Ameliorative effect of caffeic acid against inflammatory pain in rodents

The present study was designed to evaluate the antinociceptive profile of caffeic acid in mice and rats. Caffeic acid (5–100 mg/kg, p.o.), in a dose dependent manner inhibited acetic acid-induced writhing and late phase of formalin-induced pain in mice, with an ED 50 of 22.38 and 10.92 mg/kg, respec...

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Veröffentlicht in:	European journal of pharmacology 2011-09, Vol.666 (1), p.80-86
Hauptverfasser:	Mehrotra, Anurag, Shanbhag, Ravindranath, Chamallamudi, Mallikarjuna Rao, Singh, Vijay Pal, Mudgal, Jayesh
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - adverse effects analgesic effect Animals Behavior, Animal - drug effects Biological and medical sciences Caffeic acid Caffeic Acids - pharmacology Caffeic Acids - therapeutic use carrageenan Carrageenan - adverse effects colorimetry Formaldehyde - adverse effects Inflammation - chemically induced Inflammation - complications Inflammatory pain lipopolysaccharides Lipopolysaccharides - adverse effects Male Malondialdehyde Malondialdehyde - metabolism Medical sciences Mice Myeloperoxidase Nitrite Nitrites - metabolism oral administration pain Pain - complications Pain - drug therapy Pain - metabolism Pain - pathology Peroxidase - metabolism Pharmacology. Drug treatments Rats tail
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