Lovastatin and valproic acid additively attenuate cell invasion in ACC-MESO-1 cells
► We examined the effects of lovastatin and valproic acid on a mesothelioma cell line. ► We found lovastatin and/or valproic acid did not reduce cell viability. ► We found lovastatin and/or valproic acid reduced cell invasion. ► We found the effect of lovastatin and valproic acid was additive when c...
Gespeichert in:
| Veröffentlicht in: | Biochemical and biophysical research communications 2011-07, Vol.410 (2), p.328-332 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 332 |
|---|---|
| container_issue | 2 |
| container_start_page | 328 |
| container_title | Biochemical and biophysical research communications |
| container_volume | 410 |
| creator | Yamauchi, Yoshikane Izumi, Yotaro Asakura, Keisuke Fukutomi, Toshinori Serizawa, Akihiko Kawai, Kenji Wakui, Masatoshi Suematsu, Makoto Nomori, Hiroaki |
| description | ► We examined the effects of lovastatin and valproic acid on a mesothelioma cell line. ► We found lovastatin and/or valproic acid did not reduce cell viability. ► We found lovastatin and/or valproic acid reduced cell invasion. ► We found the effect of lovastatin and valproic acid was additive when combined. ► Induction of autophagic changes was at least in part involved in this process.
Malignant pleural mesothelioma is known to be widely resistant to therapy and new treatment strategies are needed. Both statins and valproic acid are known to suppress the growth of multiple cancer lines, but the effects on mesothelioma cells are not well defined. In the present study we examined the effects of lovastatin and valproic acid on ACC-MESO-1, which is a human derived mesothelioma cell line. We found that lovastatin (2μM) and/or valproic acid (5mM) did not reduce cell viability nor induce apoptosis, but reduced cell invasion. The effect was additive when combined. Furthermore it was speculated that induction of autophagic changes was at least in part involved in this process. |
| doi_str_mv | 10.1016/j.bbrc.2011.05.149 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_874894081</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0006291X11009338</els_id><sourcerecordid>874894081</sourcerecordid><originalsourceid>FETCH-LOGICAL-c355t-77b75423832059c7fb960e6655ce7ba6d672075c946d216c9c20fc1708adf2fd3</originalsourceid><addsrcrecordid>eNp9kE9LwzAchoMobk6_gAfpzVPrL2mTNOBljPkHJjtMwVtIkxQyunY26WDf3sxNj54SyPO-vHkQusWQYcDsYZ1VVa8zAhhnQDNciDM0xiAgJRiKczQGAJYSgT9H6Mr7NUSwYOISjQhmnFCCx2i16HbKBxVcm6jWJDvVbPvO6URpZxJljAtuZ5t9okKw7aCCTbRtmsS1Mea6Nl6S6WyWvs1XyxT_vPlrdFGrxtub0zlBH0_z99lLulg-v86mi1TnlIaU84rTguRlToAKzetKMLCMUaotrxQzcSNwqkXBTByshSZQa8yhVKYmtckn6P7YGxd_DdYHuXH-sEC1thu8LHlRigJKHElyJHXfed_bWm57t1H9XmKQB5dyLQ8u5cGlBCqjyxi6O9UP1caav8ivvAg8HgEbP7lztpdeO9tqa1xvdZCmc__1fwMLI4Pf</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>874894081</pqid></control><display><type>article</type><title>Lovastatin and valproic acid additively attenuate cell invasion in ACC-MESO-1 cells</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Yamauchi, Yoshikane ; Izumi, Yotaro ; Asakura, Keisuke ; Fukutomi, Toshinori ; Serizawa, Akihiko ; Kawai, Kenji ; Wakui, Masatoshi ; Suematsu, Makoto ; Nomori, Hiroaki</creator><creatorcontrib>Yamauchi, Yoshikane ; Izumi, Yotaro ; Asakura, Keisuke ; Fukutomi, Toshinori ; Serizawa, Akihiko ; Kawai, Kenji ; Wakui, Masatoshi ; Suematsu, Makoto ; Nomori, Hiroaki</creatorcontrib><description>► We examined the effects of lovastatin and valproic acid on a mesothelioma cell line. ► We found lovastatin and/or valproic acid did not reduce cell viability. ► We found lovastatin and/or valproic acid reduced cell invasion. ► We found the effect of lovastatin and valproic acid was additive when combined. ► Induction of autophagic changes was at least in part involved in this process.
