Modelling the effect of venous disease on quality of life
Background: A clear understanding of the relationship between venous reflux, clinical venous disease and the effects on quality of life (QoL) remains elusive. This study aimed to explore the impact of venous disease, and assess any incremental direct effect of progressive disease on health‐related Q...
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| Veröffentlicht in: | British journal of surgery 2011-08, Vol.98 (8), p.1089-1098 |
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| creator | Carradice, D. Mazari, F. A. K. Samuel, N. Allgar, V. Hatfield, J. Chetter, I. C. |
| description | Background:
A clear understanding of the relationship between venous reflux, clinical venous disease and the effects on quality of life (QoL) remains elusive. This study aimed to explore the impact of venous disease, and assess any incremental direct effect of progressive disease on health‐related QoL, with the ultimate aim to model venous morbidity.
Methods:
Consecutive patients with venous disease were assessed for inclusion in the study. Patients with isolated, unilateral, single superficial axial incompetence diagnosed on duplex imaging were included. Clinical grading was performed with the Clinical Etiologic Anatomic Pathophysiologic (CEAP) classification and Venous Clinical Severity Score (VCSS). Patients completed generic (Short Form 36, SF‐36®; EuroQol 5D, EQ‐5D™) and disease‐specific (Aberdeen Varicose Vein Questionnaire, AVVQ) QoL instruments. Multivariable regression modelling was performed, taking account of demographic and anatomical factors, to explore the effect of clinical severity on QoL impairment.
Results:
Some 456 patients with C2–6 venous disease were included, along with control data for 105 people with C0–1 disease. Increasing clinical grade corresponded strongly with deterioration in disease‐specific QoL (P < 0·001). This could be stratified into three distinguishable groups: C0–1, C2–4 and C5–6 (P < 0·001 to P = 0·006). Increasing clinical grade also corresponded with deterioration in the physical domains of SF‐36® (P < 0·001 to P = 0·016), along with EQ‐5D™ index utility (quality‐adjusted life year) scores (P < 0·001).
Conclusion:
Demonstrable morbidity was seen, even with uncomplicated venous disease. The physical impairment seen with venous ulceration was comparable with that seen in congestive cardiac failure and chronic lung disease. Copyright © 2011 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Deleterious effect |
| doi_str_mv | 10.1002/bjs.7500 |
| format | Article |
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A clear understanding of the relationship between venous reflux, clinical venous disease and the effects on quality of life (QoL) remains elusive. This study aimed to explore the impact of venous disease, and assess any incremental direct effect of progressive disease on health‐related QoL, with the ultimate aim to model venous morbidity.
Methods:
Consecutive patients with venous disease were assessed for inclusion in the study. Patients with isolated, unilateral, single superficial axial incompetence diagnosed on duplex imaging were included. Clinical grading was performed with the Clinical Etiologic Anatomic Pathophysiologic (CEAP) classification and Venous Clinical Severity Score (VCSS). Patients completed generic (Short Form 36, SF‐36®; EuroQol 5D, EQ‐5D™) and disease‐specific (Aberdeen Varicose Vein Questionnaire, AVVQ) QoL instruments. Multivariable regression modelling was performed, taking account of demographic and anatomical factors, to explore the effect of clinical severity on QoL impairment.
Results:
Some 456 patients with C2–6 venous disease were included, along with control data for 105 people with C0–1 disease. Increasing clinical grade corresponded strongly with deterioration in disease‐specific QoL (P < 0·001). This could be stratified into three distinguishable groups: C0–1, C2–4 and C5–6 (P < 0·001 to P = 0·006). Increasing clinical grade also corresponded with deterioration in the physical domains of SF‐36® (P < 0·001 to P = 0·016), along with EQ‐5D™ index utility (quality‐adjusted life year) scores (P < 0·001).
