Ischemic insult induced apoptotic changes in PC12 cells: Protection by trans resveratrol

In this study, we determined the protective potential of trans resveratrol against oxygen–glucose deprivation (OGD) induced reactive oxygen species mediated apoptotic damages in PC12 cells. In vitro model of ischemic cerebral stroke was created by keeping cells in an OGD condition for 6 h followed b...

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Veröffentlicht in:	European journal of pharmacology 2011-09, Vol.666 (1), p.5-11
Hauptverfasser:	Agrawal, Megha, Kumar, Vivek, Kashyap, Mahendra P., Khanna, Vinay K., Randhawa, Gursharn S., Pant, Aditya B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Apoptosis - genetics bcl-2-Associated X Protein - biosynthesis bcl-2-Associated X Protein - genetics Biological and medical sciences Brain Ischemia - genetics Brain Ischemia - metabolism Brain Ischemia - pathology Brain Ischemia - prevention & control Caspase 3 - biosynthesis Caspase 3 - genetics Glucose - metabolism Glutathione - metabolism Hypoxia-Inducible Factor 1, alpha Subunit - biosynthesis Hypoxia-Inducible Factor 1, alpha Subunit - genetics Lipid Peroxidation - drug effects Medical sciences Neurons - drug effects Neurons - metabolism Neurons - pathology Neuroprotection Neuroprotective Agents - pharmacology OGD Oxidative Stress - drug effects Oxidative Stress - genetics Oxygen - metabolism PC12 cell PC12 Cells Pharmacology. Drug treatments Proto-Oncogene Proteins c-bcl-2 - biosynthesis Proto-Oncogene Proteins c-bcl-2 - genetics Rats Reactive Oxygen Species - metabolism Stilbenes - pharmacology Trans resveratrol Transcription, Genetic - drug effects
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