Trans-sialidase and mucins of Trypanosoma cruzi: an important interplay for the parasite

A dense glycocalix covers the surface of Trypanosoma cruzi, the agent of Chagas disease. Sialic acid in the surface of the parasite plays an important role in the infectious process, however, T. cruzi is unable to synthesize sialic acid or the usual donor CMP-sialic acid. Instead, T. cruzi expresses...

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Veröffentlicht in:	Carbohydrate research 2011-09, Vol.346 (12), p.1389-1393
Hauptverfasser:	Eugenia Giorgi, M., de Lederkremer, Rosa M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals blood flow Carbohydrate Sequence Chagas disease Chagas Disease - metabolism Chagas Disease - parasitology Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use epimastigotes Glycoconjugates - chemistry Glycoconjugates - metabolism Glycoproteins - antagonists & inhibitors Glycoproteins - metabolism Glycosylphosphatidylinositols - metabolism Humans immune system insects Life Cycle Stages mammals Molecular Sequence Data Mucins Mucins - chemistry Mucins - metabolism Neuraminidase - antagonists & inhibitors Neuraminidase - metabolism parasites plasma membrane Protein Binding sialic acids Sialic Acids - metabolism Species Specificity Trans-sialidase Trypanosoma cruzi Trypanosoma cruzi - enzymology trypomastigotes Type C Phospholipases - metabolism
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