Systemic blood pressure profile correlates with cardiac 123I-MIBG uptake in patients with Parkinson's disease
To examine the correlation between the systemic blood pressure profile and cardiac 123I-metaiodobenzylguanidine (MIBG) uptake in patients with Parkinson's disease (PD), we monitored circadian blood pressure patterns of 37 PD patients of 49 to 85years of age (mean, 71.8±8.4years) using a portabl...
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description | To examine the correlation between the systemic blood pressure profile and cardiac 123I-metaiodobenzylguanidine (MIBG) uptake in patients with Parkinson's disease (PD), we monitored circadian blood pressure patterns of 37 PD patients of 49 to 85years of age (mean, 71.8±8.4years) using a portable blood pressure monitoring device. The duration of PD was 0.5 to 15years, and the disability level (modified Hoehn and Yahr stage) ranged from 1.0 to 4.0 (mean, 2.7±0.7). There were 37 age- and sex-matched control subjects. Cardiac MIBG scintigraphy was performed for the 37 PD patients. Based on the nocturnal fall in mean arterial blood pressure (MABP), we classified patients into extreme dippers (nocturnal reduction of MABP >20%), dippers (>10% but |
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The duration of PD was 0.5 to 15years, and the disability level (modified Hoehn and Yahr stage) ranged from 1.0 to 4.0 (mean, 2.7±0.7). There were 37 age- and sex-matched control subjects. Cardiac MIBG scintigraphy was performed for the 37 PD patients. Based on the nocturnal fall in mean arterial blood pressure (MABP), we classified patients into extreme dippers (nocturnal reduction of MABP >20%), dippers (>10% but <20%), nondippers (<10% but >0%), and inverted dippers (<0%). Average 24-hour MABP values revealed reduced BP variability in PD patients. The percentage nocturnal fall in MABP was significantly different between PD patients and control subjects (p<0.05). Significant correlations were found between % MABP reduction and the heart-to-mediastinum (H/M) ratio on early and delayed images (p<0.01). The UPDR motor score, early and delay H/M ratios were also significantly different between patients who were and were not dippers (p<0.05). The present results reported for the first time a significant correlation between the systemic blood pressure profile and cardiac 123I-MIBG uptake in patients with PD. The degeneration between the brainstem and the postganglionic neurons of myocardial sympathetic nerves may progress in parallel in patients with PD.]]></description><identifier>ISSN: 0022-510X</identifier><identifier>EISSN: 1878-5883</identifier><identifier>DOI: 10.1016/j.jns.2011.04.017</identifier><identifier>PMID: 21640359</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>123I-metaiodobenzylguanidine uptake ; 3-Iodobenzylguanidine ; Aged ; Aged, 80 and over ; Ambulatory blood pressure monitoring ; Autonomic Nervous System Diseases - diagnostic imaging ; Autonomic Nervous System Diseases - etiology ; Autonomic Nervous System Diseases - physiopathology ; Blood Pressure Determination ; Chronobiology Disorders - diagnostic imaging ; Chronobiology Disorders - etiology ; Chronobiology Disorders - physiopathology ; Female ; Humans ; Male ; Middle Aged ; Myocardial Perfusion Imaging - methods ; Parkinson Disease - complications ; Parkinson Disease - diagnostic imaging ; Parkinson Disease - physiopathology ; Parkinson's disease ; Radiopharmaceuticals</subject><ispartof>Journal of the neurological sciences, 2011-08, Vol.307 (1-2), p.153-156</ispartof><rights>2011 Elsevier B.V.</rights><rights>Copyright © 2011 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1979-5e5dfe2f4163bb35967b33e0faadbd1149ed464135b023aa27ee243fbeede333</citedby><cites>FETCH-LOGICAL-c1979-5e5dfe2f4163bb35967b33e0faadbd1149ed464135b023aa27ee243fbeede333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jns.2011.04.017$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21640359$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Manabe, Yasuhiro</creatorcontrib><creatorcontrib>Fujii, Daiki</creatorcontrib><creatorcontrib>Kono, Syoichiro</creatorcontrib><creatorcontrib>Sakai, Yasuko</creatorcontrib><creatorcontrib>Tanaka, Tomotaka</creatorcontrib><creatorcontrib>Narai, Hisashi</creatorcontrib><creatorcontrib>Omori, Nobuhiko</creatorcontrib><creatorcontrib>Imai, Yutaka</creatorcontrib><creatorcontrib>Abe, Koji</creatorcontrib><title>Systemic