Malignant pleural mesothelioma is known to be widely resistant to therapy and new treatment strategies are needed. Both statins and valproic acid are known to suppress the growth of multiple cancer lines, but the effects on mesothelioma cells are not well defined. In the present study we examined the effects of lovastatin and valproic acid on ACC-MESO-1, which is a human derived mesothelioma cell line. We found that lovastatin (2μM) and/or valproic acid (5mM) did not reduce cell viability nor induce apoptosis, but reduced cell invasion. The effect was additive when combined. Furthermore it was speculated that induction of autophagic changes was at least in part involved in this process.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2011.05.149</identifier><identifier>PMID: 21672521</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Antineoplastic Combined Chemotherapy Protocols ; Autophagy ; Cell invasion ; Cell Line, Tumor ; Drug Synergism ; Humans ; Lovastatin ; Lovastatin - administration & dosage ; Mesothelioma ; Mesothelioma - drug therapy ; Mesothelioma - pathology ; Neoplasm Invasiveness ; Solitary Fibrous Tumor, Pleural - drug therapy ; Solitary Fibrous Tumor, Pleural - pathology ; Valproic acid ; Valproic Acid - administration & dosage</subject><ispartof>Biochemical and biophysical research communications, 2011-07, Vol.410 (2), p.328-332</ispartof><rights>2011 Elsevier Inc.</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c355t-77b75423832059c7fb960e6655ce7ba6d672075c946d216c9c20fc1708adf2fd3</citedby><cites>FETCH-LOGICAL-c355t-77b75423832059c7fb960e6655ce7ba6d672075c946d216c9c20fc1708adf2fd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bbrc.2011.05.149$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21672521$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamauchi, Yoshikane</creatorcontrib><creatorcontrib>Izumi, Yotaro</creatorcontrib><creatorcontrib>Asakura, Keisuke</creatorcontrib><creatorcontrib>Fukutomi, Toshinori</creatorcontrib><creatorcontrib>Serizawa, Akihiko</creatorcontrib><creatorcontrib>Kawai, Kenji</creatorcontrib><creatorcontrib>Wakui, Masatoshi</creatorcontrib><creatorcontrib>Suematsu, Makoto</creatorcontrib><creatorcontrib>Nomori, Hiroaki</creatorcontrib><title>Lovastatin and valproic acid additively attenuate cell invasion in ACC-MESO-1 cells</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>► We examined the effects of lovastatin and valproic acid on a mesothelioma cell line. ► We found lovastatin and/or valproic acid did not reduce cell viability. ► We found lovastatin and/or valproic acid reduced cell invasion. ► We found the effect of lovastatin and valproic acid was additive when combined. ► Induction of autophagic changes was at least in part involved in this process.
Malignant pleural mesothelioma is known to be widely resistant to therapy and new treatment strategies are needed. Both statins and valproic acid are known to suppress the growth of multiple cancer lines, but the effects on mesothelioma cells are not well defined. In the present study we examined the effects of lovastatin and valproic acid on ACC-MESO-1, which is a human derived mesothelioma cell line. We found that lovastatin (2μM) and/or valproic acid (5mM) did not reduce cell viability nor induce apoptosis, but reduced cell invasion. The effect was additive when combined. Furthermore it was speculated that induction of autophagic changes was at least in part involved in this process.</description><subject>Antineoplastic Combined Chemotherapy Protocols</subject><subject>Autophagy</subject><subject>Cell invasion</subject><subject>Cell Line, Tumor</subject><subject>Drug Synergism</subject><subject>Humans</subject><subject>Lovastatin</subject><subject>Lovastatin - administration & dosage</subject><subject>Mesothelioma</subject><subject>Mesothelioma - drug therapy</subject><subject>Mesothelioma - pathology</subject><subject>Neoplasm Invasiveness</subject><subject>Solitary Fibrous Tumor, Pleural - drug therapy</subject><subject>Solitary Fibrous Tumor, Pleural - pathology</subject><subject>Valproic acid</subject><subject>Valproic Acid - administration & dosage</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LwzAchoMobk6_gAfpzVPrL2mTNOBljPkHJjtMwVtIkxQyunY26WDf3sxNj54SyPO-vHkQusWQYcDsYZ1VVa8zAhhnQDNciDM0xiAgJRiKczQGAJYSgT9H6Mr7NUSwYOISjQhmnFCCx2i16HbKBxVcm6jWJDvVbPvO6URpZxJljAtuZ5t9okKw7aCCTbRtmsS1Mea6Nl6S6WyWvs1XyxT_vPlrdFGrxtub0zlBH0_z99lLulg-v86mi1TnlIaU84rTguRlToAKzetKMLCMUaotrxQzcSNwqkXBTByshSZQa8yhVKYmtckn6P7YGxd_DdYHuXH-sEC1thu8LHlRigJKHElyJHXfed_bWm57t1H9XmKQB5dyLQ8u5cGlBCqjyxi6O9UP1caav8ivvAg8HgEbP7lztpdeO9tqa1xvdZCmc__1fwMLI4Pf</recordid><startdate>20110701</startdate><enddate>20110701</enddate><creator>Yamauchi, Yoshikane</creator><creator>Izumi, Yotaro</creator><creator>Asakura, Keisuke</creator><creator>Fukutomi, Toshinori</creator><creator>Serizawa, Akihiko</creator><creator>Kawai, Kenji</creator><creator>Wakui, Masatoshi</creator><creator>Suematsu, Makoto</creator><creator>Nomori, Hiroaki</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110701</creationdate><title>Lovastatin