Ovarian preservation in a young patient with Gorlin syndrome and multiple bilateral ovarian masses
Objective To report a case of bilateral ovarian fibromas and ovarian leiomyomas in a young patient with Gorlin syndrome and to highlight issues of fertility preservation, ovarian conservation, and preimplantation genetic diagnosis in this population. Design Case report. Setting University hospital....
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| Veröffentlicht in: | Fertility and sterility 2011-07, Vol.96 (1), p.e47-e50 |
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| creator | Morse, Christopher B., B.A McLaren, Janet F., M.D Roy, Darshan, M.D Siegelman, Evan S., M.D LiVolsi, Virginia A., M.D Gracia, Clarisa R., M.D., M.S.C.E |
| description | Objective To report a case of bilateral ovarian fibromas and ovarian leiomyomas in a young patient with Gorlin syndrome and to highlight issues of fertility preservation, ovarian conservation, and preimplantation genetic diagnosis in this population. Design Case report. Setting University hospital. Patient(s) A 15-year-old female patient with Gorlin syndrome and bilateral ovarian masses. Intervention(s) Ultrasound, magnetic resonance imaging, hormone analysis, and laparotomy with resection of ovarian fibromas. Main Outcome Measure(s) Preservation of ovarian function, pathologic diagnosis. Result(s) Our patient represented an adolescent case of bilateral ovarian fibromas and leiomyomas in Gorlin syndrome presenting with menstrual irregularities. She was managed surgically with resection of the lesions and conservation of normal ovarian tissue. Conclusion(s) In Gorlin syndrome, ovarian fibromas are a common clinical manifestation. Patients with ovarian involvement may present with complex gynecologic needs and may have decreased fertility potential. Careful surgical management, follow-up, and counseling on options for future fertility should be offered to all patients. |
| doi_str_mv | 10.1016/j.fertnstert.2011.04.028 |
| format | Article |
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Design Case report. Setting University hospital. Patient(s) A 15-year-old female patient with Gorlin syndrome and bilateral ovarian masses. Intervention(s) Ultrasound, magnetic resonance imaging, hormone analysis, and laparotomy with resection of ovarian fibromas. Main Outcome Measure(s) Preservation of ovarian function, pathologic diagnosis. Result(s) Our patient represented an adolescent case of bilateral ovarian fibromas and leiomyomas in Gorlin syndrome presenting with menstrual irregularities. She was managed surgically with resection of the lesions and conservation of normal ovarian tissue. Conclusion(s) In Gorlin syndrome, ovarian fibromas are a common clinical manifestation. Patients with ovarian involvement may present with complex gynecologic needs and may have decreased fertility potential. Careful surgical management, follow-up, and counseling on options for future fertility should be offered to all patients.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/j.fertnstert.2011.04.028</identifier><identifier>PMID: 21565340</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; adolescents ; animal ovaries ; Basal Cell Nevus Syndrome - complications ; Basal Cell Nevus Syndrome - diagnostic imaging ; Basal Cell Nevus Syndrome - surgery ; case studies ; counseling ; Female ; fertility preservation ; Gorlin syndrome ; Humans ; Internal Medicine ; laparotomy ; Leiomyoma - complications ; Leiomyoma - diagnostic imaging ; Leiomyoma - surgery ; magnetic resonance imaging ; nevoid basal cell carcinoma syndrome ; Obstetrics and Gynecology ; ovarian conservation ; Ovarian Neoplasms - complications ; Ovarian Neoplasms - diagnostic imaging ; Ovarian Neoplasms - surgery ; Ovary - diagnostic imaging ; Ovary - surgery ; patients ; preimplantation genetic diagnosis ; resection ; ultrasonics ; Ultrasonography ; Uterine Neoplasms - diagnostic imaging ; Uterine Neoplasms - surgery</subject><ispartof>Fertility and sterility, 2011-07, Vol.96 (1), p.e47-e50</ispartof><rights>American Society for Reproductive Medicine</rights><rights>2011 American Society for Reproductive Medicine</rights><rights>Copyright © 2011 American Society for Reproductive Medicine. 