Effect of thymol on peripheral blood mononuclear cell PBMC and acute promyelotic cancer cell line HL-60

► Thymol induces disruption of mitochondrial membrane potential, which is associated with apoptosis. ► Disruption of mitochondrial membrane and activation of apoptosis appears to be dependent on reactive oxygen species. ► Thymol treatment caused activation of caspase-9, -8 and -3 and concomitant PAR...

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Veröffentlicht in:	Chemico-biological interactions 2011-08, Vol.193 (1), p.97-106
Hauptverfasser:	Deb, Dipanwita Dutta, Parimala, G., Saravana Devi, S., Chakraborty, Tapan
Format:	Artikel
Sprache:	eng
Schlagworte:	anticarcinogenic activity antineoplastic agents Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use antioxidants Apoptosis Apoptosis - drug effects Apoptosis inducing factor Apoptosis Inducing Factor - metabolism bcl-2-Associated X Protein - metabolism Caspase 3 - metabolism Caspase 8 - metabolism Caspase 9 - metabolism Caspases cell cycle cytosol cytotoxicity DNA DNA fragmentation G1 Phase HL-60 Cells Humans hydrogen peroxide leukemia Leukemia, Promyelocytic, Acute - drug therapy Leukemia, Promyelocytic, Acute - metabolism Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism membrane potential Membrane Potential, Mitochondrial - drug effects mitochondria mitochondrial membrane Mitochondrial membrane potential mononuclear leukocytes protein synthesis Proto-Oncogene Proteins c-bcl-2 - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism Resting Phase, Cell Cycle Thymol Thymol - chemistry Thymol - pharmacology Thymol - therapeutic use Western blotting
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