><jtitle>Microbes and infection</jtitle><addtitle>Microbes Infect</addtitle><date>2011-08</date><risdate>2011</risdate><volume>13</volume><issue>8</issue><spage>766</spage><epage>770</epage><pages>766-770</pages><issn>1286-4579</issn><eissn>1769-714X</eissn><abstract>We previously showed the possibility that Gag A146P, which is an escape mutant from HLA-B∗57-restricted CTLs, was selected by HLA-B∗48:01-restricted Gag138–147(LI10)-specific CTLs in a Japanese cohort in which HLA-B∗57 individuals were not detected. We herein demonstrated Gag140–147(GI8) to be the optimal epitope rather than LI10 and that GI8-specific T cells failed to recognize the A146P mutant virus-infected cells. The sequence analysis of Gag146 in 261 chronically HIV-1-infected Japanese showed the accumulation of the A146P mutation in HLA-B∗48:01
+ individuals. These findings together indicate that the A146P mutant is accumulating in Japanese by selection by GI8-specific CTLs.</abstract><cop>Kidlington</cop><pub>Elsevier SAS</pub><pmid>21473930</pmid><doi>10.1016/j.micinf.2011.03.009</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1286-4579 |
| ispartof | Microbes and infection, 2011-08, Vol.13 (8), p.766-770 |
| issn | 1286-4579 1769-714X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_875488669 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Biological and medical sciences Cohort Studies CTL Escape Fundamental and applied biological sciences. Psychology gag Gene Products, Human Immunodeficiency Virus - genetics gag Gene Products, Human Immunodeficiency Virus - immunology HIV-1 HIV-1 - genetics HIV-1 - immunology HLA-B Antigens - genetics HLA-B Antigens - immunology HLA-B Antigens - metabolism HLA-B∗48:01 HLA-B∗57 Host-Pathogen Interactions - immunology Human viral diseases Humans Infectious diseases Japan Medical sciences Microbiology Miscellaneous Mutation Peptides RNA, Viral - blood RNA, Viral - genetics Sequence Analysis, RNA Statistics, Nonparametric T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Cytotoxic - metabolism T-Lymphocytes, Cytotoxic - virology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Virology |
| title | Selection of HLA-B57-associated Gag A146P mutant by HLA-B∗48:01-restricted Gag140-147-specific CTLs in chronically HIV-1-infected Japanese |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T23%3A08%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Selection%20of%20HLA-B57-associated%20Gag%20A146P%20mutant%20by%20HLA-B%E2%88%9748:01-restricted%20Gag140-147-specific%20CTLs%20in%20chronically%20HIV-1-infected%20Japanese&rft.jtitle=Microbes%20and%20infection&rft.au=Naruto,%20Takuya&rft.date=2011-08&rft.volume=13&rft.issue=8&rft.spage=766&rft.epage=770&rft.pages=766-770&rft.issn=1286-4579&rft.eissn=1769-714X&rft_id=info:doi/10.1016/j.micinf.2011.03.009&rft_dat=%3Cproquest_cross%3E875488669%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=875488669&rft_id=info:pmid/21473930&rft_els_id=S128645791100092X&rfr_iscdi=true |