Development of a high-performance liquid chromatography method for simultaneous determination of pioglitazone and felodipine in pig serum: application to pharmacokinetic study

A simple and sensitive high‐performance liquid chromatographic method was developed and validated for simultaneous estimation of pioglitazone and felodipine in pig serum. The present method consists of protein precipitation, extraction of analytes from pig serum into dichloromethane and separation u...

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Veröffentlicht in:	Biomedical chromatography 2011-08, Vol.25 (8), p.952-958
Hauptverfasser:	Palem, Chinna Reddy, Gannu, Ramesh, Yamsani, Shravan Kumar, Yamsani, Vamshi Vishnu, Yamsani, Madhusudan Rao
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Buccal Animals Area Under Curve Chromatography, High Pressure Liquid - methods Dosage Forms Drug Stability felodipine Felodipine - administration & dosage Felodipine - blood Felodipine - pharmacokinetics Linear Models pharmacokinetics pig serum pioglitazone Reproducibility of Results reversed-phase high-performance liquid chromatography Swine Thiazolidinediones - administration & dosage Thiazolidinediones - blood Thiazolidinediones - pharmacokinetics
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