Systemic blood pressure profile correlates with cardiac 123I-MIBG uptake in patients with Parkinson's disease

To examine the correlation between the systemic blood pressure profile and cardiac 123I-metaiodobenzylguanidine (MIBG) uptake in patients with Parkinson's disease (PD), we monitored circadian blood pressure patterns of 37 PD patients of 49 to 85years of age (mean, 71.8±8.4years) using a portabl...

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Veröffentlicht in:Journal of the neurological sciences 2011-08, Vol.307 (1-2), p.153-156
Hauptverfasser: Manabe, Yasuhiro, Fujii, Daiki, Kono, Syoichiro, Sakai, Yasuko, Tanaka, Tomotaka, Narai, Hisashi, Omori, Nobuhiko, Imai, Yutaka, Abe, Koji
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container_end_page 156
container_issue 1-2
container_start_page 153
container_title Journal of the neurological sciences
container_volume 307
creator Manabe, Yasuhiro
Fujii, Daiki
Kono, Syoichiro
Sakai, Yasuko
Tanaka, Tomotaka
Narai, Hisashi
Omori, Nobuhiko
Imai, Yutaka
Abe, Koji
description To examine the correlation between the systemic blood pressure profile and cardiac 123I-metaiodobenzylguanidine (MIBG) uptake in patients with Parkinson's disease (PD), we monitored circadian blood pressure patterns of 37 PD patients of 49 to 85years of age (mean, 71.8±8.4years) using a portable blood pressure monitoring device. The duration of PD was 0.5 to 15years, and the disability level (modified Hoehn and Yahr stage) ranged from 1.0 to 4.0 (mean, 2.7±0.7). There were 37 age- and sex-matched control subjects. Cardiac MIBG scintigraphy was performed for the 37 PD patients. Based on the nocturnal fall in mean arterial blood pressure (MABP), we classified patients into extreme dippers (nocturnal reduction of MABP >20%), dippers (>10% but
doi_str_mv 10.1016/j.jns.2011.04.017
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The duration of PD was 0.5 to 15years, and the disability level (modified Hoehn and Yahr stage) ranged from 1.0 to 4.0 (mean, 2.7±0.7). There were 37 age- and sex-matched control subjects. Cardiac MIBG scintigraphy was performed for the 37 PD patients. Based on the nocturnal fall in mean arterial blood pressure (MABP), we classified patients into extreme dippers (nocturnal reduction of MABP >20%), dippers (>10% but <20%), nondippers (<10% but >0%), and inverted dippers (<0%). Average 24-hour MABP values revealed reduced BP variability in PD patients. The percentage nocturnal fall in MABP was significantly different between PD patients and control subjects (p<0.05). Significant correlations were found between % MABP reduction and the heart-to-mediastinum (H/M) ratio on early and delayed images (p<0.01). The UPDR motor score, early and delay H/M ratios were also significantly different between patients who were and were not dippers (p<0.05). The present results reported for the first time a significant correlation between the systemic blood pressure profile and cardiac 123I-MIBG uptake in patients with PD. The degeneration between the brainstem and the postganglionic neurons of myocardial sympathetic nerves may progress in parallel in patients with PD.]]></description><identifier>ISSN: 0022-510X</identifier><identifier>EISSN: 1878-5883</identifier><identifier>DOI: 10.1016/j.jns.2011.04.017</identifier><identifier>PMID: 21640359</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>123I-metaiodobenzylguanidine uptake ; 3-Iodobenzylguanidine ; Aged ; Aged, 80 and over ; Ambulatory blood pressure monitoring ; Autonomic Nervous System Diseases - diagnostic imaging ; Autonomic Nervous System Diseases - etiology ; Autonomic Nervous System Diseases - physiopathology ; Blood Pressure Determination ; Chronobiology Disorders - diagnostic imaging ; Chronobiology Disorders - etiology ; Chronobiology Disorders - physiopathology ; Female ; Humans ; Male ; Middle Aged ; Myocardial Perfusion Imaging - methods ; Parkinson Disease - complications ; Parkinson Disease - diagnostic imaging ; Parkinson Disease - physiopathology ; Parkinson's disease ; Radiopharmaceuticals</subject><ispartof>Journal of the neurological sciences, 2011-08, Vol.307 (1-2), p.153-156</ispartof><rights>2011 Elsevier B.V.