Beneficial Effects of Dietary Fish-Oil-Derived Monounsaturated Fatty Acids on Metabolic Syndrome Risk Factors and Insulin Resistance in Mice
The aim of this study was to elucidate the effect of fish-oil-derived monounsaturated fatty acids (MUFAs) containing large amounts of C20:1 and C22:1 isomers on metabolic disorders in mice. Male C57BL/6J mice were fed a 32% lard diet (control) or a 27% lard plus 5% saury-oil-derived MUFA diet for 6...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 2011-07, Vol.59 (13), p.7482-7489 |
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| container_issue | 13 |
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| container_title | Journal of agricultural and food chemistry |
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| creator | Yang, Zhi-Hong Miyahara, Hiroko Mori, Tetsu Doisaki, Nobushige Hatanaka, Akimasa |
| description | The aim of this study was to elucidate the effect of fish-oil-derived monounsaturated fatty acids (MUFAs) containing large amounts of C20:1 and C22:1 isomers on metabolic disorders in mice. Male C57BL/6J mice were fed a 32% lard diet (control) or a 27% lard plus 5% saury-oil-derived MUFA diet for 6 weeks. Dietary MUFA improved insulin resistance and alleviated metabolic syndrome risk factors by reducing blood glucose and lipids. These favorable changes may be attributed to an improved adipocytokine profile. MUFA ingestion resulted in favorable changes in mRNA expression of genes involved in glucose/lipid metabolism (SCD-1, CPT1a, UCPs, and CS) as well as inflammation (MAC1, MMP3, and SAA3) and alterations in fatty acid composition. Our data suggest that marine MUFA improved glucose/lipid homeostasis and hindered the development of metabolic syndrome in obese mice. |
| doi_str_mv | 10.1021/jf201496h |
| format | Article |
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Male C57BL/6J mice were fed a 32% lard diet (control) or a 27% lard plus 5% saury-oil-derived MUFA diet for 6 weeks. Dietary MUFA improved insulin resistance and alleviated metabolic syndrome risk factors by reducing blood glucose and lipids. These favorable changes may be attributed to an improved adipocytokine profile. MUFA ingestion resulted in favorable changes in mRNA expression of genes involved in glucose/lipid metabolism (SCD-1, CPT1a, UCPs, and CS) as well as inflammation (MAC1, MMP3, and SAA3) and alterations in fatty acid composition. Our data suggest that marine MUFA improved glucose/lipid homeostasis and hindered the development of metabolic syndrome in obese mice.</description><identifier>ISSN: 0021-8561</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/jf201496h</identifier><identifier>PMID: 21627145</identifier><identifier>CODEN: JAFCAU</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Animals ; Biological and medical sciences ; Blood Glucose - analysis ; Dietary Fats - administration & dosage ; Dietary Fats, Unsaturated - administration & dosage ; Fat industries ; Fatty Acids, Monounsaturated - administration & dosage ; Fish Oils - chemistry ; Food industries ; Fundamental and applied biological sciences. Psychology ; Insulin Resistance ; Lipid A - blood ; Male ; Metabolic Syndrome - prevention & control ; Mice ; Mice, Inbred C57BL ; Molecular Nutrition ; Obesity - complications</subject><ispartof>Journal of agricultural and food chemistry, 2011-07, Vol.59 (13), p.7482-7489</ispartof><rights>Copyright © 2011 American Chemical Society</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a410t-3be91a6d10bc479144e52c6973798878773e7b2d1cd44ce5939a6530e784c2f13</citedby><cites>FETCH-LOGICAL-a410t-3be91a6d10bc479144e52c6973798878773e7b2d1cd44ce5939a6530e784c2f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jf201496h$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jf201496h$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24322153$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21627145$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Zhi-Hong</creatorcontrib><creatorcontrib>Miyahara, Hiroko</creatorcontrib><creatorcontrib>Mori, Tetsu</creatorcontrib><creatorcontrib>Doisaki, Nobushige</creatorcontrib><creatorcontrib>Hatanaka, Akimasa</creatorcontrib><title>Beneficial Effects of Dietary Fish-Oil-Derived Monounsaturated Fatty Acids on Metabolic Syndrome Risk Factors and Insulin Resistance in Mice</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>The aim of this study was to elucidate the effect of fish-oil-derived monounsaturated fatty acids (MUFAs) containing large amounts of C20:1 and C22:1 isomers on metabolic disorders in mice. Male C57BL/6J mice were fed a 32% lard diet (control) or a 27% lard plus 5% saury-oil-derived MUFA diet for 6 weeks. Dietary MUFA improved insulin resistance and alleviated metabolic syndrome risk factors by reducing blood glucose and lipids. These favorable changes may be attributed to an improved adipocytokine profile. MUFA ingestion resulted in favorable changes in mRNA expression of genes involved in glucose/lipid metabolism (SCD-1, CPT1a, UCPs, and CS) as well as inflammation (MAC1, MMP3, and SAA3) and alterations in fatty acid composition. Our data suggest that marine MUFA improved glucose/lipid homeostasis and hindered the development of metabolic syndrome in obese mice.