blood pressure profile correlates with cardiac 123I-MIBG uptake in patients with Parkinson's disease</title><title>Journal of the neurological sciences</title><addtitle>J Neurol Sci</addtitle><description><![CDATA[To examine the correlation between the systemic blood pressure profile and cardiac 123I-metaiodobenzylguanidine (MIBG) uptake in patients with Parkinson's disease (PD), we monitored circadian blood pressure patterns of 37 PD patients of 49 to 85years of age (mean, 71.8±8.4years) using a portable blood pressure monitoring device. The duration of PD was 0.5 to 15years, and the disability level (modified Hoehn and Yahr stage) ranged from 1.0 to 4.0 (mean, 2.7±0.7). There were 37 age- and sex-matched control subjects. Cardiac MIBG scintigraphy was performed for the 37 PD patients. Based on the nocturnal fall in mean arterial blood pressure (MABP), we classified patients into extreme dippers (nocturnal reduction of MABP >20%), dippers (>10% but <20%), nondippers (<10% but >0%), and inverted dippers (<0%). Average 24-hour MABP values revealed reduced BP variability in PD patients. The percentage nocturnal fall in MABP was significantly different between PD patients and control subjects (p<0.05). Significant correlations were found between % MABP reduction and the heart-to-mediastinum (H/M) ratio on early and delayed images (p<0.01). The UPDR motor score, early and delay H/M ratios were also significantly different between patients who were and were not dippers (p<0.05). The present results reported for the first time a significant correlation between the systemic blood pressure profile and cardiac 123I-MIBG uptake in patients with PD. The degeneration between the brainstem and the postganglionic neurons of myocardial sympathetic nerves may progress in parallel in patients with PD.]]></description><subject>123I-metaiodobenzylguanidine uptake</subject><subject>3-Iodobenzylguanidine</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Ambulatory blood pressure monitoring</subject><subject>Autonomic Nervous System Diseases - diagnostic imaging</subject><subject>Autonomic Nervous System Diseases - etiology</subject><subject>Autonomic Nervous System Diseases - physiopathology</subject><subject>Blood Pressure Determination</subject><subject>Chronobiology Disorders - diagnostic imaging</subject><subject>Chronobiology Disorders - etiology</subject><subject>Chronobiology Disorders - physiopathology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial Perfusion Imaging - methods</subject><subject>Parkinson Disease - complications</subject><subject>Parkinson Disease - diagnostic imaging</subject><subject>Parkinson Disease - physiopathology</subject><subject>Parkinson's disease</subject><subject>Radiopharmaceuticals</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1P3DAQhq2qqCzQH8AF-cYpqcd2EkecKGphJRCVyoGb5dgT4SUfiydpxb9v6G575DRzeN5XMw9jpyByEFB-2eSbgXIpAHKhcwHVB7YCU5msMEZ9ZCshpMwKEI-H7IhoI4Qojak_sUMJpRaqqFes__lKE_bR86Ybx8C3CYnmhMsytrFD7seUsHMTEv8dpyfuXQrReQ5SrbO79ddrPm8n94w8DnzrpojDtCd_uPQcBxqHc-IhEjrCE3bQuo7w834es4fv3x6ubrLb--v11eVt5qGu6qzAIrQoWw2laprlzrJqlELROheaAKBrDLrUoIpGSOWcrBClVm2DGFApdczOd7XLEy8z0mT7SB67zg04zmRNpU1tDFQLCTvSp5EoYWu3KfYuvVoQ9s2x3djFsX1zbIW24m_mbN8-Nz2G_4l_UhfgYgfg8uKviMmSX7x4DDGhn2wY4zv1fwC_HI3r</recordid><startdate>20110815</startdate><enddate>20110815</enddate><creator>Manabe, Yasuhiro</creator><creator>Fujii, Daiki</creator><creator>Kono, Syoichiro</creator><creator>Sakai, Yasuko</creator><creator>Tanaka, Tomotaka</creator><creator>Narai, Hisashi</creator><creator>Omori, Nobuhiko</creator><creator>Imai, Yutaka</creator><creator>Abe, Koji</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110815</creationdate><title>Systemic blood pressure profile correlates with cardiac 123I-MIBG uptake in patients with Parkinson's disease</title><author>Manabe, Yasuhiro ; Fujii, Daiki ; Kono, Syoichiro ; Sakai, Yasuko ; Tanaka, Tomotaka ; Narai, Hisashi ; Omori, Nobuhiko ; Imai, Yutaka ; Abe, Koji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1979-5e5dfe2f4163bb35967b33e0faadbd1149ed464135b023aa27ee243fbeede333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>123I-metaiodobenzylguanidine uptake</topic><topic>3-Iodobenzylguanidine</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Ambulatory blood pressure monitoring</topic><topic>Autonomic Nervous System