Plastid expression of a double-pentameric vaccine candidate containing human papillomavirus-16 L1 antigen fused with LTB as adjuvant: transplastomic plants show pleiotropic phenotypes

Summary Human papillomavirus (HPV) causes cervical cancer in women worldwide, which is currently prevented by vaccines based on virus‐like particles (VLPs). However, these vaccines have certain limitations in their availability to developing countries, largely due to elevated costs. Concerning the h...

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Veröffentlicht in:	Plant biotechnology journal 2011-08, Vol.9 (6), p.651-660
Hauptverfasser:	Waheed, Mohammad T., Thönes, Nadja, Müller, Martin, Hassan, Syed W., Gottschamel, Johanna, Lössl, Elke, Kaul, Hans-Peter, Lössl, Andreas G.
Format:	Artikel
Sprache:	eng
Schlagworte:	adjuvant Adjuvants, Immunologic - genetics Antigens, Viral - genetics Bacterial Toxins - chemistry Bacterial Toxins - genetics Bacterial Toxins - metabolism Capsid Proteins - chemistry Capsid Proteins - genetics Capsid Proteins - immunology capsomeres Chloroplasts - genetics Chloroplasts - metabolism Enterotoxins - chemistry Enterotoxins - genetics Enterotoxins - metabolism Epitopes Escherichia coli Proteins - chemistry Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Female G(M1) Ganglioside - metabolism HPV-16 L1 Humans low-cost vaccine LTB Nicotiana - genetics Nicotiana - growth & development Nicotiana - metabolism Oncogene Proteins, Viral - chemistry Oncogene Proteins, Viral - genetics Oncogene Proteins, Viral - immunology Papillomavirus Vaccines - genetics Papillomavirus Vaccines - immunology Papillomavirus Vaccines - metabolism Phenotype Plant Infertility - genetics Plants, Genetically Modified - genetics plastid transformation Plastids - genetics Pollination Protein Conformation Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - immunology Recombinant Fusion Proteins - metabolism Seeds - physiology Uterine Cervical Neoplasms - immunology
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