</rights><rights>Copyright © 2011 Elsevier B.V. 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The present results reported for the first time a significant correlation between the systemic blood pressure profile and cardiac 123I-MIBG uptake in patients with PD. The degeneration between the brainstem and the postganglionic neurons of myocardial sympathetic nerves may progress in parallel in patients with PD.]]></description><subject>123I-metaiodobenzylguanidine uptake</subject><subject>3-Iodobenzylguanidine</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Ambulatory blood pressure monitoring</subject><subject>Autonomic Nervous System Diseases - diagnostic imaging</subject><subject>Autonomic Nervous System Diseases - etiology</subject><subject>Autonomic Nervous System Diseases - physiopathology</subject><subject>Blood Pressure Determination</subject><subject>Chronobiology Disorders - diagnostic imaging</subject><subject>Chronobiology Disorders - etiology</subject><subject>Chronobiology Disorders - physiopathology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial Perfusion Imaging - methods</subject><subject>Parkinson Disease - complications</subject><subject>Parkinson Disease - diagnostic imaging</subject><subject>Parkinson Disease - physiopathology</subject><subject>Parkinson's disease</subject><subject>Radiopharmaceuticals</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1P3DAQhq2qqCzQH8AF-cYpqcd2EkecKGphJRCVyoGb5dgT4SUfiydpxb9v6G575DRzeN5XMw9jpyByEFB-2eSbgXIpAHKhcwHVB7YCU5msMEZ9ZCshpMwKEI-H7IhoI4Qojak_sUMJpRaqqFes__lKE_bR86Ybx8C3CYnmhMsytrFD7seUsHMTEv8dpyfuXQrReQ5SrbO79ddrPm8n94w8DnzrpojDtCd_uPQcBxqHc-IhEjrCE3bQuo7w834es4fv3x6ubrLb--v11eVt5qGu6qzAIrQoWw2laprlzrJqlELROheaAKBrDLrUoIpGSOWcrBClVm2DGFApdczOd7XLEy8z0mT7SB67zg04zmRNpU1tDFQLCTvSp5EoYWu3KfYuvVoQ9s2x3djFsX1zbIW24m_mbN8-Nz2G_4l_UhfgYgfg8uKviMmSX7x4DDGhn2wY4zv1fwC_HI3r</recordid><startdate>20110815</startdate><enddate>20110815</enddate><creator>Manabe, Yasuhiro</creator><creator>Fujii, Daiki</creator><creator>Kono, Syoichiro</creator><creator>Sakai, Yasuko</creator><creator>Tanaka, Tomotaka</creator><creator>Narai, Hisashi</creator><creator>Omori, Nobuhiko</creator><creator>Imai, Yutaka</creator><creator>Abe, Koji</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110815</creationdate><title>Systemic blood pressure profile correlates with cardiac 123I-MIBG uptake in patients with Parkinson's disease</title><author>Manabe, Yasuhiro ; 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The present results reported for the first time a significant correlation between the systemic blood pressure profile and cardiac 123I-MIBG uptake in patients with PD. The degeneration between the brainstem and the postganglionic neurons of myocardial sympathetic nerves may progress in parallel in patients with PD.]]></abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>21640359</pmid><doi>10.1016/j.jns.2011.04.017</doi><tpages>4</tpages></addata></record>
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subjects 123I-metaiodobenzylguanidine uptake
3-Iodobenzylguanidine
Aged
Aged, 80 and over
Ambulatory blood pressure monitoring
Autonomic Nervous System Diseases - diagnostic imaging
Autonomic Nervous System Diseases - etiology
Autonomic Nervous System Diseases - physiopathology
Blood Pressure Determination
Chronobiology Disorders - diagnostic imaging
Chronobiology Disorders - etiology
Chronobiology Disorders - physiopathology
Female
Humans
Male
Middle Aged
Myocardial Perfusion Imaging - methods
Parkinson Disease - complications
Parkinson Disease - diagnostic imaging
Parkinson Disease - physiopathology
Parkinson's disease
Radiopharmaceuticals
title Systemic blood pressure profile correlates with cardiac 123I-MIBG uptake in patients with Parkinson's disease
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