The interaction between HLA shared epitope alleles and smoking and its contribution to autoimmunity against several citrullinated antigens

Objective Recent data suggest that a gene–environment interaction between smoking and the HLA shared epitope alleles plays a role in shaping the autoimmune reaction to specific citrullinated antigens. This study was undertaken to determine the effects of HLA shared epitope alleles and tobacco exposu...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2011-07, Vol.63 (7), p.1823-1832
Hauptverfasser:	Willemze, Annemiek, van der Woude, Diane, Ghidey, Wendimagegn, Levarht, E. W. Nivine, Stoeken‐Rijsbergen, Gerrie, Verduyn, Willem, de Vries, René R. P., Houwing‐Duistermaat, Jeanine J., Huizinga, Tom W. J., Trouw, Leendert A., Toes, René E. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Alleles Antibodies Antigens Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - immunology Autoantibodies - genetics Autoantibodies - immunology Autoimmunity - genetics Autoimmunity - immunology Biological and medical sciences Diseases of the osteoarticular system Enzyme-Linked Immunosorbent Assay Epitopes - genetics Epitopes - immunology Female Genetic Predisposition to Disease HLA Antigens - genetics HLA Antigens - immunology Humans Immune system Immunoglobulin M - genetics Immunoglobulin M - immunology Logistic Models Male Medical sciences Middle Aged Odds Ratio Risk Factors Smoking Smoking - genetics Smoking - immunology Tobacco Tobacco, tobacco smoking Toxicology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!