Functional evidence that Drosha overexpression in cervical squamous cell carcinoma affects cell phenotype and microRNA profiles

Although gain of chromosome 5p is one of the most frequent DNA copy‐number imbalances in cervical squamous cell carcinoma (SCC), the genes that drive its selection remain poorly understood. In a previous cross‐sectional clinical study, we showed that the microRNA processor Drosha (located on chromos...

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Veröffentlicht in:	The Journal of pathology 2011-08, Vol.224 (4), p.496-507
Hauptverfasser:	Muralidhar, Balaji, Winder, David, Murray, Matthew, Palmer, Roger, Barbosa-Morais, Nuno, Saini, Harpreet, Roberts, Ian, Pett, Mark, Coleman, Nicholas
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell migration Cell Movement - physiology Cervix chromosome 5 Cluster Analysis Data processing DNA Drosha Female Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic - genetics Humans Invasiveness microRNA MicroRNAs - genetics miRNA mRNA Mutation Neoplasm Invasiveness Neoplasm Proteins - deficiency Neoplasm Proteins - metabolism Northern blotting Oligonucleotide Array Sequence Analysis - methods Oncogenes Phenotype Reverse Transcriptase Polymerase Chain Reaction - methods Ribonuclease III - deficiency Ribonuclease III - metabolism RNA, Neoplasm - genetics RNA-mediated interference RNASEN squamous cell carcinoma Tumor Cells, Cultured Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - metabolism Uterine Cervical Neoplasms - pathology
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