Diseases - diagnostic imaging</topic><topic>Autonomic Nervous System Diseases - etiology</topic><topic>Autonomic Nervous System Diseases - physiopathology</topic><topic>Blood Pressure Determination</topic><topic>Chronobiology Disorders - diagnostic imaging</topic><topic>Chronobiology Disorders - etiology</topic><topic>Chronobiology Disorders - physiopathology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardial Perfusion Imaging - methods</topic><topic>Parkinson Disease - complications</topic><topic>Parkinson Disease - diagnostic imaging</topic><topic>Parkinson Disease - physiopathology</topic><topic>Parkinson's disease</topic><topic>Radiopharmaceuticals</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Manabe, Yasuhiro</creatorcontrib><creatorcontrib>Fujii, Daiki</creatorcontrib><creatorcontrib>Kono, Syoichiro</creatorcontrib><creatorcontrib>Sakai, Yasuko</creatorcontrib><creatorcontrib>Tanaka, Tomotaka</creatorcontrib><creatorcontrib>Narai, Hisashi</creatorcontrib><creatorcontrib>Omori, Nobuhiko</creatorcontrib><creatorcontrib>Imai, Yutaka</creatorcontrib><creatorcontrib>Abe, Koji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Manabe, Yasuhiro</au><au>Fujii, Daiki</au><au>Kono, Syoichiro</au><au>Sakai, Yasuko</au><au>Tanaka, Tomotaka</au><au>Narai, Hisashi</au><au>Omori, Nobuhiko</au><au>Imai, Yutaka</au><au>Abe, Koji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Systemic blood pressure profile correlates with cardiac 123I-MIBG uptake in patients with Parkinson's disease</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>2011-08-15</date><risdate>2011</risdate><volume>307</volume><issue>1-2</issue><spage>153</spage><epage>156</epage><pages>153-156</pages><issn>0022-510X</issn><eissn>1878-5883</eissn><abstract><![CDATA[To examine the correlation between the systemic blood pressure profile and cardiac 123I-metaiodobenzylguanidine (MIBG) uptake in patients with Parkinson's disease (PD), we monitored circadian blood pressure patterns of 37 PD patients of 49 to 85years of age (mean, 71.8±8.4years) using a portable blood pressure monitoring device. The duration of PD was 0.5 to 15years, and the disability level (modified Hoehn and Yahr stage) ranged from 1.0 to 4.0 (mean, 2.7±0.7). There were 37 age- and sex-matched control subjects. Cardiac MIBG scintigraphy was performed for the 37 PD patients. Based on the nocturnal fall in mean arterial blood pressure (MABP), we classified patients into extreme dippers (nocturnal reduction of MABP >20%), dippers (>10% but <20%), nondippers (<10% but >0%), and inverted dippers (<0%). Average 24-hour MABP values revealed reduced BP variability in PD patients. The percentage nocturnal fall in MABP was significantly different between PD patients and control subjects (p<0.05). Significant correlations were found between % MABP reduction and the heart-to-mediastinum (H/M) ratio on early and delayed images (p<0.01). The UPDR motor score, early and delay H/M ratios were also significantly different between patients who were and were not dippers (p<0.05). The present results reported for the first time a significant correlation between the systemic blood pressure profile and cardiac 123I-MIBG uptake in patients with PD. The degeneration between the brainstem and the postganglionic neurons of myocardial sympathetic nerves may progress in parallel in patients with PD.]]></abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>21640359</pmid><doi>10.1016/j.jns.2011.04.017</doi><tpages>4</tpages></addata></record> |
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subjects | 123I-metaiodobenzylguanidine uptake 3-Iodobenzylguanidine Aged Aged, 80 and over Ambulatory blood pressure monitoring Autonomic Nervous System Diseases - diagnostic imaging Autonomic Nervous System Diseases - etiology Autonomic Nervous System Diseases - physiopathology Blood Pressure Determination Chronobiology Disorders - diagnostic imaging Chronobiology Disorders - etiology Chronobiology Disorders - physiopathology Female Humans Male Middle Aged Myocardial Perfusion Imaging - methods Parkinson Disease - complications Parkinson Disease - diagnostic imaging Parkinson Disease - physiopathology Parkinson's disease Radiopharmaceuticals |
title | Systemic blood pressure profile correlates with cardiac 123I-MIBG uptake in patients with Parkinson's disease |
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