Cytophagic Histiocytic Panniculitis after H1N1 Vaccination: A Case Report and Review of the Cutaneous Side Effects of Influenza Vaccines
Cytophagic histiocytic panniculitis (CHP) is a rare disease mostly caused by viral infections and/or lymphoproliferative diseases. We describe a case of CHP associated with H1N1 vaccine during the winter 2009–2010 vaccination campaign and discuss the cutaneous side effects of influenza vaccines. A 6...
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| Veröffentlicht in: | Dermatology (Basel) 2011-06, Vol.222 (3), p.217-220 |
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| creator | Pauwels, C. Bulai Livideanu, C. Maza, A. Lamant, L. Paul, C. |
| description | Cytophagic histiocytic panniculitis (CHP) is a rare disease mostly caused by viral infections and/or lymphoproliferative diseases. We describe a case of CHP associated with H1N1 vaccine during the winter 2009–2010 vaccination campaign and discuss the cutaneous side effects of influenza vaccines. A 6-year-old child presented with inflammatory subcutaneous nodules, which had appeared 1 month after the first injection of H1N1 vaccine and 1 week after the second injection. There was no history of recent infection. The skin lesions spontaneously disappeared without scarring. In CHP the abnormal cytokine secretion from neoplastic or reactive T cells promotes monocyte-macrophage activation and haemophagocytosis. Vaccination is not a common cause of CHP, but it seems possible that, as in infectious diseases, reactive T cells to the vaccine antigen could trigger CHP. |
| doi_str_mv | 10.1159/000326912 |
| format | Article |
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We describe a case of CHP associated with H1N1 vaccine during the winter 2009–2010 vaccination campaign and discuss the cutaneous side effects of influenza vaccines. A 6-year-old child presented with inflammatory subcutaneous nodules, which had appeared 1 month after the first injection of H1N1 vaccine and 1 week after the second injection. There was no history of recent infection. The skin lesions spontaneously disappeared without scarring. In CHP the abnormal cytokine secretion from neoplastic or reactive T cells promotes monocyte-macrophage activation and haemophagocytosis. Vaccination is not a common cause of CHP, but it seems possible that, as in infectious diseases, reactive T cells to the vaccine antigen could trigger CHP.</description><identifier>ISSN: 1018-8665</identifier><identifier>EISSN: 1421-9832</identifier><identifier>DOI: 10.1159/000326912</identifier><identifier>PMID: 21494027</identifier><language>eng</language><publisher>Basel, Switzerland: S. 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| subjects | Case and Review Case studies Child Granzymes - immunology Granzymes - metabolism Histiocytes - metabolism Histiocytes - pathology Histiocytosis - etiology Histiocytosis - metabolism Histiocytosis - pathology Humans Influenza Influenza A Virus, H1N1 Subtype - immunology Influenza Vaccines - adverse effects Influenza Vaccines - immunology Male Panniculitis - etiology Panniculitis - immunology Panniculitis - pathology Remission, Spontaneous Side effects T-Lymphocytes, Cytotoxic - metabolism T-Lymphocytes, Cytotoxic - pathology Vaccines |
| title | Cytophagic Histiocytic Panniculitis after H1N1 Vaccination: A Case Report and Review of the Cutaneous Side Effects of Influenza Vaccines |
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