Conclusion:
Demonstrable morbidity was seen, even with uncomplicated venous disease. The physical impairment seen with venous ulceration was comparable with that seen in congestive cardiac failure and chronic lung disease. Copyright © 2011 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Deleterious effect</description><identifier>ISSN: 0007-1323</identifier><identifier>EISSN: 1365-2168</identifier><identifier>DOI: 10.1002/bjs.7500</identifier><identifier>PMID: 21604256</identifier><identifier>CODEN: BJSUAM</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Adult ; Aged ; Analysis of Variance ; Biological and medical sciences ; Case-Control Studies ; Disease Progression ; Female ; General aspects ; Health Status ; Humans ; Male ; Medical sciences ; Middle Aged ; Models, Biological ; Multivariate Analysis ; Quality of Life ; Surveys and Questionnaires ; Venous Insufficiency - psychology ; Young Adult</subject><ispartof>British journal of surgery, 2011-08, Vol.98 (8), p.1089-1098</ispartof><rights>Copyright © 2011 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3890-99f6e56c84f0fd900236478b251502398fc1a8c1ec20a0b1bf77ae25e1c5fbec3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbjs.7500$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbjs.7500$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24344062$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21604256$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carradice, D.</creatorcontrib><creatorcontrib>Mazari, F. A. K.</creatorcontrib><creatorcontrib>Samuel, N.</creatorcontrib><creatorcontrib>Allgar, V.</creatorcontrib><creatorcontrib>Hatfield, J.</creatorcontrib><creatorcontrib>Chetter, I. C.</creatorcontrib><title>Modelling the effect of venous disease on quality of life</title><title>British journal of surgery</title><addtitle>Br J Surg</addtitle><description>Background:
A clear understanding of the relationship between venous reflux, clinical venous disease and the effects on quality of life (QoL) remains elusive. This study aimed to explore the impact of venous disease, and assess any incremental direct effect of progressive disease on health‐related QoL, with the ultimate aim to model venous morbidity.
Methods:
Consecutive patients with venous disease were assessed for inclusion in the study. Patients with isolated, unilateral, single superficial axial incompetence diagnosed on duplex imaging were included. Clinical grading was performed with the Clinical Etiologic Anatomic Pathophysiologic (CEAP) classification and Venous Clinical Severity Score (VCSS). Patients completed generic (Short Form 36, SF‐36®; EuroQol 5D, EQ‐5D™) and disease‐specific (Aberdeen Varicose Vein Questionnaire, AVVQ) QoL instruments. Multivariable regression modelling was performed, taking account of demographic and anatomical factors, to explore the effect of clinical severity on QoL impairment.
Results:
Some 456 patients with C2–6 venous disease were included, along with control data for 105 people with C0–1 disease. Increasing clinical grade corresponded strongly with deterioration in disease‐specific QoL (P < 0·001). This could be stratified into three distinguishable groups: C0–1, C2–4 and C5–6 (P < 0·001 to P = 0·006). Increasing clinical grade also corresponded with deterioration in the physical domains of SF‐36® (P < 0·001 to P = 0·016), along with EQ‐5D™ index utility (quality‐adjusted life year) scores (P < 0·001).
Conclusion:
Demonstrable morbidity was seen, even with uncomplicated venous disease. The physical impairment seen with venous ulceration was comparable with that seen in congestive cardiac failure and chronic lung disease. Copyright © 2011 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Deleterious effect</description><subject>Adult</subject><subject>Aged</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Disease Progression</subject><subject>Female</subject><subject>General aspects</subject><subject>Health Status</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Models, Biological</subject><subject>Multivariate Analysis</subject><subject>Quality of Life</subject><subject>Surveys and Questionnaires</subject><subject>Venous Insufficiency - psychology</subject><subject>Young Adult</subject><issn>0007-1323</issn><issn>1365-2168</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0MlOwzAQBmALgaAUJJ4A5YI4BcZb7BwBsVUsEos4Wo47BkOalDgF-va4osBpLP2fRuOfkB0KBxSAHVav8UBJgBUyoLyQOaOFXiUDAFA55YxvkM0YXwEoB8nWyUbKQTBZDEh53Y6xrkPznPUvmKH36Pqs9dkHNu0sZuMQ0UbM2iZ7n9k69PNFWAePW2TN2zri9nIOyePZ6cPJRX51e355cnSVO65LyMvSFygLp4UHPy7TtbwQSldMUpnepfaOWu0oOgYWKlp5pSwyidRJX6HjQ7L_s3fate8zjL2ZhOjSzbbBdKHRSuhSCoAkd5dyVk1wbKZdmNhubn5_m8DeEtjobO0727gQ_53gQkDBkst_3Geocf6XUzCLtk1q2yzaNsej-8X89yH2-PXnbfdmCsWVNE835-ZO0Ytr8TAymn8DBpN-Ew</recordid><startdate>201108</startdate><enddate>201108</enddate><creator>Carradice, D.