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Design Case report. Setting University hospital. Patient(s) A 15-year-old female patient with Gorlin syndrome and bilateral ovarian masses. Intervention(s) Ultrasound, magnetic resonance imaging, hormone analysis, and laparotomy with resection of ovarian fibromas. Main Outcome Measure(s) Preservation of ovarian function, pathologic diagnosis. Result(s) Our patient represented an adolescent case of bilateral ovarian fibromas and leiomyomas in Gorlin syndrome presenting with menstrual irregularities. She was managed surgically with resection of the lesions and conservation of normal ovarian tissue. Conclusion(s) In Gorlin syndrome, ovarian fibromas are a common clinical manifestation. Patients with ovarian involvement may present with complex gynecologic needs and may have decreased fertility potential. Careful surgical management, follow-up, and counseling on options for future fertility should be offered to all patients.</description><subject>Adolescent</subject><subject>adolescents</subject><subject>animal ovaries</subject><subject>Basal Cell Nevus Syndrome - complications</subject><subject>Basal Cell Nevus Syndrome - diagnostic imaging</subject><subject>Basal Cell Nevus Syndrome - surgery</subject><subject>case studies</subject><subject>counseling</subject><subject>Female</subject><subject>fertility preservation</subject><subject>Gorlin syndrome</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>laparotomy</subject><subject>Leiomyoma - complications</subject><subject>Leiomyoma - diagnostic imaging</subject><subject>Leiomyoma - surgery</subject><subject>magnetic resonance imaging</subject><subject>nevoid basal cell carcinoma syndrome</subject><subject>Obstetrics and Gynecology</subject><subject>ovarian conservation</subject><subject>Ovarian Neoplasms - complications</subject><subject>Ovarian Neoplasms - diagnostic imaging</subject><subject>Ovarian Neoplasms - surgery</subject><subject>Ovary - diagnostic imaging</subject><subject>Ovary - surgery</subject><subject>patients</subject><subject>preimplantation genetic diagnosis</subject><subject>resection</subject><subject>ultrasonics</subject><subject>Ultrasonography</subject><subject>Uterine Neoplasms - diagnostic imaging</subject><subject>Uterine Neoplasms - surgery</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkkGL1TAQgIMo7nP1L2hunlonaZM2F0EXXYWFPawL3kKaTNc826Ym7ZP37015TwVPXiaQfDMZvhlCKIOSAZNv9mWPcZnSkmPJgbES6hJ4-4jsmBCyEFJUj8kOgIkiX_ML8iylPQBI1vCn5IKzjahhR7rbg4neTHSOmDAezOLDRP1EDT2GdXqgc77BaaE__fKNXoc45Ld0nFwMI1IzOTquw-LnAWnnB5MbMgMN55qjSQnTc_KkN0PCF-fzktx__PDl6lNxc3v9-erdTWEF8KWQiAq6SjnoRS1UhyhsixwcCNY6ZjvFlQVZy1ZYlwOrZAPOuFbWTaNUV12S16e6cww_VkyLHn2yOAxmwrAm3TZ1qzLKM9meSBtDShF7PUc_mnjUDPQmWO_1X8F6E6yh1tlkTn15_mTtRnR_En8bzcCrE9CboM1D9Enf3-UKIg-DN0rWmXh_IjDLOHiMOtms2KLzEe2iXfD_08fbf4rYPBlvzfAdj5j2YY1Tlq2ZTlyDvttWYdsExvISVOpr9Qv7FrE4</recordid><startdate>20110701</startdate><enddate>20110701</enddate><creator>Morse, Christopher B., B.A</creator><creator>McLaren, Janet F., M.D</creator><creator>Roy, Darshan, M.D</creator><creator>Siegelman, Evan S., M.D</creator><creator>LiVolsi, Virginia A., M.D</creator><creator>Gracia, Clarisa R., M.D., M.S.C.E</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110701</creationdate><title>Ovarian preservation in a young patient with Gorlin syndrome and multiple bilateral ovarian masses</title><author>Morse, Christopher B., B.A ; McLaren, Janet F., M.D ; Roy, Darshan, M.D ; Siegelman, Evan S., M.D ; LiVolsi, Virginia A., M.D ; Gracia, Clarisa R., M.D., M.S.C.E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c502t-6ee90b39d0f5459bee5c8e20d0518d1cb929c064685cd68513670dad8647799b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>adolescents</topic><topic>animal ovaries</topic><topic>Basal Cell Nevus Syndrome - complications</topic><topic>Basal Cell Nevus Syndrome - diagnostic