and valproic acid additively attenuate cell invasion in ACC-MESO-1 cells</title><author>Yamauchi, Yoshikane ; Izumi, Yotaro ; Asakura, Keisuke ; Fukutomi, Toshinori ; Serizawa, Akihiko ; Kawai, Kenji ; Wakui, Masatoshi ; Suematsu, Makoto ; Nomori, Hiroaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c355t-77b75423832059c7fb960e6655ce7ba6d672075c946d216c9c20fc1708adf2fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Antineoplastic Combined Chemotherapy Protocols</topic><topic>Autophagy</topic><topic>Cell invasion</topic><topic>Cell Line, Tumor</topic><topic>Drug Synergism</topic><topic>Humans</topic><topic>Lovastatin</topic><topic>Lovastatin - administration & dosage</topic><topic>Mesothelioma</topic><topic>Mesothelioma - drug therapy</topic><topic>Mesothelioma - pathology</topic><topic>Neoplasm Invasiveness</topic><topic>Solitary Fibrous Tumor, Pleural - drug therapy</topic><topic>Solitary Fibrous Tumor, Pleural - pathology</topic><topic>Valproic acid</topic><topic>Valproic Acid - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamauchi, Yoshikane</creatorcontrib><creatorcontrib>Izumi, Yotaro</creatorcontrib><creatorcontrib>Asakura, Keisuke</creatorcontrib><creatorcontrib>Fukutomi, Toshinori</creatorcontrib><creatorcontrib>Serizawa, Akihiko</creatorcontrib><creatorcontrib>Kawai, Kenji</creatorcontrib><creatorcontrib>Wakui, Masatoshi</creatorcontrib><creatorcontrib>Suematsu, Makoto</creatorcontrib><creatorcontrib>Nomori, Hiroaki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamauchi, Yoshikane</au><au>Izumi, Yotaro</au><au>Asakura, Keisuke</au><au>Fukutomi, Toshinori</au><au>Serizawa, Akihiko</au><au>Kawai, Kenji</au><au>Wakui, Masatoshi</au><au>Suematsu, Makoto</au><au>Nomori, Hiroaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lovastatin and valproic acid additively attenuate cell invasion in ACC-MESO-1 cells</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2011-07-01</date><risdate>2011</risdate><volume>410</volume><issue>2</issue><spage>328</spage><epage>332</epage><pages>328-332</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>► We examined the effects of lovastatin and valproic acid on a mesothelioma cell line. ► We found lovastatin and/or valproic acid did not reduce cell viability. ► We found lovastatin and/or valproic acid reduced cell invasion. ► We found the effect of lovastatin and valproic acid was additive when combined. ► Induction of autophagic changes was at least in part involved in this process.
Malignant pleural mesothelioma is known to be widely resistant to therapy and new treatment strategies are needed. Both statins and valproic acid are known to suppress the growth of multiple cancer lines, but the effects on mesothelioma cells are not well defined. In the present study we examined the effects of lovastatin and valproic acid on ACC-MESO-1, which is a human derived mesothelioma cell line. We found that lovastatin (2μM) and/or valproic acid (5mM) did not reduce cell viability nor induce apoptosis, but reduced cell invasion. The effect was additive when combined. Furthermore it was speculated that induction of autophagic changes was at least in part involved in this process.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>21672521</pmid><doi>10.1016/j.bbrc.2011.05.149</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-291X |
| ispartof | Biochemical and biophysical research communications, 2011-07, Vol.410 (2), p.328-332 |
| issn | 0006-291X 1090-2104 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_874894081 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Antineoplastic Combined Chemotherapy Protocols Autophagy Cell invasion Cell Line, Tumor Drug Synergism Humans Lovastatin Lovastatin - administration & dosage Mesothelioma Mesothelioma - drug therapy Mesothelioma - pathology Neoplasm Invasiveness Solitary Fibrous Tumor, Pleural - drug therapy Solitary Fibrous Tumor, Pleural - pathology Valproic acid Valproic Acid - administration & dosage |
| title | Lovastatin and valproic acid additively attenuate cell invasion in ACC-MESO-1 cells |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T16%3A14%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Lovastatin%20and%20valproic%20acid%20additively%20attenuate%20cell%20invasion%20in%20ACC-MESO-1%20cells&rft.jtitle=Biochemical%20and%20biophysical%20research%20communications&rft.au=Yamauchi,%20Yoshikane&rft.date=2011-07-01&rft.volume=410&rft.issue=2&rft.spage=328&rft.epage=332&rft.pages=328-332&rft.issn=0006-291X&rft.eissn=1090-2104&rft_id=info:doi/10.1016/j.bbrc.2011.05.149&rft_dat=%3Cproquest_cross%3E874894081%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=874894081&rft_id=info:pmid/21672521&rft_els_id=S0006291X11009338&rfr_iscdi=true |