Differential effects of amisulpride and haloperidol on dopamine D2 receptor-mediated signaling in SH-SY5Y cells

Dopamine D(2) receptors (D(2)R) are the primary target of antipsychotic drugs and have been shown to regulate Akt/glycogen synthase kinase-3β (GSK-3β) signaling through scaffolding protein β-arrestin 2. Amisulpride, an atypical antipsychotic drug, and haloperidol, a typical antipsychotic drug, are b...

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Veröffentlicht in:	Neuropharmacology 2011-09, Vol.61 (4), p.761-769
Hauptverfasser:	Park, Sung Woo, Seo, Mi Kyoung, Cho, Hye Yeon, Lee, Jung Goo, Lee, Bong Ju, Seol, Wongi, Kim, Young Hoon
Format:	Artikel
Sprache:	eng
Schlagworte:	Arrestins - physiology beta-Arrestin 2 beta-Arrestins Cell Line, Tumor Dopamine D2 Receptor Antagonists Haloperidol - pharmacology Humans Neurites - drug effects Neurites - physiology Receptors, Dopamine D2 - physiology Signal Transduction - drug effects Signal Transduction - physiology Sulpiride - analogs & derivatives Sulpiride - pharmacology
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