imaging</topic><topic>Basal Cell Nevus Syndrome - surgery</topic><topic>case studies</topic><topic>counseling</topic><topic>Female</topic><topic>fertility preservation</topic><topic>Gorlin syndrome</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>laparotomy</topic><topic>Leiomyoma - complications</topic><topic>Leiomyoma - diagnostic imaging</topic><topic>Leiomyoma - surgery</topic><topic>magnetic resonance imaging</topic><topic>nevoid basal cell carcinoma syndrome</topic><topic>Obstetrics and Gynecology</topic><topic>ovarian conservation</topic><topic>Ovarian Neoplasms - complications</topic><topic>Ovarian Neoplasms - diagnostic imaging</topic><topic>Ovarian Neoplasms - surgery</topic><topic>Ovary - diagnostic imaging</topic><topic>Ovary - surgery</topic><topic>patients</topic><topic>preimplantation genetic diagnosis</topic><topic>resection</topic><topic>ultrasonics</topic><topic>Ultrasonography</topic><topic>Uterine Neoplasms - diagnostic imaging</topic><topic>Uterine Neoplasms - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morse, Christopher B., B.A</creatorcontrib><creatorcontrib>McLaren, Janet F., M.D</creatorcontrib><creatorcontrib>Roy, Darshan, M.D</creatorcontrib><creatorcontrib>Siegelman, Evan S., M.D</creatorcontrib><creatorcontrib>LiVolsi, Virginia A., M.D</creatorcontrib><creatorcontrib>Gracia, Clarisa R., M.D., M.S.C.E</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morse, Christopher B., B.A</au><au>McLaren, Janet F., M.D</au><au>Roy, Darshan, M.D</au><au>Siegelman, Evan S., M.D</au><au>LiVolsi, Virginia A., M.D</au><au>Gracia, Clarisa R., M.D., M.S.C.E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ovarian preservation in a young patient with Gorlin syndrome and multiple bilateral ovarian masses</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>2011-07-01</date><risdate>2011</risdate><volume>96</volume><issue>1</issue><spage>e47</spage><epage>e50</epage><pages>e47-e50</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><abstract>Objective To report a case of bilateral ovarian fibromas and ovarian leiomyomas in a young patient with Gorlin syndrome and to highlight issues of fertility preservation, ovarian conservation, and preimplantation genetic diagnosis in this population. Design Case report. Setting University hospital. Patient(s) A 15-year-old female patient with Gorlin syndrome and bilateral ovarian masses. Intervention(s) Ultrasound, magnetic resonance imaging, hormone analysis, and laparotomy with resection of ovarian fibromas. Main Outcome Measure(s) Preservation of ovarian function, pathologic diagnosis. Result(s) Our patient represented an adolescent case of bilateral ovarian fibromas and leiomyomas in Gorlin syndrome presenting with menstrual irregularities. She was managed surgically with resection of the lesions and conservation of normal ovarian tissue. Conclusion(s) In Gorlin syndrome, ovarian fibromas are a common clinical manifestation. Patients with ovarian involvement may present with complex gynecologic needs and may have decreased fertility potential. 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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adolescent adolescents animal ovaries Basal Cell Nevus Syndrome - complications Basal Cell Nevus Syndrome - diagnostic imaging Basal Cell Nevus Syndrome - surgery case studies counseling Female fertility preservation Gorlin syndrome Humans Internal Medicine laparotomy Leiomyoma - complications Leiomyoma - diagnostic imaging Leiomyoma - surgery magnetic resonance imaging nevoid basal cell carcinoma syndrome Obstetrics and Gynecology ovarian conservation Ovarian Neoplasms - complications Ovarian Neoplasms - diagnostic imaging Ovarian Neoplasms - surgery Ovary - diagnostic imaging Ovary - surgery patients preimplantation genetic diagnosis resection ultrasonics Ultrasonography Uterine Neoplasms - diagnostic imaging Uterine Neoplasms - surgery |
| title | Ovarian preservation in a young patient with Gorlin syndrome and multiple bilateral ovarian masses |
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