</creator><creator>Mazari, F. A. K.</creator><creator>Samuel, N.</creator><creator>Allgar, V.</creator><creator>Hatfield, J.</creator><creator>Chetter, I. C.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201108</creationdate><title>Modelling the effect of venous disease on quality of life</title><author>Carradice, D. ; Mazari, F. A. K. ; Samuel, N. ; Allgar, V. ; Hatfield, J. ; Chetter, I. C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3890-99f6e56c84f0fd900236478b251502398fc1a8c1ec20a0b1bf77ae25e1c5fbec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Disease Progression</topic><topic>Female</topic><topic>General aspects</topic><topic>Health Status</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Models, Biological</topic><topic>Multivariate Analysis</topic><topic>Quality of Life</topic><topic>Surveys and Questionnaires</topic><topic>Venous Insufficiency - psychology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carradice, D.</creatorcontrib><creatorcontrib>Mazari, F. A. K.</creatorcontrib><creatorcontrib>Samuel, N.</creatorcontrib><creatorcontrib>Allgar, V.</creatorcontrib><creatorcontrib>Hatfield, J.</creatorcontrib><creatorcontrib>Chetter, I. C.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carradice, D.</au><au>Mazari, F. A. K.</au><au>Samuel, N.</au><au>Allgar, V.</au><au>Hatfield, J.</au><au>Chetter, I. C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modelling the effect of venous disease on quality of life</atitle><jtitle>British journal of surgery</jtitle><addtitle>Br J Surg</addtitle><date>2011-08</date><risdate>2011</risdate><volume>98</volume><issue>8</issue><spage>1089</spage><epage>1098</epage><pages>1089-1098</pages><issn>0007-1323</issn><eissn>1365-2168</eissn><coden>BJSUAM</coden><abstract>Background:
A clear understanding of the relationship between venous reflux, clinical venous disease and the effects on quality of life (QoL) remains elusive. This study aimed to explore the impact of venous disease, and assess any incremental direct effect of progressive disease on health‐related QoL, with the ultimate aim to model venous morbidity.
Methods:
Consecutive patients with venous disease were assessed for inclusion in the study. Patients with isolated, unilateral, single superficial axial incompetence diagnosed on duplex imaging were included. Clinical grading was performed with the Clinical Etiologic Anatomic Pathophysiologic (CEAP) classification and Venous Clinical Severity Score (VCSS). Patients completed generic (Short Form 36, SF‐36®; EuroQol 5D, EQ‐5D™) and disease‐specific (Aberdeen Varicose Vein Questionnaire, AVVQ) QoL instruments. Multivariable regression modelling was performed, taking account of demographic and anatomical factors, to explore the effect of clinical severity on QoL impairment.
Results:
Some 456 patients with C2–6 venous disease were included, along with control data for 105 people with C0–1 disease. Increasing clinical grade corresponded strongly with deterioration in disease‐specific QoL (P < 0·001). This could be stratified into three distinguishable groups: C0–1, C2–4 and C5–6 (P < 0·001 to P = 0·006). Increasing clinical grade also corresponded with deterioration in the physical domains of SF‐36® (P < 0·001 to P = 0·016), along with EQ‐5D™ index utility (quality‐adjusted life year) scores (P < 0·001).
Conclusion:
Demonstrable morbidity was seen, even with uncomplicated venous disease. The physical impairment seen with venous ulceration was comparable with that seen in congestive cardiac failure and chronic lung disease. Copyright © 2011 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Adult Aged Analysis of Variance Biological and medical sciences Case-Control Studies Disease Progression Female General aspects Health Status Humans Male Medical sciences Middle Aged Models, Biological Multivariate Analysis Quality of Life Surveys and Questionnaires Venous Insufficiency - psychology Young Adult |
| title | Modelling the effect of venous disease on quality of life |
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