Association between the presence of brown adipose tissue and non‐alcoholic fatty liver disease in adult humans

Aliment Pharmacol Ther 2011; 34: 318–323 Summary Background The presence of active brown adipose tissue (BAT) has been associated with a reduced risk of obesity in adult humans. Aim To examine whether the presence and activity of BAT in patients undergoing PET‐CT examinations is related to the presence of fatty liver. Method We retrospectively analysed 3666 consecutive PET‐CT whole‐body scans performed on a total of 1832 patients who were referred for suspected malignancies. BAT‐positive subjects (BAT+) were defined as subjects who showed substantial amounts of brown adipose tissue on PET‐CT scans. In areas where uptake of [18F]FDG was identified by CT for BAT, the maximal standardised uptake values (SUVmax), defined as the maximum activity per millilitre within the region of interest divided by the injected dose in megabecquerels per gram of body weight, were determined. A ratio of mean liver attenuation to spleen attenuation