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - analysis</subject><subject>Dietary Fats - administration & dosage</subject><subject>Dietary Fats, Unsaturated - administration & dosage</subject><subject>Fat industries</subject><subject>Fatty Acids, Monounsaturated - administration & dosage</subject><subject>Fish Oils - chemistry</subject><subject>Food industries</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Insulin Resistance</subject><subject>Lipid A - blood</subject><subject>Male</subject><subject>Metabolic Syndrome - prevention & control</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Molecular Nutrition</subject><subject>Obesity - complications</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkMFu1DAQhi0EotvCgRdAviDUQ8B27Ng5lrYLlbqqVOAcOc5Y9ZK1i8dB2nfgoTHq0l44jUbzzT-aj5A3nH3gTPCPWy8Yl31394ysuBKsUZyb52TF6rAxquNH5BhxyxgzSrOX5EjwTmgu1Yr8_gQRfHDBzvTSe3AFafL0IkCxeU_XAe-amzA3F5DDL5joJsW0RLRlybbUfm1L2dMzF6a6F-mmro1pDo5-3ccppx3Q24A_KuZKykhtnOhVxGUOkd4CBiw2OqC12wQHr8gLb2eE14d6Qr6vL7-df2mubz5fnZ9dN1ZyVpp2hJ7bbuJsdFL3XEpQwnW9bnVvjDZat6BHMXE3SelA9W1vO9Uy0EY64Xl7Qt4_5N7n9HMBLMMuoIN5thHSgoPRSpqa1VXy9IF0OSFm8MN9DrtqZuBs-Ot-eHRf2beH1GXcwfRI_pNdgXcHwKKzs8_194BPnGyF4Kp94qzDYZuWHKuM_xz8A7wJl8k</recordid><startdate>20110713</startdate><enddate>20110713</enddate><creator>Yang, Zhi-Hong</creator><creator>Miyahara, Hiroko</creator><creator>Mori, Tetsu</creator><creator>Doisaki, Nobushige</creator><creator>Hatanaka, Akimasa</creator><general>American Chemical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110713</creationdate><title>Beneficial Effects of Dietary Fish-Oil-Derived Monounsaturated Fatty Acids on Metabolic Syndrome Risk Factors and Insulin Resistance in Mice</title><author>Yang, Zhi-Hong ; Miyahara, Hiroko ; Mori, Tetsu ; Doisaki, Nobushige ; Hatanaka, Akimasa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a410t-3be91a6d10bc479144e52c6973798878773e7b2d1cd44ce5939a6530e784c2f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - analysis</topic><topic>Dietary Fats - administration & dosage</topic><topic>Dietary Fats, Unsaturated - administration & dosage</topic><topic>Fat industries</topic><topic>Fatty Acids, Monounsaturated - administration & dosage</topic><topic>Fish Oils - chemistry</topic><topic>Food industries</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Insulin Resistance</topic><topic>Lipid A - blood</topic><topic>Male</topic><topic>Metabolic Syndrome - prevention & control</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Molecular Nutrition</topic><topic>Obesity - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Zhi-Hong</creatorcontrib><creatorcontrib>Miyahara, Hiroko</creatorcontrib><creatorcontrib>Mori, Tetsu</creatorcontrib><creatorcontrib>Doisaki, Nobushige</creatorcontrib><creatorcontrib>Hatanaka, Akimasa</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Zhi-Hong</au><au>Miyahara, Hiroko</au><au>Mori, Tetsu</au><au>Doisaki, Nobushige</au><au>Hatanaka, Akimasa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Beneficial Effects of Dietary Fish-Oil-Derived Monounsaturated Fatty Acids on Metabolic Syndrome Risk Factors and Insulin Resistance in Mice</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2011-07-13</date><risdate>2011</risdate><volume>59</volume><issue>13</issue><spage>7482</spage><epage>7489</epage><pages>7482-7489</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><coden>JAFCAU</coden><abstract>The aim of this study was to elucidate the effect of fish-oil-derived monounsaturated fatty acids (MUFAs) containing large amounts of C20:1 and C22:1 isomers on metabolic disorders in mice. Male C57BL/6J mice were fed a 32% lard diet (control) or a 27% lard plus 5% saury-oil-derived MUFA diet for 6 weeks. Dietary MUFA improved insulin resistance and alleviated metabolic syndrome risk factors by reducing blood glucose and lipids. These favorable changes may be attributed to an improved adipocytokine profile. MUFA ingestion resulted in favorable changes in mRNA expression of genes involved in glucose/lipid metabolism (SCD-1, CPT1a, UCPs, and CS) as well as inflammation (MAC1, MMP3, and SAA3) and alterations in fatty acid composition. Our data suggest that marine MUFA improved glucose/lipid homeostasis and hindered the development of metabolic syndrome in obese mice.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>21627145</pmid><doi>10.1021/jf201496h</doi><tpages>8</tpages></addata></record> |
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| source | ACS Publications; MEDLINE |
| subjects | Animals Biological and medical sciences Blood Glucose - analysis Dietary Fats - administration & dosage Dietary Fats, Unsaturated - administration & dosage Fat industries Fatty Acids, Monounsaturated - administration & dosage Fish Oils - chemistry Food industries Fundamental and applied biological sciences. Psychology Insulin Resistance Lipid A - blood Male Metabolic Syndrome - prevention & control Mice Mice, Inbred C57BL Molecular Nutrition Obesity - complications |
| title | Beneficial Effects of Dietary Fish-Oil-Derived Monounsaturated Fatty Acids on Metabolic Syndrome Risk Factors and Insulin Resistance in Mice |
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