Differentiated Human Colorectal Cancer Cells Protect Tumor-Initiating Cells From Irinotecan

Background & Aims Stem cells of normal tissues have resistance mechanisms that allow them to survive genotoxic insults. The stem cell–like cells of tumors are defined by their tumor-initiating capacity and may have retained these resistance mechanisms, making them resistant to chemotherapy. We s...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2011-07, Vol.141 (1), p.269-278
Hauptverfasser:	Emmink, Benjamin L, Van Houdt, Winan J, Vries, Robert G, Hoogwater, Frederik J.H, Govaert, Klaas M, Verheem, Andre, Nijkamp, Maarten W, Steller, Ernst J.A, Jimenez, Connie R, Clevers, Hans, Borel Rinkes, Inne H.M, Kranenburg, Onno
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - metabolism Adenocarcinoma - secondary Aldehyde Dehydrogenase - metabolism Animals Antineoplastic Agents, Phytogenic - metabolism Antineoplastic Agents, Phytogenic - pharmacology ATP Binding Cassette Transporter, Sub-Family B ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Biomarkers, Tumor - metabolism Blotting, Western Camptothecin - analogs & derivatives Camptothecin - metabolism Camptothecin - pharmacology Cancer Stem Cell Cell Differentiation - drug effects Colon Cancer Colonic Neoplasms - drug therapy Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Cyclosporins - pharmacology Dose-Response Relationship, Drug Drug Resistance Drug Resistance, Neoplasm - drug effects Flow Cytometry - methods Gastroenterology and Hepatology Humans Liver Neoplasms - drug therapy Liver Neoplasms - metabolism Liver Neoplasms - secondary Metastasis Mice Mice, Inbred BALB C Mice, Nude Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Spheroids, Cellular Time Factors Topoisomerase I Inhibitors - metabolism Topoisomerase I Inhibitors - pharmacology Tumor Burden - drug effects Tumor Cells, Cultured Tumor Progression Xenograft Model Antitumor Assays
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